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© 2016 Advanced Maternity Innovations, LP - All Rights Reserved
American Medical Technologies, Improving
Pregnancy Management
This presentation and the related materials include “forward-looking
statements”. The opinions, forecasts, projections, or other statements
(“statements”) other than statements of historical fact, are forward-looking
statements. Although Reproductive Research Technologies, LP (“RRT”) believes
that the expectations reflected in such forward-looking statements are reasonable,
it is highly likely that actual results and timing will vary, and may vary
substantially, from plans and projections shown. Many of the factors which will
determine actual results are not within the control of RRT. A high degree of risk
and uncertainty is inherent in the development of the RRT business, technology
systems and other product applications.
An investment in RRT is subject to substantial risks. No person should invest in
RRT who is not in a position to hold the investment indefinitely or sustain the loss
of his/her entire investment. Please review this information carefully and request
from RRT any additional information deemed to be necessary to fully evaluate
the risks and the merits of an investment in RRT. Many of the factors which will
determine actual results are not within the control of the general partner. This
investment is suitable only for persons who have substantial financial resources.
No liquidity event may occur and there may not be distributions.
IMPORTANT NOTICE
ADVANCED MATERNITY INNOVATIONS, LP
American Medical Technologies, Improving Pregnancy Management
AS AN AMERICAN MEDICAL DEVICE TECHNOLOGY INNOVATOR AND DEVELOPER, WE INTEND TO LEAD THE WORLDWIDE
TECHNOLOGY REVOLUTION TO SIGNIFICANTLY IMPROVE THE QUALITY OF MATERNITY CARE AND THE DELIVERY OF NEW
BORN BABIES, RESULTING IN COST EFFECTIVE NEW AND ELEVATED STANDARDS OF CARE IN PREGNANCY MANAGEMENT.
VISION
OUR ULTIMATE GOAL IS ASSISTING CLINICIANS AND EXPECTANT MOTHERS, THROUGH ADVANCED AND INNOVATIVE
TECHNOLOGY, IN THE DELIVERY OF HEALTHY, HAPPY BABIES BY HEALTHY, HAPPY MOTHERS
DELIVERING A WIN FOR ALL
WE INTEND TO LEAD IN THE FIGHT TO REDUCE PRETERM BIRTH, RESULTING IN A POSITIVE IMPACT ON PATIENTS,
PROVIDERS, PAYORS, OUR PARTNERS, AND SOCIETY AT LARGE.
ADVANCED MATERNITY INNOVATIONS, LP
American Medical Technologies, Improving Pregnancy Management
WE WILL LEAD THE MATERNITY CARE REVOLUTION BY IMPROVING PREGNANCY MANAGEMENT THROUGH THE DEVELOPMENT
OF ADVANCED AMERICAN TECHNOLOGIES. WE WILL CONTINUE TO DELIVER THE MOST POWERFUL AND COST EFFECTIVE
APPLICATIONS FOR OUR TECHNOLOGIES.
MISSION
WE WILL MAKE THEM AVAILABLE TO CLINICIANS AND EXPECTANT MOTHERS THROUGHOUT THE WORLD.
WE EXPECT OUR TECHNOLOGIES AND THEIR INNOVATIVE APPLICATIONS TO IMPROVE THE HEALTH OF MOTHERS, REDUCE
COSTS OF PRETERM BIRTH AND ITS ASSOCIATED COMPLICATIONS,
AND, ULTIMATELY
Resulting in HEALTHY AND HAPPY BABIES.
OUR COMPETITIVE ADVANTAGE AND PRINCIPLES OF OPERATION ARE BASED ON PRACTICING ETHICAL VALUES, AMERICAN
INGENUITY, TEAMWORK, COLLABORATION, AND EXCELLENCE IN PERFORMANCE.
