Renowned hair restoration physician and Top Hair Transplant Surgeon, Dr. Alan J Bauman MD ABHRS from Boca Raton, FL was invited to share his knowledge with the attendees at the 9th Annual Biohacking Conference in Orlando, FL in June 2023. The largest biohacking conference in history, the event was spearheaded by the father of biohacking, Dave Asprey. When Dave chose to biohack his hair, he turned to none other than Dr. Alan Bauman, hair transplant surgeon and fellow biohacker. Listen to the latest technology for Biohacking Baldness on Dave Asprey's The Human Upgrade, episode 727. Learn the latest in photobiomodulation, pharmaceuticals, photoceuticals, photobiomodulation, growth factors, peptides, TED, PRP, stem cell derived Exosome Therapy, FUE hair transplantation and much more in this presentation. Contact Dr. Alan Bauman at baumanmedical.com/schedule-consultation to book a private consultation from your home or phone to help extend your HAIRSPAN.

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B I O H A C K I N G
B A L D N E S S
A HAIRSPAN TO MATCH YOUR HEALTHSPAN!
ALAN J. BAUMAN, MD, ABHRS

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Certifications, Affiliations & Honors
• Diplomate, American Board of Hair Restoration Surgery
• Fellow, International Society of Hair Restoration Surgery
• Accepted, International Alliance of Hair Restoration Surgeons
• Recommended, American Hair Loss Association
• 6x “#1 Top Hair Restoration Surgeon in America” - Aesthetic
Everything™
• One of the “Ten CEOs Transforming Healthcare in America” - Forbes
• “Top Hair Transplant Surgeons in the World Today” - Ape To Gentleman
Experience Since 1997
• over 33,000 hair loss patients treated
• over 12,000 hair transplant procedures performed
• over 11,000 Regenerative and PRP hair regrowth treatments
• baumanmedical.com/about-us
• @DrAlanBauman
ALAN J. BAUMAN, MD, ABHRS, FISHRS

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Hair Transplantation,
Regenerative Medicine (PRP) for Hair Regrowth
Trichology:
Hair & Scalp Health
Hair Loss
Management
Education & Training
Research & Consulting
Hair & Scalp
Prosthetics
“TheHairHospital”

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Hair Transplantation,
Regenerative Medicine (PRP) for Hair Regrowth
Trichology:
Hair & Scalp Health
Hair Loss
Management
Education & Training
Research & Consulting Hair & Scalp
Prosthetics
“TheHairHospital”

5. Goals & Objectives
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
• Hair & Self-Image
• Physiology of the Hair Follicle
• Pathophysiology of Hair Loss
• New Biohacking Stratagems for Hair Loss
• Dave Asprey’s Hair UPGRADE!
• LIVE: NEW Technology Demo!

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
BEFORE AFTER
Dave’s Hair Upgrade!

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
! AI Evaluation / Tracking / Measuring
" Genomics & Genetics
# Personalized Precision Medicine
$ Peptides & Pharmaceuticals
% Non-Chemical Therapies
⚡ Photobiomodulation
' Nutrition/Nutraceuticals
( Regenerative Medicine / Stem Cell Therapy
) Lifestyle Factors
⏰ (NEW!) Circadian / Biologic Clock Therapy
[“There’s an app for that,” Stay tuned!!!]
Biohack Your Hair!
Ep 727: Biohacking Baldness
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daveasprey.com/dr-bauman-727

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
H
A
I
R
Beauty
andYouth
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BIOHACKING BALDNESS - ALAN J BAUMAN MD

9. • Fear/anxiety ~ Sickness or Illness
• Low Self-Esteem/Self-Confidence
• Feel Older / Less Attractive
• Camouflage/Compensate
• Avoid Social Situations
• Panic - Internet Search
• Doctor Shopping
• Miracle Cures
HairLOSS
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BIOHACKING BALDNESS - ALAN J BAUMAN MD

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Hair & Skin
Anatomy
The Pilosebaceous Unit:

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
The Pilosebaceous Unit:
• arteries/veins/nerves
• sebaceous & apocrine glands
• smooth muscle
• stem cell niche
• endocrine/paracrine
• adipose
• fibroblasts
• local chronobiologic clock
Hair & Skin
Anatomy

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
The Pilosebaceous Unit:
• arteries/veins/nerves
• sebaceous & apocrine glands
• smooth muscle
• stem cell niche
• endocrine/paracrine
• adipose
• fibroblasts
• local chronobiologic clock
Hair & Skin
Anatomy

