This document discusses conjunctivitis (inflammation of the conjunctiva). It begins by defining the conjunctiva and describing typical symptoms and signs of conjunctivitis such as redness, discharge, irritation and pain. It then differentiates between bacterial, viral, allergic and other causes of conjunctivitis, providing details on common causes, symptoms and treatment for each type. Trachoma, a leading cause of blindness, is also explained. The document concludes with sections on prevention of conjunctivitis through proper hand washing and avoiding sharing personal items with infected individuals.
3. LEARNING OUTCOMES
3
After attending this presentation, the audience will be
able to:
Differentiate different types of conjunctivitis
Interpret signs and symptoms of different types of
conjunctivitis
Devise management of different types of
conjunctivitis
Design prevention plan for conjunctivitis
4. THE CONJUNCTIVA
Palpebral or tarsal
conjunctiva
Bulbar or ocular
conjunctiva
Fornix conjunctiva
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Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap2, page 17, London, RE&PP Ltd.
5. CONJUNCTIVITIS
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Irritation
Itching
Watering and
discharge
Redness
Discomfort
Pain and photophobia
in keratoconjunctivitis
Vasodilatation
Increased secretions
Edema
Follicles
Papillae
Keratinization
Membrane formation
Scarring (fibrosis)
Typical symptoms Typical signs
Infection or inflammation of the conjunctiva
More common in hot climates
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 83, London, RE&PP Ltd.
6. BACTERIAL CONJUNCTIVITIS
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The bacteria may invade
a normal, healthy
conjunctiva to produce a
primary bacterial
conjunctivitis
The bacteria may invade
because the conjunctival
defense against
infection is weakened,
called secondary
bacterial conjunctivitis
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 86, London, RE&PP Ltd.
7. BACTERIAL CONJUNCTIVITIS
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SIGNS AND SYMPTOMS
Key characteristic,
mucopurulent discharge
In severe cases it is like
yellow pus
In mild cases the eyelids
may be stuck together on
waking
There is always
vasodilatation of
conjunctiva
In severe cases there may
be chemosis of the
conjunctiva, edema of
eyelids and general
malaise
COMMON CAUSATIVE AGENTS
Staphylococcus cause acute
primary conjunctivitis
Haemophilus influenza cause
seasonal conjunctivitis
Gonococcus comes form
genital discharges and cause
severe conjunctivitis
Moraxella lacunata causes
mild angular conjunctivitis
Other bacteria,
pneumococcus,
meningococcus,
streptococcus etc.
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 88, London, RE&PP Ltd.
8. TRACHOMA
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Trachoma ( Ancient
Greek “ Rough eye”)
Leading infectious
cause of blindness
world wide
WHO estimates 2.2
million people visually
impaired world wide
due to trachoma
Caused by one of the
chlamydia group
organism the “
chlamydia trachomatis”
WHO.Trachoma fact sheet N*382,March 2014
9. 9
Symptoms
Mild itching and irritation of the
eye
Watering
Mucopurrulent discharge from
the eye
As the disease progresses, later
trachoma symptoms include:
Marked light sensitivity
(photophobia)
Blurred vision
Eye pain
Signs
Conjunctiva:
Follicular conjunctivitis (tarsal
conj, fornices)
Limbal follicles
Conjunctival scarring
Herbert's pits (after resolution
of follicles)
TRACHOMA
WHO.Trachoma fact sheet N*382,March 2014
12. TRACHOMA
Treatment
Tetracycline, topical (2 months) and oral (3 weeks)
Oral azithromycin
SAFE Strategy
Surgery for correction of trichiasis
Antibiotics
Face cleaning
Environmental improvement
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WHO.Trachoma fact sheet N*382,March 2014 (GET 2020)
13. VIRAL CONJUNCTIVITIS
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Viruses live in the epithelial
cells and often invade the
epithelial cells of the cornea
Viruses live inside the body
cells so they are all immune to
antibiotics
Disease may be so mild that it
is impossible to recognize it
clinically
It may be a severe and
disabling condition
TYPICAL SIGN AND SYMPTOMS
Gritty foreign body sensation
and photophobia
Watery and not purulent
secretions called serous
secretion
Blood vessels are dilated and
there is hypertrophy of the
lymphoid follicles
There may be papillary
hypertrophy on the upper tarsal
conjunctiva
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 89, London, RE&PP Ltd.