 Pregnancy monitoring/management hasn’t evolved since the 1970’s
 Existing monitoring products have legacy of performance/safety
issues
 Outdated, inaccurate technology leads to significantly higher costs
for the patient, providers and payers
 Unnecessary hospital/clinic visits for “false labor” - 50% of patients
admitted for preterm labor are not in true labor
 20% of symptomatic patients diagnosed as not being in true preterm
labor will delivery prematurely
 No monitoring products available to lower cost venues such as the
home
 Increasing incidence of obesity in pregnant population driving the
demand for monitoring technology that is accurate for obese patients
 Patient discomfort – Tight straps and frequent sensor relocation
Improving Pregnancy Management Leads to
the Solution of These Problems
 FDA cleared SureCALL® Labor Monitor ® – pregnancy management
through the accurate and objective monitoring of uterine
contractions
 Well-established, safe, accurate, noninvasive, comfortable, and
readily understood electromyography
 Identifies true labor versus false labor – studies show up to 100%
accuracy
 Predicts the onset of delivery – studies show up to 100% accuracy
up to 14 days in advance
 Identifies and manages high risk pregnancy patients as early as 100
days out
 Assists in the determination for Cesarean delivery
 Accurate and cost-effective remote monitoring through wireless
telemetry and cellular technology providing preterm patient
monitoring at home
 Accurately and objectively monitor obese patients
AMI’s CLINICAL SOLUTION
 Accurately - Monitors Uterine Contractions
 Identifies - True Labor vs. False Labor
 Non-invasive - Detects Electrical Signals From the Uterus
 Comfortable - Suitable for Ambulatory and Home Use
 Patient Body Mass - No Limitations
 Over 1,700 Patient Recordings - Completed
 Mobile Design - Wireless, Remote, Transmits Via Cell Phone App
 Replaces Existing Technology - Tocodynamometer and IUPC
 Predicts Delivery in Research Studies – Up to 14 Days in Advance
 Identifies High Risk Patients in Research Studies – As early as 100 Days
Clinic Wearable Remote
Superior Pregnancy
Management Through
Improved Uterine
Monitoring
 Makes existing technology obsolete
 1,700 SureCALL® patient trials ~ up to 100% accuracy
 FDA cleared for term labor
 FDA application in process for preterm labor
$1 Billion
Annual Global Market
 Approximately 100% of USA patients are monitored
 Expanding market with new, advanced applications
Compelling Consumables
Driven Economic Model
 Favorable margins on disposables
 Favorable margins on hardware
Direct Path to
Commercialization in
Multiple End Markets
 Replaces existing technology - hospital and clinic
market
 Expands market with addition of new applications
 Expands existing home monitoring market
 Open new markets – ambulatory, EMS, urgent care
Significantly Lower Cost of
Today’s “Standard of Care”
 Reduce hospital/doctor visits for “false labor”
 Accurate monitoring of high risk patients at home via
wireless remote cellular technology
Commercialization
 Marketing has been initiated – commercial acceptance
validated
INVESTMENT HIGHLIGHTS
FDA Cleared
for
Term Labor Patients
Comfortable for
Patients
No Tight Straps
No Repositioning
Disposable Electrodes
Applied to the Surface
of the Patient’s
Abdomen
Short Learning Curve
for Clinicians
5 – 15 Minutes
Non-invasive
Electromyography
Technology
Accurately Assess
Uterine Electrical
Activity in Real Time
No BMI Limitations
E-Z Application for
Clinician
Replaces
Invasive Intrauterine
Pressure Catheter and
Inaccurate
Tocodynamometer
Produces Cost Savings
and
Integrable Into
Electronic Medical
Records
Integrated Fetal Heart
Monitor and Pulse
Oximeter – Maternal
Heart Rate
 1,700+ Patient recordings completed
 60+ Published peer-reviewed technical articles and book chapters
 120+ technical abstracts and professional society presentations
SureCALL® CLINIC MODEL
Couples Wirelessly to
a Cell Phone,
Transmitting Data to an
OB, Clinic or Hospital
Light, Portable and
Wearable
Immediate Opportunity