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
100,000-150,000 - scalp
~84% growing phase
~1cm (1/4-1/2 inch) per month
~50,000 inches / month total
~1667 inches / day total
~138 ft of Hair Per Day
~6ft of Hair Per Hour
“A highly accessible dermal appendage which is a musculo-neuro-vascular-endocrine mini-organ
containing a stem cell niche capable of degeneration and regeneration that en masse can elicit a
significant emotional response in the owner or observer!” -Dr. Alan Bauman
Maksim Plikus
Hair & Skin
Anatomy

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
100,000-150,000 - scalp
~84% growing phase
~1cm (1/4-1/2 inch) per month
~50,000 inches / month total
~1667 inches / day total
~138 ft of Hair Per Day
~6ft of Hair Per Hour
“A highly accessible dermal appendage which is a musculo-neuro-vascular-endocrine mini-organ
containing a stem cell niche capable of degeneration and regeneration that en masse can elicit a
significant emotional response in the owner or observer!” -Dr. Alan Bauman
Maksim Plikus
Hair & Skin
Anatomy

15. Hair Follicle Cycle Timing:
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Anagen
Catagen
Telogen
Healthy Follicle

16. Human Hair Follicle Stem Cells & Cycling
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Cotsarelis G. Gene expression profiling gets to the root of human hair follicle stem cells. J Clin Invest. 2006;116(1):19–22. doi:10.1172/JCI27490
DERMAL PAPILLA
(Proliferating
Progenitor Cells)
BULGE
(Stem Cells)
Dermal Papilla

17. Hair Follicle Stem Cell Signaling
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Ya-Chieh Hsu & Elaine Fuchs; A family business: stem cell progeny join the niche to regulate homeostasis, Nature Reviews Molecular Cell Biology 13, 103-114 (February 2012) doi:10.1038/nrm3272
Hair Follicle
Stem Cell Niche:
Bulge
Dermal Papilla
Dermal Fibroblasts
Adipocytes

18. Hair Signal Hyperactivates Follicles [in mice]
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Liu Y, et al. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state. Dev Cell. 2022 Jul 25;57(14):1758-1775.e7.
Maksim V. Plikus

19. Multifactorial Pathophysiology of Alopecia (Hair Loss)
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
EXTRINSIC
UV, Heat, Toxins,
Chemicals, Styling,
Mechanical Forces
Sadick
N
et
al
(2017).
J
Drugs
and
Dermatol
11:135-140
SCALP HEALTH
+
OVERALL HEALTH
↓
HAIR GROWTH
INTRINSIC
Genetics
Inflammation
Hormones
Illness/Fever
Stress/Cortisol
Nutritional Deficiencies
Mitochondrial Dysfunction
Stem Cell Escape
Senescence

20. Hair Follicle Disregulation
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
MINIA
TURIZING
shorter
thinner
weaker
wispier
depigmented
Genetics
Meds / Vaccines
Illness / COVID
Nutrition
Stress
Hormones
Inflammation
etc.
DECREASED ANAGEN
PROLONGED CATAGEN/TELOGEN

21. Diagnosis & Evaluation
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BIOHACKING BALDNESS - ALAN J BAUMAN MD

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Personalized Precision Medicine:
Genetic “TrichoTest” Analysis
PATHWAYS OF HAIR LOSS AND TREATMENT:
Prostaglandin Metabolism
Inflammation/Immune Response
Androgen Metabolism
Vitamin Metabolism
Insulin Metabolism
Cardiovascular/Circulatory System
Collagen Synthesis
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BIOHACKING BALDNESS - ALAN J BAUMAN MD

23. BIOHACKING…? ➡ MEASURE IT!
Evaluation: Hair Mass Index (HMI], Global Photos, Trichoscopy
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Wikramanayake TC, Mauro LM, Tabas IA, Chen AL, Llanes IC, Jimenez JJ. Cross-section Trichometry: A Clinical Tool for Assessing the Progression and Treatment Response of Alopecia. Int J Trichology. 2012;4(4):259–264.

24. AI Measurements & Tracking
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
• hair count per cm
• sum of hair width per cm
• terminal to vellus ratio
• ave. hairs per follicular unit
• ave hair width
• mean inter-follicular distance
Visit
BOOTH
#710!

