2. Quanttus
Biovotion
Freedom
Medical
Swiss-based medical device company
provides solutions for continous, non-
invasive physiological monitoring. The
VSM platform is a mobile, stand alone
wearable monitoring paramteres
supported by integrated cloud services.
Winner of Nokia Sensing XCHALLENGE
2014 and awarded by the European
Commission as Europe's 'best eHealth
SMEs' 2013.
Company makes the ClearPath DS-120,
a device that scans the eye lens for
signs of autofluorescence
an early indicator of diabetes (as per a
significant number of independent peer-
reviewed studies). A quantitative
response is then made immediately
available to an optometrist and patient,
whilst also being electronically transmits
to a referal healthcare provider.
It raised $4.8million in a round of Series
C funding in May 2015.
This startup's wearable vitals monitor is
currently in clinical tests for continuously
monitoring blood pressure. Originally designed
to be worn behind the ear, the tool now
resembles other 'smart' watches on the market
and this shift is to encourage consumer-
friendly, self-management. A number of studies
have already been conducted in
Massachusetts General Hospital and it is now
scaling up for FDA clearance.
1.
2.
3.
3. Sense4Baby
Tricoder
Kit like Star Trek's
Launched in 2012, the $10million Qualcomm Tricoder
XPRIZE (a 3.5 year global competition) has just
announced its 10 finalists. The goal is to develop a
consumer-focused, mobile device capable of
diagnosing and interpreting a set of 15 medical
conditions and capturing 5 vital health metrics. It goes
without saying that the device resembles the medical
Tricoder of Star Trek fame. Will science fiction become
a reality? 10 finalists are on the right:
- Aezon, a team of student engineers
from John Hopkins University
partnering with the Center for
Bioengineering Innovation & Design.
- CloudDX, a team from medical
devices manufacturer Biosign.
- Danvantri, a team from tech
manufacturer American Megatrends
India.
- Dynamical Biomarkers Group, a
team led by Harvard medical School
professor Chung-Kang Peng.
Final Frontier Medical Devices, a
team led by the founders of Basil
Leaf Technologies
- MESI Simplifying diagnostics, a
team from diagnostic medical device
manufacturer MESI
- SCANADU, a team from Silicon
Valley-based start-up.
- SCANurse, a team from diagnostics
medical manufacturer of the same
name
- zensor, a team from clinical sensor
and electrode company Intelesens
Acquired by AirStrip, this technology was first
licensed from the Gary and Mary West Health
Institute. It is a tool to allow women to undergo
non-stress testing to monitor fetal and maternal
heart rate, contraction patterns using non-invasive
sensors at physician's offices, clinics and
ambulances. Airstrip has received FDA clearance
for patient self-administration of the system and the
University of Utah is now studying how to integrate
the platform into a healthcare system which would
allow evaluation of patient & provider satisfaction,
costs and benefits.
4.
5.
4. FitBit
LuminaCare
This small digital, wristband tracker captures how
many calories you've burned, how many minutes you
have been active and how many steps you have
taken. The technology is a good fit for studies in MS
because it is designed to track a critical indicator of
the disease - mobility.
Cloud-based predictive health analytics
platform empowers physicians to select the
right drug for patients with bacterial
infections. The company is taking advantage
of diagnostics that have shortened the time
required to identify bacterial strains from two
to three days to just a few hours. Using
prediction software, the company is tracking
how different patient profiles respond to
certain medications and thus giving more
information to the doctor.The goal is that this
software will be a short-term treatment tool
and in a long term a way of extending the
lifespan of antibiotics, which are frequently
overprescribing and spawning the evolution
of drug-resistant bacteria.
6.
Biogen, PatientsLikeMe
use to understand MS
Garmin
Medidata selected this Garmin's
vivofit device (a water-resistant, 24/7
wristband used to measure steps
taken, distance, calories burned and
hours slept) to capture patient data in
clinical trials. The company's
president remarked 'Integrating the
vivofit with the Medidata platform is
part of our ongoing efforts to unify
mHealth devices with cloud-based
technologies in a clinical trial setting'.
7.
8.
5. MC10
Medopad
AliveCor
9.
10.
11.
'Electronic skin makes your body a computer' - CNN
This company develops flexible electronic circuits that
stick directly to the skin and monitor wearer's health,
including temperature, hydration and strain. Applications
include letting an athlete know when and how much to
hydrate for peak performance, or when to apply more
sunscreen. A partnership with University of Rochester is
also developing predictive health analytics, enabling
objective, sensitive, frequent assessments of an
individual's condition to improve their health & advance
new treatments.