to Expand Monitoring
to Home Market,
Reducing Hospital
Visits
Accurate, Comfortable
and Non-invasive
Sends Data Anywhere
There is a Cell
Connection
Significantly Lower the
Cost of Monitoring
High Risk Patients
SureCALL® Wearable Remote Monitor
SureCALL® WEARABLE
REMOTE MODEL
System Architecture
Patient
Cellular
Phone
Wearable
Device
Storage
Server
Doctor
Monitoring Station
Hospital / Clinic /
Monitor Service
Wearable Remote SureCALL® Labor Monitor®
Electronic Medical
Records
 Offers the precision and accuracy of the clinic model in a handheld-
sized wearable package
 Designed to expand the telemedicine capabilities in obstetrical care
 Will play a key part in alleviating the pressure on overburdened
healthcare systems by cutting down on unnecessary hospital visits
 Allow consumers and practitioners access to reliable precision
uterine monitor nearly anywhere with nearly instantaneous results
 Reliably capture a mother’s labor contractions in an easy to use and
completely non-invasive fashion
 Recordings are pushed to a proprietary cellular phone app via the
cloud where it is then stored and analyzed by the AMI web
application
 Practitioners, monitoring services, medical record systems, and
patients can access the monitoring results
SureCALL® Wearable Remote Monitor
Category SureCALL Toco IUPC
PREGNANCY MANAGEMENT
Identify True Labor vs. False Labor with 100% accuracy – Term Labor Patients Yes No No
Identify True Labor vs. False Labor with 100% accuracy – Preterm Labor Patients Yes No No
Objective Monitoring and Measurement of Normal/Abnormal Function of the Cervix Yes No No
Wearable – Constant Monitoring Without Requiring Repositioning Yes No No
Identifying and Managing High Risk Pregnancy Patients Yes No No
Predict Delivery – Capable up to 100% Accuracy out to 14 days in advance Yes No No
Assists in Determining Need For and Managing Cesarean deliveries Yes No No
Continuous Monitoring Capability Through Delivery Yes No No
Predict Success of Pharmacologic Treatments Used to Stimulate or Inhibit the Birthing
Process
Yes No No
Display of the Mother’s Voluntary “Push” w/ Natural Uterine Contractions Yes No No
SAFETY/RISK
Non-Invasive Yes Yes No
Avoids Infection Risk Yes Yes No
Monitor High Body Mass Index (BMI) Patients Yes No Yes
COMFORT
Surface Electrodes and Beltless Yes No No
Delivers Patient Comfort without Tight Strap of Pressure Gauge Yes No N/A
CONVENIENCE
Home Care Wearable / Ambulatory Use – Wireless Telemetry / Cellular technology -
Accurate / Cost Effective
Yes No No
Superior and More Cost Effective Technology Replaces Tocodynamometer
and Intrauterine Pressure Catheter
SureCALL® Labor Monitor®
PREDICTING DAYS TO DELIVERY
Variable 1 DAY 2 DAYS 4 DAYS 7 DAYS 14 DAYS
PPV (%) 100% 100% 100% 100% 100%
NPV (%) 100% 96% 88% 96% 90%
SOURCE: “Noninvasive Uterine Electromyography for Prediction of Preterm Delivery”;
American Journal of Obstetrics & Gynecology, March, 2011
Note:
1. 88 patients are included in this study
2. At the time of SureCALL® measurements (≤ 24 hours after admission for Preterm Labor), contractions
were detected by Toco in only 30% (26/88) of patients; conversely, contractions were easily detected
by SureCALL®
USES AND POTENTIAL BENEFITS OF THE
SureCALL® LABOR MONITOR ®
Clinical Condition Clinical Use Potential Benefits
Antepartum Predict preterm delivery Prevent preterm
delivery and improve
perinatal outcome.
Early Labor Differentiate between Prevent unnecessary
false and true labor. admissions.
Preterm Contractions Determine need for Prevent unnecessary
tocolysis. use of tocolytics and
decrease cost.
Cervical Rule out the presence of Better define Incompetence
subclinical uterine candidates for post-
electrical activity. cerclage tocolysis.
Better understanding
of etiologies.
Induction of Labor Predict success of Prevent unnecessary
induction. prolonged inductions.
More objective and
accurate analysis of
uterine activity.
Augmentation of Labor More objective and Decrease numbers of
accurate analysis of cesarean sections due
uterine activity. to inappropriate use of
oxytocin.
