Pharmaceutical Cream

1. PHARMACEUTICAL CREAMS
ANUPRIYA SINGH
B.PHARM(Ay)-4th YEAR
BANARASA HINDU UNIVERSITY 1

2. context-
 What is cream.
 Anatomy of skin.
 Types of cream.
 Components of cream.
 Manufacturing of cream.
 Uses of cream.
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3. •WHAT IS CREAM????
 Cream consist of medicament dissolved or suspended
in water removable or emollient bases, classified as
water-in-oil or oil-in-water and intended for
application on the skin or accesible mucous membrane
to provide localized and sometimes systemic effects at
the site of application.
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4. ANATOMY OF SKIN
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5. TYPES OF CREAM.
On the basis of phase-
 OIL- IN-WATER ( O/W)-
As- Fluocinolone acetonide cream
• WATER-IN-OIL (W/O)-
As- cold cream
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6. CLEANISING CREAMS-
 Keeping the body clean is the most important and
primitive need to on account of personal hygiene and
beautification which leads to the need of cosmetics.
 USES-
 Cleanishing cream is required for removal of facial
make up, surface grime,oil.
 DESIRABLE PROPERTIES OF CLEANISING CREAM-
 It should be shoften on application to the skin.
 It should spread easily without draging.
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7. TYPES OF CLEANISING CREAM-
 White ,emuslsified cold cream (Bee wax-borax type)-
 These are white, of high lusture,and free from
graininess.
 These are o/w type of emulsion.
 The cream have firm consistency.
 They liquefy on application to the skin and spread
with ease.
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8. .
 Liquefying cleansing creams-
 These are translucent liquefying anhydrous type of
cleanising cream.
 They have a mixture of oil and waxes and have such
consistency that they liquefy when gently massaged on
the skin.
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9. VANISHING AND FOUNDATION CREAMS
 Vanishing creams- Creams which spread easily and
seem to disappear rapidly when rubbed are termed as
vanishing cream.
 The basic ingredients are - 65%-75% water ,15%-20%
stearic acid ,8-12% glycerol, 0.5-15% alkali
(KOH),preservative and perfume.
 Foundation creams-
 Creams which provide base makeup to hold the
powder or other make up above it.
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10. NIGHT AND MASSAGE CREAMS-
 Creams which are generally applied on skin and left for
few and several hours mostly overnight, known as
night cream.
 Creams which act by providing emollient action by
rubbing ,called as massage cream.
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11. HAND AND BODY CREAMS-
 Hand and other body parts skin may be exposed to
water, water soap, detergents causes removal of lipids
and others secretions from the skin.
 Skin dry, scaly , infections due to microbes can leads to
dermatitis, so to control all these hand body creams
are applied.
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12. .
 Main function of hand and body creams are-
 Provide an oily film to protect the skin.
 Keep the skin smooth but not greasy.
 Easy to apply.
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13. ALL PURPOSE CREAMS-
 They act nourishing or night cream when applied
excessively, they function as hand creams when
applied sparingly, thus they are called All purpose
cream.
 These were also known as sports cream, as they were
used by sportsman in skiing and outdoor activities.
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14. THE COMPOSITION OF THESE CREAM IS SUCH
THAT IT CAN ACT-
 As a foundation cream to provide a foundation base for
make up.
 As a Cleanishing cream and liquefy easily.
 As a hand cream and should have emollient
characters.
 As a protective cream and should form a non occlusive
film.
 As a cream to smooth the rough surface of the skin.
 So, therefore called All purpose cream.
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15. CLASSIFICATION OF CREAM ON THE BASIS
OF FUNCTION-
 Cleansing and cold cream.
 Foundation and vanishing cream.
 Night and massage cream.
 Head and body cream.
 All purpose and general cream.
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16. FORMULATIONS COMPONANTS-
 ANTIOXIDANT- ex.-TBHT, Ascorbic acid.
 BASE- ex. White petrolium, Lanolin, cholesterol.
 BUFFER- ex. Citrate buffer ,phosphate buffer.
 CHELATING AGENTS- ex. EDTA , Citric acid.
 EMULSIFYING AGENT- ex. Detergent ,Cetostearyl
alchohol.
 HUMECTANT- ex. Glycerin,propylene glycol, PEG.
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17. .
 PERMEATION ENHANCER- ex. Ethanol , oleic acid,
PEG
 PRESERVATIVE – ex. Benzoic acid,phenyl ethyl
alchol.
 THICKENING AGENT- ex. Cellolose, pectin
,carbopol.
 FRAGRANCES- ex. Lavender oil,rose oil, lemon oil.
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18. CLASSIFICATION OF BASE-
 Hydrocarbon base.
 Absorption base.
 Emulsion base.
 Water soluble base.
 Water removable base.
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19. MANUFACTURING PROCESS-
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20. TRITURATION METHOD-
 TRITURATION METHOD :
 Used for finely divided insoluble powder particles or
liquids.
 Insoluble powders are added by geometric dilution.
 Liquids are added by making well in centre.
 Air pocket formation avoided.
 Mortar and pestle used when we have large quantities.
 Involved use of glass slab when small quantities are
used.
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21. LEVIGATION-
 Incorporation of insoluble coarse particles.
 Insoluble coarse powder is rubbed with molten base or
liquid or semisolid base.
 Also knows as Wet grinding.
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22. FUSION METHOD-
• The fusion method is followed when the drugs and
other solid are soluble in the ointment bases.
• The base is liquefied and the soluble components are
dissolved in the molten base.
 The congeal mixture is then speculated or triturated to
obtain a smooth texture.
 Care is taken to avoid thermal degradation of the base
or other components during the fusion process.
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23. MECHANICAL ADDITION-
 Water- removable creams are basically hydrophilic
type emulsions.
 A hydrophilic emulsifying agent is included in the
aqueous phase in order to obtain stable oil-in-water
dispersion.
 Sodium lauryl sulfate is used in the preparation of
hydrophilic ointment.
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24. MACHINES-
 A wide range of machines are available are for the large
scale production of creams.
 Creams are produced with the help of low-shear and
high emulsifiers.
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26. Ayurvedic fairness cream-
 FAIRNESS CREAM-
KEY INGREDIENTS
 Persian rose.
 Walnut.
 Aloe vera.
 Mandarin orange.
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27. USES OF CREAMS:
• Cleanising creams is a facial care product that is use to
remove dead skin cells ,oil , dirt, and other types of
pollutants from the skin of the face.
• Vanishing creams are used in hot climates which cause
perspiration on the face.
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28. .
 The provision of a barrier to protect the skin.
 To aid in the retention of moisture (especially water –
in –oil ).
 Creams can be used for administering drugs via the
vaginal route (e.g. Triple sulfa vaginal creams ).
 Creams are used to help sun burn.
 Emollient effects.
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29. NOVEL ADVANCES AND RECENT
DEVELOPMENT
 CREAMS CONTAINING MICROSPHERES:
 Albumin microsphere containing vitamin A can be
administered by using creams 222 +_25 micrometer
size of microsphere of vitamin A were produced by
emulsion method.
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30. .
 LAMELLAR FACED CREAMS:
 They are liquid parafin in water emulsion prepared
from certified/fatty alcohol.
 CREAMS CONTAINING LIPID NANOPARTICLES:
 The develpoment of a water-in oil cream containing
small particles of solid paraffin was studied.
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