14. ADENOVIRUS CONJUNCTIVITIS
Most common viral infection of the conjunctiva
There are many different strains of the virus, all the
strains are very contagious
Usually bilateral but often affects one eye more
severely than other
Superficial punctate keratitis and psuedomembrane
are specific signs
The infection is easily spreads from person to
person by direct contact specially in workers
examining eyes 14
VIRAL CONJUNCTIVITIS
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 90, London, RE&PP Ltd.
15. VIRAL CONJUNCTIVITIS
MEASLES
Generalized viral infection
Also invades the conjunctival and corneal epithelium
It can cause serious corneal ulceration and blindness
MOLLUSCUM CONTAGIOSUM
Viral wart which appears on the margins of the eyelids
Virus particles are discharged from the wart into the
conjunctiva and cause a typical follicular conjunctivitis
Treatment is to remove the wart
either by excision, cautery or curettage
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Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 91, London, RE&PP Ltd.
16. VIRAL CONJUNCTIVITIS
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HERPES SIMPLEX
VIRUS
Wide spread virus
Cause follicular
conjunctivitis, corneal ulcer,
multiple vesicles on the
face, mouth, or eyelids
Spread by direct contact
The virus remain dormant
until years and cause
recurrent infections
Anti viral treatment
Debridement and chemical
cauterization techniques are
used for corneal epithelial
removal
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 88, London, RE&PP Ltd.
17. GRANULOMATOUS CONJUNCTIVITIS
Also called parinaud’s syndrome
Unilateral with a local inflammatory granuloma in
the conjunctiva
Usually means the conjunctiva has become by
chance the route of entry into the body for some
micro organism
Possible causes:
Tuberculosis
Syphilis
Actinomycosis ( fungal disease)
Sporotrichosis ( fungal disease)
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Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 88, London, RE&PP Ltd.
18. ALLERGIC CONJUCTIVITIS
It can occur in four forms
A. Vernal conjunctivitis
Originally called spring catarrh
May occur through out the year
Common in children
Not caused by specific allergen
Most likely agent is some material in the
atmosphere such as pollen
Belong to same group of diseases as allergic
rhinitis, asthma and eczema atopic diseases
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Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 93, London, RE&PP Ltd.
19. ALLERGIC CONJUCTIVITIS
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SYMPTOMS AND SIGNS
Severe and persistent itching
and irritation in both eyes
Feeling string or worms in the
eyes
Sticky white discharge
Thickening of conjunctiva with
formation of papillae
Giant papillae in the advance
stage, spaces between papillae
filled with mucus
Cobblestone appearance
Superficial punctate keratitis
Shield ulcer
MANAGEMENT
Steroids
Antihistamine
Cryotheraphy
Diathermy and cautery
Beta radiation given with a
strontium 90 applicator
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 94, London, RE&PP Ltd.
20. ALLERGIC CONJUCTIVITIS
B. Hay fever conjunctivitis
Acute allergic reaction to pollen in the air
Usually associated with acute rhinitis
Non of the structural changes like in the vernal conjunctivitis
C. Phlyctenular conjunctivitis
Phlycten is Greek word for a blister
Localized hypersensitivity reaction to bacterial
proteins in the bloodstream, mostly tubercular
Phlycten appears as a raised pinkish nodule
surrounded by an area of hyperemia
It then develops a necrotic grey center surrounded
by reactive inflammation
D. Allergies to drugs and cosmetics
Medications , chemical preservatives, cosmetics can provoke an
allergic reaction
Diagnosed by taking careful history
Stop the provoking agent
Topical steroids will relieve the symptoms
20
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 95, London, RE&PP Ltd.
21. ENDOGENOUS CONJUNCTIVITIS
Cause of the inflammation may be an inflammation
arising from within the body itself
Exact mechanism is not known but in most cases it
is a type of auto immune disease
KERATOCONJUNCTIVITIS SICCA
Common specially in old people
Often associated with rheumatoid arthritis
The lacrimal gland and accessory conjunctival
glands become inflammed so produce fewer tears
The eyes are sore and gritty
Schirmer’s test 21
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 97, London, RE&PP Ltd.