Better way to monitor
and adjust oxytocin
infusion.
Failure to Progress More objective and Decrease numbers of
accurate analysis of cesarean sections due to
uterine activity. inappropriate use of
oxytocin.
Clinical Condition Clinical Use Potential Benefits
USES AND POTENTIAL BENEFITS OF THE
SureCALL® LABOR MONITOR ®
Clinical Condition Clinical Use Potential Benefits
Tocolysis Predict success of Prevent complications
tocolysis. from tocolytics.
More objective and Decrease time on
accurate analysis of tocolytics.
uterine activity.
Improved method to Predict response
monitor and adjust augmentation
tocolytic therapy.
Labor Decreased need for Decreased risk of
invasive monitoring. maternal infection.
Decreased risk of
vaginal infection.
Improved response
time with
dysfunctional
labor.
USES AND POTENTIAL BENEFITS OF THE
SureCALL® LABOR MONITOR ®
 Invented and Initially Developed at
University of Texas Medical Branch - Galveston
 Starting 2004, Development Advanced by AMI
 Acquires EMG Signals Abdominally
 Non-invasive from Abdominal Surface Electrodes
 Comfortable for Patients
 Accuracy of Contraction Frequency, Duration, and Intensity – 100%
 Predict Delivery – Up to 14 Days in Advance
 Over 1,700 Patient Studies Completed
 Multiple Patents Issued & Pending – USA & International
 Cleared to Market by FDA for Term Patients
 Enables Replacement of Existing Uterine Monitors
 Limited Marketing Initiated
SureCALL® Technology
MANAGEMENT EXPERIENCE: In Technology, Startups And Operations
TECHNOLOGY ADVANTAGE:
• Platform Technology
• Clinically Proven – Over 2,200 Patient Studies From Multiple Institutions
• Term Labor - SureCALL® FDA Cleared
• Preterm Labor – SureCALL® Studies Completed Ready For FDA Filing on
Safety Study Competition – Q1 2016
• Wearable Remote – SureCALL® Clinically Proven – FDA Filing Q1 2016
• Development Of Advanced Technical Applications in the Pipeline
INTELLECTUAL PROPERTY PROTECTED: Multiple Patents, Issued and Applied,
Protecting Priority Technology USA and World
FINANCIAL PERFORMANCE EXCELLENCE:
• Instruments with multiple applications
• Consumables, Service Contracts
• Opportunities for – leasing, financing, service center operation
• High ROI
AMI HAS INITIATED LIMITED COMMERCIAL SALES
IN SUMMARY
AMI IS POSITIONED FOR RAPID GROWTH OFFERING
HIGH MARGINS STARTING NOW
WITH
SureCALL® Business Plan
I. Technology
II. Captures Existing
Markets
III. Product Development
IV. Develop New Markets
V. Profitability
• Proven Superior
• Replace TOCO/IUPC
- Technical Superiority
- Cost Effective
- Patient Friendly
• Advanced Applications
Validated
• Expanded Application
• Home Care
• High Margins
IN SUMMARY
AMI IS POSITIONED FOR RAPID GROWTH OFFERING
HIGH MARGINS STARTING NOW
RESULT
PRODUCING A WIN – WIN – WIN
RRT HAS INITIATED LIMITED COMMERCIAL SALES
RAPIDLY IMPROVING THE STANDARD OF CARE FOR PREGNANCY
MANAGEMENT THROUGH ADVANCED, COST EFFECTIVE TECHNOLOGY ……
BENEFITING ALL MAJOR STAKEHOLDERS
PATIENTS – MOTHER AND BABY
IMPROVED OUTCOMES AND REDUCED COSTS
PROVIDERS – HOSPITAL AND DOCTOR
IMPROVED PATIENT CARE, SAFETY AND REDUCED COSTS
PAYORS AND SOCIETY – SIGNIFICANTLY REDUCED COSTS
HEALTHCARE COSTS AND SOCIETAL BURDEN
IN SUMMARY
Thank You for Your
Interest
1770 ST. JAMES PLACE, SUITE 600, HOUSTON, TEXAS 77056
Tel: 713-680-0200
Fax: 713-680-0299
advancedmaternityinnovations.com
info@innovalp.com
In are interested in investing with Advanced
Maternity Innovations, please follow the
I’m Interested link.