The company's Heart Monitor is a single-channel cardiac
event recorder, which consists of a device & app that
enables the recording and review of electrocardiograms
(ECG's). A review in imedicalapps.com described its
clinical use as a non-continuous, patient-triggered event
monitor, where by medical advice can be sort for
palpitations. Additionally it could be use for periodic post-
procedure follow-up (eg. atrial fibrillation or atrial flutter
ablation).
Offers a suite of CE certified iPad
applications that integrate health
data from existing hospital
databases and securely sends it
to medical professionals' mobile
devices. The company is
headquarted in London and the
first company to work with them
was BMI Healthcare, the largest
private hospital group in the UK
with nearly 70 centers. A recent
development has been the
launch of its Apple Watch
chemotherapy app with patients
at London's King's College
Hospital the first to trial it. The
company claims the platform
allows doctors to adjust drug
regimens in real-time "to provide
even greater levels of proactive
care and patients are provided
chemotherapy treatment tailored
specifically to them and reduces
side effect-related visits to
hospitals.
6. imPACT
Mendor
12.
13.
Stands for 'Immediate Post-Concussion
Assessment and Cognitive Testing'. The
company is a ' maker of the world's most
popular concussion evaluation system'
offers a 20 minute computerized test that
players can take via software or online to
measure verbal and visual memory,
processing speed, reaction time and
impulse control. ImPACT dominates the
testing market and has spread to clubs
including NFL, MLB, MLS, NHL, boxing,
hockey, soccer and auto racing circuits.
Known as the 'iPhone of diabetes
care' this Finnish health technology
company develops disruptive
diabetes management solutions
which are designed to significantly
reduce the burden of the conditions
for individuals and healthcare
organizations. The Mendor Discreet
is a blood glucose meter which can
last for up to 1000 tests, hold 250
results and integrates data download
via a USB data-cable. Mentor Balance is the name of the web-based software application
which allows patients to determine possible problem areas in their diabetes treatment.
14.
CAP intiative
Merck's Telehealth
Merck in partnership with Kenya Ministry of
Health, has launched their first telehealth
clinics at both of Kenyatta National Hospital
in Nairobi and Machacos Hospital as a part
of their e-health initiative in Africa. Merck e-
health is a new initiative of Merck’s 5 year
Capacity Advancement Program (CAP)
which was established in 2012. to expand
healthcare capacity in the areas of R&D,
supply-chain integrity and efficiency,
pharmacovigilance, medical education,
and community awareness in Africa
and developing countries. Merck’s
telehealth clinics will allow patients and
healthcare providers in remote areas
through using the power of IP and
video conferencing to interact with
Cancer specialists at Kenyatta
Hospital, the largest national referral
and teaching hospital in Kenya in order
to extend the reach of healthcare into
remote areas.
7. The iKnife is based on electrosurgery,
using an electrical current to rapidly heat
tissue. This cuts through the biomatter
without a lot of blood loss and, uniquely,
the device then sucks this surgical smoke
into a mass spectrometer, which can
indicates whether the cut tissue is
cancerous or healthy. In the first study to
test the invention, by researchers at the
Imperial College London and published in
the journal Science Translational
Medicine, the iKnife diagnosed tissue
samples from 91 patients with 100%
accuracy, instantly providing information
that normally takes up to half an hour to
reveal in the lab.
iKnife NeuroMetrix
The company's Quell device utilizes non-
invasive neurostimulation technology to provide
relied from chronic pain, particularly
neuropathic pain such as from diabetes and
lower back problems. It has been cleared by
the FDA for the treatment of chronic pain
without prescription and users have the option
to use their smartphones to automatically track
& personalize their pain therapy.
15. 16.
17. Med
Sensation
This medical glove prototype is
equipped with sensors, including an
accelerometer, pressure and
temperature modules, and the
researchers hope to apply ultrasound
pads to the fingertips to allow doctors
to peer inside your body whilst
examining you. Longer-term, it is
hoped that these gloves will allow the
public to check for lumps or enlarged
organs at home.
8. Project Soli
Google's Advanced Technology and Projects Group
LifeImage
This Mass-based company runs a huge medical image sharing network (120 multi-site
health systems, 393million images uploads) for diagnostic imaging information between
hospitals, physicians and patients. The network integrates with the Epic and Cerner
electronic health records systems, the clinical systems used by a majority of large medical
groups and hospitals in the US. Currently the lack of medical image sharing, which often
leads to unnecessary, duplicative procedures, is said to cost the US health system
$30billion every year and now LifeImage has just closed a new $17.5 million round of
funding (led by Cambia Health Solutions) to try to solve the problem.