25. Key Steps: Treatment Stratagems
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BIOHACKING BALDNESS - ALAN J BAUMAN MD

26. Treatment Stratagems
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
⬇Triggers & Risk Factors
Genetic Testing, Biomarkers, Medical Conditions, Meds, Lifestyle, Stress,
Scalp Health, Circuluation, Hormone Optimization, Styling/Hair Care
⬇Androgen Effects in ♂ & Androgen-Sensitive ♀
Pharmaceutical, Nutraceutical
⬆Hair Follicle Function
Pharmaceutical, Nutraceutical, Phototherapy (Laser Therapy),
Regenerative Medicine (PRP, PDOgro, Growth Factors/Exosomes, TED)
Redistribute Permanent Follicles into Depleted Areas
Minimally-Invasive Hair Transplantation
FUE Follicular Unit Extraction - No Linear Scar
Areas of Research / Future Therapy
Hair Multiplication (“cloning”), Genetic Modification (DNA editing), Hair
Stem Cell Banking

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
• Photobiomodulation / Low Level Laser Therapy – increases mitochondrial membrane potential, ↑ATP
• Nutritional Modification – supplements like Biotin, Collagen, Nutraceuticals, Herbs, Nitric Oxide
• Finasteride, Dutasteride – inhibits dihydrotestosterone DHT production
• Minoxidil – potassium channel opener, vasodilator, promote/prolong anagen
• Microneedling – promote/prolong anagen, collagen production, new blood vessel formation
• TED Trans-Epidermal Delivery of Peptides / Growth Factors – GHK-Cu, Thymosin β-4/Prohairin β-4, FGF, VEGF, etc.
• Platelet Rich Plasma – injectable autologous growth factors, anti-inflammatories
• ”Stem Cell Therapy” – exosomes, growth factors, conditioned media
• PDOgro™ - synthetic, absorbable PDO polydioxanone “threads”
• FUE Hair Transplantation – redistribution of DHT-resistant follicles from the back of the scalp to the severely
depleted area leaving NO LINEAR SCAR
Treatment Stratagems
LaserCa
PRP
Minoxidil Hair Transplant
LaserCap PDO

28. NEW: TURBO LaserCap
• only 5min/day
• 25% more coverage
• Packs flat
• Powerful (>300 diodes)
• FDA-cleared Hair Growth
• Zero side-effects
PHOTOBIOMODULATION:
Low Level Laser Therapy Hair Regrowth
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
@DrAlanBauman
@DrAlanBauman
@DrAlanBauman
@DrAlanBauman
BEFORE 12-MOS
BEFORE 12-MOS
Darwin E, Heyes A, Hirt PA, Wikramanayake TC, Jimenez JJ. Low-level laser therapy for the treatment of androgenic alopecia: a review. Lasers Med Sci. 2018 Feb;33(2):425-434. doi: 10.1007/s10103-017-2385-5. Epub 2017 Dec 21. PMID: 29270707.
Avram MR, Leonard RT Jr, Epstein ES, Williams JL, Bauman AJ. The current role of laser/light sources in the treatment of male and female pattern hair loss. J Cosmet Laser Ther. 2007 Mar;9(1):27-8. doi: 10.1080/14764170601134479. PMID: 17457763.
Gupta AK, Foley KA. A Critical Assessment of the Evidence for Low- Level Laser Therapy in the Treatment of Hair Loss. Dermatol Surg. 2017;43(2):188-197. doi: 10.1097/DSS.0000000000000904
“The best on the market.”
- Robb Report

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Price et al. Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment. J Am Acad Dermatol 1999;41:717-21
Vastarella M, Cantelli M, Patrì A, Annunziata MC, Nappa P, Fabbrocini G. Efficacy and safety of oral minoxidil in female androgenetic alopecia. Dermatol Ther. 2020 Nov;33(6):e14234. doi: 10.1111/dth.14234. Epub 2020 Sep 14.
Female
Male
ORAL
Microdose
Minoxidil
[~0.6mg-6mg/day]

30. @DrAlanBauman
@DrAlanBauman
@DrAlanBauman
@DrAlanBauman
Compounded Topical “Formula 82M” Minoxidil
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Price et al. Changes in hair weight and hair count in men with androgenetic alopecia, after application of 5% and 2% topical minoxidil, placebo, or no treatment. J Am Acad Dermatol 1999;41:717-21
Sharma A, et. al. Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes. Dermatol Ther. 2019 May;32(3):e12915.
@DrAlanBauman
@DrAlanBauman
@DrAlanBauman
@DrAlanBauman
• Less Greasy
• Dries Quickly
• Penetration
• Powerful
• Converts Non-responders
BEFORE
BEFORE
BEFORE
BEFORE 6MOS
6MOS
6MOS
6MOS
Minoxidil 5% - emulsification
Tretinoin 0.01% - ⬆penetration, ⬆SULT1A1
Fluocinolone 0.01% - anti-inflammatory
Oleanolic Acid - mild anti-androgen
Algae Extract - antioxidant
Phytantriol - conditioner for hair/skin
*NO Propylene Glycol*
Non-Greasy / No Residue