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AMI Solution Presentation

  • 1. © 2016 Advanced Maternity Innovations, LP - All Rights Reserved American Medical Technologies, Improving Pregnancy Management
  • 2. This presentation and the related materials include “forward-looking statements”. The opinions, forecasts, projections, or other statements (“statements”) other than statements of historical fact, are forward-looking statements. Although Reproductive Research Technologies, LP (“RRT”) believes that the expectations reflected in such forward-looking statements are reasonable, it is highly likely that actual results and timing will vary, and may vary substantially, from plans and projections shown. Many of the factors which will determine actual results are not within the control of RRT. A high degree of risk and uncertainty is inherent in the development of the RRT business, technology systems and other product applications. An investment in RRT is subject to substantial risks. No person should invest in RRT who is not in a position to hold the investment indefinitely or sustain the loss of his/her entire investment. Please review this information carefully and request from RRT any additional information deemed to be necessary to fully evaluate the risks and the merits of an investment in RRT. Many of the factors which will determine actual results are not within the control of the general partner. This investment is suitable only for persons who have substantial financial resources. No liquidity event may occur and there may not be distributions. IMPORTANT NOTICE
  • 3. ADVANCED MATERNITY INNOVATIONS, LP American Medical Technologies, Improving Pregnancy Management AS AN AMERICAN MEDICAL DEVICE TECHNOLOGY INNOVATOR AND DEVELOPER, WE INTEND TO LEAD THE WORLDWIDE TECHNOLOGY REVOLUTION TO SIGNIFICANTLY IMPROVE THE QUALITY OF MATERNITY CARE AND THE DELIVERY OF NEW BORN BABIES, RESULTING IN COST EFFECTIVE NEW AND ELEVATED STANDARDS OF CARE IN PREGNANCY MANAGEMENT. VISION OUR ULTIMATE GOAL IS ASSISTING CLINICIANS AND EXPECTANT MOTHERS, THROUGH ADVANCED AND INNOVATIVE TECHNOLOGY, IN THE DELIVERY OF HEALTHY, HAPPY BABIES BY HEALTHY, HAPPY MOTHERS DELIVERING A WIN FOR ALL WE INTEND TO LEAD IN THE FIGHT TO REDUCE PRETERM BIRTH, RESULTING IN A POSITIVE IMPACT ON PATIENTS, PROVIDERS, PAYORS, OUR PARTNERS, AND SOCIETY AT LARGE.
  • 4. ADVANCED MATERNITY INNOVATIONS, LP American Medical Technologies, Improving Pregnancy Management WE WILL LEAD THE MATERNITY CARE REVOLUTION BY IMPROVING PREGNANCY MANAGEMENT THROUGH THE DEVELOPMENT OF ADVANCED AMERICAN TECHNOLOGIES. WE WILL CONTINUE TO DELIVER THE MOST POWERFUL AND COST EFFECTIVE APPLICATIONS FOR OUR TECHNOLOGIES. MISSION WE WILL MAKE THEM AVAILABLE TO CLINICIANS AND EXPECTANT MOTHERS THROUGHOUT THE WORLD. WE EXPECT OUR TECHNOLOGIES AND THEIR INNOVATIVE APPLICATIONS TO IMPROVE THE HEALTH OF MOTHERS, REDUCE COSTS OF PRETERM BIRTH AND ITS ASSOCIATED COMPLICATIONS, AND, ULTIMATELY Resulting in HEALTHY AND HAPPY BABIES. OUR COMPETITIVE ADVANTAGE AND PRINCIPLES OF OPERATION ARE BASED ON PRACTICING ETHICAL VALUES, AMERICAN INGENUITY, TEAMWORK, COLLABORATION, AND EXCELLENCE IN PERFORMANCE.
  • 5.