18.
This initiative tracks movements with a
tiny radar to give devices the ability of
recognizing human gestures and then
trigger corresponding responses. The
group proposes that instead of using
tools, we should use our "hand motion
vocabulary" to control devices. The
death of the joystick in robotic surgery I
think.
19.
20. LUMOback
The LUMOback sensor is a wastband
device that vibrates when it senses bad
posture. The sensor connects wirelessly
to a mobile app that tracks your posture
and daily activities in real time.
9. Celleron
Celleron is a biodegradable tissue scafford that is being developed by engineers at Swansea
University in Wales. The biomaterial comes as both a liquid biopolymer and a filament
derivative which can be 3D printed to replicate structures of complex tissues. The research
group leader, Dr Dan Thomas, says that the material is built using phospholipids, graphene,
collagenm antibiotics and agarose, which allow for "independent cell adhesion, cell-to-cell
communication and differentiation".
23andMe
21.
- 3D bioprinting
Thync22.
This Boston device-maker has gained
alot of attention for its wireless wearable
electrode for your brain, which is
designed to tune your mood. The device
comes with two settings, "Calm" or
"Energize" and a recent study (pending
peer review) using 3,000 test subjects
seem to suggest it works. The science
behind it is that when transdermal
electrical neurosignaling (TEN) is
targeted to the ophthalmic and maxillary
divisions of the right trigeminal nerve
and cervical spinal nerve afferents, it
can significant suppress heart rate
variability, galvanic skin responses and
salivary alpha-amylase levels in
response to stress.
23.
Interested in discussing these digital health
innovation? Check out our event website:
www. bigdataleadersforum.com
The FDA has authorized 23andMe to restart its
consumer-focused marketing on health-related
genetic testing for single disease analysis. This is
an "important first step" towards the goal of full
suite of DNA analysis, and using its 'big data' in
the search for new therapeutics, particularly in
patient subgroups.
The company's Chief
Scientific Officer is
recently appointed
Richard Scheller,
winning of the Lasker
Prizer ("America's
Nobel") and so the
Google-backed
personal genetics
company may well
make waves in the
biotech sector.
10. Setpoint Medical
Treating patients with debilitating
inflammatory diseases using proprietary
implantable neuromodulation devices.
The technology is implanted in the vagus
nerve of the neck and when activated
reduces the inflammatory reflex (a
physiological response that control
inflammatio) via a pathway discovered
by the company's cofounder.
Proteus Digital Health
The company is integrating regular pharmaceuticals with ingestible sensors, developing so-
called 'digital medicines' using its Helicus feedback system. The concept is that when
swallowed the sensor communicates drug delivery & physiological parameters - time of
ingestion, heart rate, activity - to a wearable patch which sends information to healthcare
providers and self-management mobile devices. Big Pharma is already looking to develop this
potential with partnerships already existing with Novartis and Otsuka Pharmaceuticals.
Propellor
Health
A GPS-enabled device is attached
to an ordinary inhaler to allow for the
tracking of time and location of each
breath. This information is fed back
to medical professionals and
enables medication compliance to
be assessed plus, on a population
basis, the pinpointing of 'hot spots'
of breating difficulty. Perfect for
monitoring urban pollution levels
and its relationship with public
health.
24.
25.
26.
11. Beurer
The German tech group has
launched its BF700 body analyser
scale (May 2015). This is a quiet
market at the moment but has
huge potential for delivering
useful body composition data. In
addition to claiming an accuracy
down to 0.1% division for body
fat, body water and muscle ratio,
the BF700 has Bluetooth Smart
technology to allow users to track
movements at home and out the
door. The picture on the right is of
course no actually the product in
question.
Lift Lab
27.
28.
The liftware stablizing handle
contains sensors that detect
hand motion and a small
onboard computer that
distinguishes unwanted tremors
from the intended movement of
the hand. To stabilize the
utensil, the computer directs two
motors in the handle to move the
utensil attachment in the
opposite direction of any
detected tremor. Clinical studies
have found that the tech
automatically stabilizes and
shakes 70% less than your
hand.
29.Re-Timer
Developed by an Australian sleep research
company, this frame fits on your own glasses
and uses a soft, green light to regulate your
body's internal clock - ideal for jetlag.
12. HealthKit &
ResearchKit
30.