31. @DrAlanBauman
Multi-Therapy
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Arlene 68F: 82M Minox + Laser Therapy + Nutritionals
Laura 70F: 82M Minox + Laser Therapy + Nutritionals
Cynthia 65F: 82M Minox + Laser Therapy
@DrAlanBauman @DrAlanBauman
@DrAlanBauman @DrAlanBauman @DrAlanBauman
@DrAlanBauman @DrAlanBauman
@DrAlanBauman
@DrAlanBauman
BEFORE 12-MOS
BEFORE 12-MOS
6-MOS
BEFORE 3-MOS

32. Nutrition & Nutraceuticals
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
PROTEIN / COLLAGEN
IRON
MULTI-VITAMIN: BAUMANMD “A-LIST”
BIOTIN: BAUMANMD “HERO” 10,000 mcg/day
BaumanMD Wellness System for Hair
Nitric Oxide Supplementation
HERBS & NUTRACEUTICALS
Ashwagandha: Anti-stress (Cortisol, ↓CRP), “ZENMASTER”
Curcumin: Anti-inflammatory
Saw Palmetto: Anti-androgen
Probiotics
Microbiome/Gut-Skin Axis: inflammation/nutrient absorption
Ablon G, Kogan S. A Six-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of a Nutraceutical Supplement for Promoting Hair Growth in Women With Self-Perceived Thinning Hair. J Drugs Dermatol. 2018 May 1;17(5):558-565.
Ablon G. A 6-month, randomized, double-blind, placebo-controlled study evaluating the ability of a marine complex supplement to promote hair growth in men with thinning hair. J Cosmet Dermatol. 2016 Dec;15(4):358-366.

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
PRP: PLATELET-RICH PLASMA
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
BIOHACKING BALDNESS - ALAN J BAUMAN MD
biohacking
CONGRESS
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BIOHACKING BALDNESS - ALAN J BAUMAN MD

34. PRP
| MEDICAL MANAGEMENT OF HAIR LOSS FOR THE ANTIAGING PRACTICE | ALAN J BAUMAN MD
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35. Platelet Concentration. vs. Stem Cell Activity
& New Blood Vessel Formation
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
There is direct relationship between
platelet concentration
and MSC migration and proliferation
Haynesworth
et
al,
2002
Haynesworth et al, 2002 48th Annual Meeting of the Orthopedic Research Society
Giusti I, Rughetti A, D’Ascenzo S, et al. Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion. 2009;49:771–8.
Optimal: ~1.5M platelets/µL
1.5
What’s In
YOUR PRP?
10-12 Billion platelets

36. PRP in Male
Androgenetic Alopecia
Dual Spin: 1.5M Platelets/µl
[>11 Billion Platelets]
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
BEFORE PRP AFTER 9 MOS
AFTER 9 MOS
AFTER 9 MOS
BEFORE PRP
BEFORE PRP
@DrAlanBauman @DrAlanBauman @DrAlanBauman @DrAlanBauman
@DrAlanBauman
@DrAlanBauman

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
BEFORE PRP AFTER 12 MOS
BEFORE PRP AFTER 12 MOS
BEFORE PRP AFTER 12 MOS
@DrAlanBauman
@DrAlanBauman
@DrAlanBauman @DrAlanBauman
@DrAlanBauman
@DrAlanBauman
PRP in Female Androgenetic Alopecia
Dual Spin: 1.5M platelets/µl
[>11 Billion Platelets]

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
PRP in Female Traction Alopecia
Dual Spin: 1.5M platelets/µl. [>11 Billion Platelets]
BEFORE BAUMAN-PRP™
@
D
RA
LA
N
BA
U
M
A
N
@
D
RA
LA
N
BA
U
M
A
N
4 MOS AFTER BAUMAN-PRP™
TRACTION ALOPECIA IN AFRICAN AMERICAN FEMALE
BEFORE BAUMAN-PRP™

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
E X O S O M E S

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BIOHACKING BALDNESS - ALAN J BAUMAN MD
• Exosomes = extracellular vesicles or “packets”
30-100nm
• Cell-to-Cell paracrine communication
• Protiens, Lipids, mRNAs, miRNA, metabolites
• EVs - tissue regeneration, immune
modulation, promote angiogenesis,
biomarkers of disease & aging
Stem Cell-Derived EXOSOMES
Courtesy: Kimera Exosomes