  • 6.  Pregnancy monitoring/management hasn’t evolved since the 1970’s  Existing monitoring products have legacy of performance/safety issues  Outdated, inaccurate technology leads to significantly higher costs for the patient, providers and payers  Unnecessary hospital/clinic visits for “false labor” - 50% of patients admitted for preterm labor are not in true labor  20% of symptomatic patients diagnosed as not being in true preterm labor will delivery prematurely  No monitoring products available to lower cost venues such as the home  Increasing incidence of obesity in pregnant population driving the demand for monitoring technology that is accurate for obese patients  Patient discomfort – Tight straps and frequent sensor relocation Improving Pregnancy Management Leads to the Solution of These Problems
  • 7.  FDA cleared SureCALL® Labor Monitor ® – pregnancy management through the accurate and objective monitoring of uterine contractions  Well-established, safe, accurate, noninvasive, comfortable, and readily understood electromyography  Identifies true labor versus false labor – studies show up to 100% accuracy  Predicts the onset of delivery – studies show up to 100% accuracy up to 14 days in advance  Identifies and manages high risk pregnancy patients as early as 100 days out  Assists in the determination for Cesarean delivery  Accurate and cost-effective remote monitoring through wireless telemetry and cellular technology providing preterm patient monitoring at home  Accurately and objectively monitor obese patients AMI’s CLINICAL SOLUTION
  • 8.  Accurately - Monitors Uterine Contractions  Identifies - True Labor vs. False Labor  Non-invasive - Detects Electrical Signals From the Uterus  Comfortable - Suitable for Ambulatory and Home Use  Patient Body Mass - No Limitations  Over 1,700 Patient Recordings - Completed  Mobile Design - Wireless, Remote, Transmits Via Cell Phone App  Replaces Existing Technology - Tocodynamometer and IUPC  Predicts Delivery in Research Studies – Up to 14 Days in Advance  Identifies High Risk Patients in Research Studies – As early as 100 Days Clinic Wearable Remote
  • 9. Superior Pregnancy Management Through Improved Uterine Monitoring  Makes existing technology obsolete  1,700 SureCALL® patient trials ~ up to 100% accuracy  FDA cleared for term labor  FDA application in process for preterm labor $1 Billion Annual Global Market  Approximately 100% of USA patients are monitored  Expanding market with new, advanced applications Compelling Consumables Driven Economic Model  Favorable margins on disposables  Favorable margins on hardware Direct Path to Commercialization in Multiple End Markets  Replaces existing technology - hospital and clinic market  Expands market with addition of new applications  Expands existing home monitoring market  Open new markets – ambulatory, EMS, urgent care Significantly Lower Cost of Today’s “Standard of Care”  Reduce hospital/doctor visits for “false labor”  Accurate monitoring of high risk patients at home via wireless remote cellular technology Commercialization  Marketing has been initiated – commercial acceptance validated INVESTMENT HIGHLIGHTS
  • 10. FDA Cleared for Term Labor Patients Comfortable for Patients No Tight Straps No Repositioning Disposable Electrodes Applied to the Surface of the Patient’s Abdomen Short Learning Curve for Clinicians 5 – 15 Minutes Non-invasive Electromyography Technology Accurately Assess Uterine Electrical Activity in Real Time No BMI Limitations E-Z Application for Clinician Replaces Invasive Intrauterine Pressure Catheter and Inaccurate Tocodynamometer Produces Cost Savings and Integrable Into Electronic Medical Records Integrated Fetal Heart Monitor and Pulse Oximeter – Maternal Heart Rate  1,700+ Patient recordings completed  60+ Published peer-reviewed technical articles and book chapters  120+ technical abstracts and professional society presentations SureCALL® CLINIC MODEL