Apple's Healthkit allows apps that provide health and fitness services to share their data with
the new Health app and with each other other. A user's health information is stored in a
centralized and secure location and the user can decide which data should be shared with
their app. The mobile dashboard shows all the fitness and health data of the user, including
the heart rate, calories burned, blood pressure, blood sugar, cholestoral and other similar
functions. For connected third-party electronic accessories and wearable technologies, the
app allows them to directly monitor and analyze an individual's physiology for medical and
fitness purposes.
The ResearchKit is a digital platform for biomedical research and allows patients to download
apps to search fro enrollment in drug and therapy trials for various conditions. The company
is trying to improve health research by easily allowing anyone to participate in a trial 'from
their couch'.
Big Health31.
The company is aiming to bring highly
personalized behavioural medicine
programs to the masses.
Their first product, Sleepio, is an app that uses
tracked data to create schedules to help
consumers sleep better without the use of
medication. It was validated as the world's first
placebo-controlled RCT for digital sleep
intervention and the company's focus on
behavioural therapies using personal data lends
itself to a range of medical fields, including
mental health and rehabilitation.
Cupris Health32.
AXA PPP Health Tech & You Category Winner,
Cupris Health is turning smartphones into
medical devices with patent-pending
technology. Its proprietary otoscope and
ophthalmoscope devices have various
capabilities which include capturing images,
recording videos from the ear drum, conducting
basic hearing tests and transmitting patient
data. Being UK based, figures have described
that widespread usage of this technology has
capacity to save the NHS £250million a year on
unnecessary ENT referrals.
13. Geneix33.
Geneix analyzes raw data from personal
genetic tests and creates a DrugGene&Me
profile which recognizing certain gene
variations associated with adverse reactions
to prescribed drugs. This information can be
sent and stored with the patient's medical
professional or organization. Analysts have
noted that if the company decides to release
data in consumable reports to patients or sell
data to pharmaceutical companies, the
potential is endless.
FlatIron Health35.
The company was started by Invite Media founders
Nat Turner and Zach Weinberg. The pair sold their
bidding exchange software and advertising
technology company to Google in 2010 for a
reported $80million. Subsequently, they saw the
possibility of disrupting the healthcare space with
data-mining technology and cloud-based software.
When Turner's seven year old cousin was
diagnosed with Leukemia (and is now recovering)
they found problems in the way medical data is
mined for the benefit of oncology patients and the
doctors treating them.
Flatiron Health is now building an "oncology data
platform" to allow cancer care providers to compile,
mine and analyze clinical oncology data.
MediSafe34.
The company is focused on a cloud-based
medication management platform. The
software is designed to understand the
personal causes of non-adherence and uses
this information in real time to create better
patient engagement and raise medication
compliance. Of course the improved health
outcomes for the patient would bring financial
benefits to providers and drug companies.
14. CORNER
Instabeat
A device that mounts to your swimming goggles
to track your heart rate via your temporal artery,
plus calories burnt and number of laps made. As
you would expect it syncs with a personal
dashboard to track progress over time. The
technology won first place at the MIT Enterprise
Forum Pan Arab Business Plan Competition in
2012.
This company builds healthcare
'stations' which allow patients to
interact with board-certified healthcare
providers using high-definition
videoconferencing and a suite of
connected medical devices (including
blood pressure cuffs, otoscope,
stethscope, pulse oximeter) to stream
biomedical information. These
telemedicine kiosks can be placed in
workplaces, retail slots and
pharmacies, and has a strong
company board to support its
development, including Cleveland
Clinic CEO Floyd Loop and Cardinal
Health SVP Christi Pedra.
HealthSpot
@Point of Care
The company positions itself as bridging the gap
between clinician, patient care and data by
providing a platform to improve adherence, patient
outcomes, and engagement between clinician and
patient. The software allows for clinical support at
your 'fingertips', including; real-time reference tool,
journal articles, drug and best practice infromation,
rich content tools featuring multimedia, note-taking,
sharing and highlighting.
36.
37. 38.
JOIN US
in October?
15. Rapid diagnosic dongle
A dongle - a small device that
easily connects to a smartphone
or computer. A team of
researchers at Columbia
Engineering are developing a
low-cost smartphone accessaory
that can perform a point-of-care
test which detects three
infectious disease - HIV and two
variants of syphilis - markers from
a finger prick of blood in 15
minutes. Their pilot work with 96
patients in Rwanda has been
published in the journal Science
Translational Medicine.
iHealthLabs
Last September, iHealth Labs secured
$25million in venture capital from
Xiaomi Ventures, a unit in one of
China's largest smartphone markers,
Xiaomi. The company has established
itself as one of the key leaders in the
connected health device space and its
technology (and accompanying apps)
now track everything from blood
glucose to oxygen saturation, heart rate
to body fat. The company launched its
first wireless blood pressure monitor in
2012, followed by its first wireless
glucose monitor in 2013; all of which are
now sold in Walgreens, Best Buy and
Amazon.