41. Exosomes & Hair Growth
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
(Dr. Dan McGrath - TX)
Before 90 Days
(Dr. Dan McGrath - TX)
One Month
Before
Bone Marrow-MSC-Exosomes

42. HAIR
TRANSPLANT
SURGERY
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43. Hair Transplant Surgery
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44. Donor Healing From “FUE” Harvesting
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45. Results from “FUE” Transplantation
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@DRALANBAUMAN
AFTER FUE HAIR TRANSPLANT BY DR. BAUMAN
BEFORE
@DRALANBAUMAN
@DRALANBAUMAN
AFTER FUE HAIR TRANSPLANT BY DR. BAUMAN
BEFORE
@DRALANBAUMAN

46. Follicular Unit Extraction
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Courtesy: Alan J. Bauman, M.D.

47. ©
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BIOHACKING BALDNESS - ALAN J BAUMAN MD

48. Before, 6 Mos, 12 Mos…
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49. Female Hair
Transplantation
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BEFORE 24 HRS 12 MOS
BEFORE 12 MOS

50. ©
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Courtesy: Alan J. Bauman, M.D.
Patient: Lawrence Bauman (Dr. Bauman’s Father)
Hair Transplantation: Before/After

51. ©
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Dave Asprey’s UPGRADED Hair:
BEFORE PLANNING 12MOS
24HRS

52. ©
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Dave Asprey’s UPGRADED Hair:
BEFORE PLANNING 12MOS
FUE Hair Transplant Procedure:
4087 total grafts for hairline, temples,
temple points and vertex/crown area.
24HRS

53. ©
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Dave Asprey’s UPGRADED Hair:
Dave Asprey Hair Transplant VIDEO

54. TED: TransEpidermal Delivery
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NEW!!

55. TED: TransEpidermal Delivery
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>> LIVE DEMO at Booth #710 <<

56. TED: TransEpidermal Delivery
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
Cu-GHK, VEGF, Tβ4-derivative, Amino Acids,
Exfoliants, Antioxidants & More!
>> LIVE DEMO at Booth #710<<

57. TED: TransEpidermal Delivery
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>> LIVE DEMO at Booth #710 <<

58. TED: TransEpidermal Delivery
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BIOHACKING BALDNESS - ALAN J BAUMAN MD
>> LIVE DEMO at Bauman Medical Booth #710 <<

59. NEW: Circadian Rhythm, Clock Genes & Hair Growth
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In vivo - circadian genes
are expressed in the hair
follicle
Ex vivo - circadian clock
regulates the human hair
cycles silencing BMALI,
CLOCK, PER1 extends
anagen; controls
pigmentation
melanocytes

60. What is Circadian Therapy?
How Can It Help Hair Growth?
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DOWNLOAD THE APP —> baumanmedical.com/haircoach-app
Reminder: Trigger
Routine: Consistency
Reward: Gamify/Celebrate Results
# Goals: Specific & Achievable
Leverage our natural Sleep-Wake Cycle for
Health and Habit Formation
THE 3 RS OF HABIT FORMATION
Or Visit:
https://baumanmedical.com/haircoach-app
30-DAY FREE TRIAL!
GROW30

61. Circadian Hair Growth Therapy?
“There’s An App For That!”
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DOWNLOAD THE APP —> baumanmedical.com/haircoach-app
Reminder: Trigger
Routine: Consistency
Reward: Gamify/Celebrate Results
Dr. Alan Bauman &
Dr. Daniel Gartenberg
Bauman Medical X SleepSpace
THE 3 RS OF HABIT FORMATION
Or Visit:
https://baumanmedical.com/haircoach-app
30-DAY FREE TRIAL!
GROW30

62. Stem Cells &
Hair Growth:
The FUTURE…?
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63. Functional Hair Follicle Regeneration
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Ji, S., Zhu, Z., Sun, X. et al. Functional hair follicle regeneration: an updated review. Sig Transduct Target Ther 6, 66 (2021).
Lee, J., Rabbani, C.C., Gao, H. et al. Hair-bearing human skin generated entirely from pluripotent stem cells. Nature 582, 399–404 (2020).
3D Culture Lab-Grown Hair Follicle Organoids
Jiyoon
Lee,
Karl
R.
Koehler

64. Stem Cells & Hair Growth: The FUTURE…?
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Japan: Human hair follicles derived from
stem cells transplanted onto a ‘nude’ mouse.
San Diego, CA: Researchers at Stemson
create new hair follicles using iPSCs.
Alexey
Terskikh

65. Thank You!
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@DrAlanBauman
BaumanMedical.com
SCAN TO
ASK ME
ANY
QUESTION!