  • 11. Couples Wirelessly to a Cell Phone, Transmitting Data to an OB, Clinic or Hospital Light, Portable and Wearable Immediate Opportunity to Expand Monitoring to Home Market, Reducing Hospital Visits Accurate, Comfortable and Non-invasive Sends Data Anywhere There is a Cell Connection Significantly Lower the Cost of Monitoring High Risk Patients SureCALL® Wearable Remote Monitor SureCALL® WEARABLE REMOTE MODEL
  • 12. System Architecture Patient Cellular Phone Wearable Device Storage Server Doctor Monitoring Station Hospital / Clinic / Monitor Service Wearable Remote SureCALL® Labor Monitor® Electronic Medical Records
  • 13.  Offers the precision and accuracy of the clinic model in a handheld- sized wearable package  Designed to expand the telemedicine capabilities in obstetrical care  Will play a key part in alleviating the pressure on overburdened healthcare systems by cutting down on unnecessary hospital visits  Allow consumers and practitioners access to reliable precision uterine monitor nearly anywhere with nearly instantaneous results  Reliably capture a mother’s labor contractions in an easy to use and completely non-invasive fashion  Recordings are pushed to a proprietary cellular phone app via the cloud where it is then stored and analyzed by the AMI web application  Practitioners, monitoring services, medical record systems, and patients can access the monitoring results SureCALL® Wearable Remote Monitor
  • 14. Category SureCALL Toco IUPC PREGNANCY MANAGEMENT Identify True Labor vs. False Labor with 100% accuracy – Term Labor Patients Yes No No Identify True Labor vs. False Labor with 100% accuracy – Preterm Labor Patients Yes No No Objective Monitoring and Measurement of Normal/Abnormal Function of the Cervix Yes No No Wearable – Constant Monitoring Without Requiring Repositioning Yes No No Identifying and Managing High Risk Pregnancy Patients Yes No No Predict Delivery – Capable up to 100% Accuracy out to 14 days in advance Yes No No Assists in Determining Need For and Managing Cesarean deliveries Yes No No Continuous Monitoring Capability Through Delivery Yes No No Predict Success of Pharmacologic Treatments Used to Stimulate or Inhibit the Birthing Process Yes No No Display of the Mother’s Voluntary “Push” w/ Natural Uterine Contractions Yes No No SAFETY/RISK Non-Invasive Yes Yes No Avoids Infection Risk Yes Yes No Monitor High Body Mass Index (BMI) Patients Yes No Yes COMFORT Surface Electrodes and Beltless Yes No No Delivers Patient Comfort without Tight Strap of Pressure Gauge Yes No N/A CONVENIENCE Home Care Wearable / Ambulatory Use – Wireless Telemetry / Cellular technology - Accurate / Cost Effective Yes No No Superior and More Cost Effective Technology Replaces Tocodynamometer and Intrauterine Pressure Catheter SureCALL® Labor Monitor®
  • 15. PREDICTING DAYS TO DELIVERY Variable 1 DAY 2 DAYS 4 DAYS 7 DAYS 14 DAYS PPV (%) 100% 100% 100% 100% 100% NPV (%) 100% 96% 88% 96% 90% SOURCE: “Noninvasive Uterine Electromyography for Prediction of Preterm Delivery”; American Journal of Obstetrics & Gynecology, March, 2011 Note: 1. 88 patients are included in this study 2. At the time of SureCALL® measurements (≤ 24 hours after admission for Preterm Labor), contractions were detected by Toco in only 30% (26/88) of patients; conversely, contractions were easily detected by SureCALL®
  • 16. USES AND POTENTIAL BENEFITS OF THE SureCALL® LABOR MONITOR ® Clinical Condition Clinical Use Potential Benefits Antepartum Predict preterm delivery Prevent preterm delivery and improve perinatal outcome. Early Labor Differentiate between Prevent unnecessary false and true labor. admissions. Preterm Contractions Determine need for Prevent unnecessary tocolysis. use of tocolytics and decrease cost. Cervical Rule out the presence of Better define Incompetence subclinical uterine candidates for post- electrical activity. cerclage tocolysis. Better understanding of etiologies.