22. ENDOGENOUS CONJUNCTIVITIS
OCULAR PEMPHIGOID
Some times called essential shrinkage of the
conjunctiva
Gradual shrinkage and fibrosis of the conjunctiva
Symblepharon in advance cases
STEVEN-JOHNSON SYNDROME
Acute ulceration of the conjunctiva and other mucous
membranes like the mouth and vagina
Followed by severe scarring of the membranes
Often caused by sensitivity to drugs, particularly
sulphonamides
Topical and systemic steroids in acute stage may help
22
Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 98, London, RE&PP Ltd.
23. NEONATAL CONJUCTIVITIS
( OPHTHALMIA NEONATORUM)
Conjunctivitis in a newborn child
GONOCOCCUS is most serious cause
Baby may be infected during delivery if the
mother genital tract is infected
Cause acute conjunctivitis within the first few
days of birth
May cause corneal ulceration, scarring and
eventually blindness
CHLAMYDIA, Organism similar to trachoma
May be present in the female genital tract
Cause conjunctivitis within the first 2 weeks of
birth
STAPHYLOCOCCUS and other organism of a
non genital origin may also infect the infant
conjunctiva
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Smith, J. S. (1997). Eye diseases in hot climates (third edition),chap6, page 99, London, RE&PP Ltd.
24. PREVENTION OF CONJUNCTIVITIS
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If you have infectious
conjunctivitis, you can
help limit its spread to
other people by following
these steps:
Wash your hands often
with soap and warm
water
Avoid touching or
rubbing your eyes
Wash any discharge
from around the eyes
several times a day
Wash hands after
applying eye drops or
ointment
25. PREVENTION OF CONJUNCTIVITIS
Do not use the same eye drop dispenser/bottle for
infected and non-infected eyes—even for the same
person
Wash pillowcases, sheets, washcloths, and towels in hot
water and detergent; hands should be washed after
handling such items
Avoid sharing articles like towels, blankets, and
pillowcases
Clean eyeglasses, being careful not to contaminate
items (like towels) that might be shared by other people
Do not share eye makeup, face make-up, make-up
brushes, contact lenses and containers, or eyeglasses
Do not use swimming pools
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26. PREVENTION OF CONJUNCTIVITIS
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If you are around someone
with infectious conjunctivitis,
you can reduce your risk of
infection by following these
steps:
Wash your hands often with
soap and warm water
Wash your hands after
contact with an infected
person or items he or she
uses
Do not share items used by
an infected person; for
example, do not share
pillows, washcloths, towels,
eye drops, eye or face
makeup, and eyeglasses
27. PREVENTION OF CONJUNCTIVITIS
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If you have infectious
conjunctivitis, there are steps you
can take to avoid re-infection
once the infection goes away:
Throw away and replace any
eye or face makeup you used
while infected
Throw away contact lens
solutions that you used while
your eyes were infected
Throw away disposable contact
lenses and cases that were
used while your eyes were
infected
Clean extended wear lenses as
directed
Clean eyeglasses and cases
that were used while infected
Mucus membrane
Composed of non-keratinized, stratified squamous epithelium, stratified columnar epithelium, goblet cells, blood vessels, fibrous tissue, and lymphatic channels
Additional cells present in the conjunctival epithelium include melanocytes, T and B cell lymphocytes
The conjunctival functions include the lubrication, immune surveillance, and prevent entrance of the microbes into the eyes
The signs vary very much according to the type of conjunctivitis
. In contrast to papillae, follicles are small, dome-shaped nodules without a prominent central vessel. Accordingly, whereas a papilla clinically appears more red on its surface and more pale at its base, a follicle appears more pale on its surface and more red at its base. Histologically, a lymphoid follicle is situated in the subepithelial region and consists of a germinal center, containing immature, proliferating lymphocytes; and surrounding corona, containing mature lymphocytes and plasma cells. The follicles in follicular conjunctivitis are typically most prominent in the inferior palpebral and forniceal conjunctiva.
The inflammation is acute, sever and usually bilateral
Primary: The disease last for 1-2 weeks then resolves spontaneously, usually without scarring
Secondary bacterial conjunctivitis usually persists with chronic recurrent symptoms until the primary cause is treated