  • 17. Induction of Labor Predict success of Prevent unnecessary induction. prolonged inductions. More objective and accurate analysis of uterine activity. Augmentation of Labor More objective and Decrease numbers of accurate analysis of cesarean sections due uterine activity. to inappropriate use of oxytocin. Better way to monitor and adjust oxytocin infusion. Failure to Progress More objective and Decrease numbers of accurate analysis of cesarean sections due to uterine activity. inappropriate use of oxytocin. Clinical Condition Clinical Use Potential Benefits USES AND POTENTIAL BENEFITS OF THE SureCALL® LABOR MONITOR ®
  • 18. Clinical Condition Clinical Use Potential Benefits Tocolysis Predict success of Prevent complications tocolysis. from tocolytics. More objective and Decrease time on accurate analysis of tocolytics. uterine activity. Improved method to Predict response monitor and adjust augmentation tocolytic therapy. Labor Decreased need for Decreased risk of invasive monitoring. maternal infection. Decreased risk of vaginal infection. Improved response time with dysfunctional labor. USES AND POTENTIAL BENEFITS OF THE SureCALL® LABOR MONITOR ®
  • 19.  Invented and Initially Developed at University of Texas Medical Branch - Galveston  Starting 2004, Development Advanced by AMI  Acquires EMG Signals Abdominally  Non-invasive from Abdominal Surface Electrodes  Comfortable for Patients  Accuracy of Contraction Frequency, Duration, and Intensity – 100%  Predict Delivery – Up to 14 Days in Advance  Over 1,700 Patient Studies Completed  Multiple Patents Issued & Pending – USA & International  Cleared to Market by FDA for Term Patients  Enables Replacement of Existing Uterine Monitors  Limited Marketing Initiated SureCALL® Technology
  • 20. MANAGEMENT EXPERIENCE: In Technology, Startups And Operations TECHNOLOGY ADVANTAGE: • Platform Technology • Clinically Proven – Over 2,200 Patient Studies From Multiple Institutions • Term Labor - SureCALL® FDA Cleared • Preterm Labor – SureCALL® Studies Completed Ready For FDA Filing on Safety Study Competition – Q1 2016 • Wearable Remote – SureCALL® Clinically Proven – FDA Filing Q1 2016 • Development Of Advanced Technical Applications in the Pipeline INTELLECTUAL PROPERTY PROTECTED: Multiple Patents, Issued and Applied, Protecting Priority Technology USA and World FINANCIAL PERFORMANCE EXCELLENCE: • Instruments with multiple applications • Consumables, Service Contracts • Opportunities for – leasing, financing, service center operation • High ROI AMI HAS INITIATED LIMITED COMMERCIAL SALES IN SUMMARY AMI IS POSITIONED FOR RAPID GROWTH OFFERING HIGH MARGINS STARTING NOW WITH
  • 21. SureCALL® Business Plan I. Technology II. Captures Existing Markets III. Product Development IV. Develop New Markets V. Profitability • Proven Superior • Replace TOCO/IUPC - Technical Superiority - Cost Effective - Patient Friendly • Advanced Applications Validated • Expanded Application • Home Care • High Margins IN SUMMARY
  • 22. AMI IS POSITIONED FOR RAPID GROWTH OFFERING HIGH MARGINS STARTING NOW RESULT PRODUCING A WIN – WIN – WIN RRT HAS INITIATED LIMITED COMMERCIAL SALES RAPIDLY IMPROVING THE STANDARD OF CARE FOR PREGNANCY MANAGEMENT THROUGH ADVANCED, COST EFFECTIVE TECHNOLOGY …… BENEFITING ALL MAJOR STAKEHOLDERS PATIENTS – MOTHER AND BABY IMPROVED OUTCOMES AND REDUCED COSTS PROVIDERS – HOSPITAL AND DOCTOR IMPROVED PATIENT CARE, SAFETY AND REDUCED COSTS PAYORS AND SOCIETY – SIGNIFICANTLY REDUCED COSTS HEALTHCARE COSTS AND SOCIETAL BURDEN IN SUMMARY
  • 23. Thank You for Your Interest 1770 ST. JAMES PLACE, SUITE 600, HOUSTON, TEXAS 77056 Tel: 713-680-0200 Fax: 713-680-0299 advancedmaternityinnovations.com info@innovalp.com In are interested in investing with Advanced Maternity Innovations, please follow the I’m Interested link.