39
40
16. AdhereTech
Omada Health
The company specializes in delivering behavioral medicine that is clinically supported
and evidence-based, with published results in peer-reviewed journals. It's leading
product is 'Prevent' and is based on the landmark Diabetes Prevention Program clinical
trial. It is a 16 week online program that supports individuals in regular exercise and
having a healthy diet. The solution has partnered with integrated delivery networks, like
Kaiser Permanente, and large insurance companies, such as Humana, demonstrating
that its program participants lose on average 5% of their body weight.
Under Armour
The footwear, apparel and
equipment manufacturer is
taking steps to build the world's
largest digital health and
fitness community. The
acquistions of San Francisco-
based MyFitness Pal (tracks
fitness & diet) and Denmark-
based Endomondo (free GPS-
based tracking apps) gives the
company access to over
100million users and it has just
opened a new 'Connected
Fitness' digital headquarters in
Austin, Texas.
41
42
43
Smart wireless pill bottles are
currently being used by patients
in pharmaceutical and research
engagements. Theses bottles
collect and send all adherence
data in real-time. The system
automatically analyzes this
information and populates the
data on our secure dashboard.
17. Medwand44
The device includes an in-ear
thermometer, heart rate sensor,
blood oxygen sensor, camera, digital
stethoscope, and disposable
specula, and it records clinical data
into a HIPAA-compliant electronic
health record (EHR).
RespondWell45
Taking a gameification approach to
rehab, this virtual reality platform uses
Microsoft Kinect to administer programs
on fall prevention, pulmonary and
general fitness. Patients can customize
the trainer (therapist avatar), music and
background.
Augmedix46
Funded by Rock Health, Emergence
Capital Partners, Great Oaks Venture
Capital and Stanford Venture Studio, this
company channels Google Glass to
transcribe patient notes into electronic
health records. The software also allows
doctors to verbally call up a patient's
records or test results. The goal is to
'rehumanize' healthcare by freeing up
more doctor time with patients.
18. BridgeCrest Medical47
This San Diego-based company
specializes in infectious disease tracking
and fatigue management. It gained alot of
attention through its Ebola efforts in 2015,
teaming up with JAJ International to bring
one-step mobile Ebola testing to the
market.
Aside from pandemics, its expertise can
be applied to a number of contagious
diseases including seasonal flu.
Butterfly network
The network was founded by noted biosciences
entrepreneur Jonathan Rothberg and a group of
physicists and engineers from MIT's Lincoln
Laboratories. It has raised $100 million in
funding rounds and is developing a new kind of
medical imaging devices which use artificial
intelligence techniques to analyze a database
worth of images.
48
LEAGUE
49
LEAGUE is trying to rethink the
way we approach care by creating
a data-rich digital health and
wellness platform which gives
people the power to 'take control of
their health'. Members can
discover the best health services
and in time, can build a 'league of
their own' - a team of medical
professionals that work together to
deliver personalized programs.
JOIN US
in October?
See our website:
www.bigdataleadersforum.com
19. 50 Google X?
"Google has embarked on what may be its most ambitious and
difficult science projects ever: a quest inside the human body.
Called Baseline Study, the project will collect anonymous
genetic and molecular information from 175 people-and later
thousands more-to create what the company hopes will be the
fullest picture of what a healthy human being should be."
- The Wall Street Journal
Dr Jessica Mega, Head of Baseline
Study, Google X is speaking in
October, look below at who else will
be there.
Speakers confirmed for October 7-8th in Washington DC
Interested in joining us?Email me at nicholas.longworth@phacilitate.co.uk
Dr Trent Haywood, SVP, Office of Clincial Affairs & Chief Medical Officer, BlueCross BlueShield Association
Dr Harry Leider, Chief Medical Officer, Walgreens
Mark Pitts, VP, Enterprise Informatics, Data & Analytics, Highmark Health
Frank Cunningham, International Policy Officer, CONNECT, European Commission
Dr Jessica Mega, Head of Baseline Study, Google X
Dr Howard Golub, Vice President, Clinical Research, Walgreens
Dr Roy Baynes, SVP, Global Clinical Development, Merck
Bill Pierce, Chief of Platform Solutions, Parexel
Adriana Karaboutis, EVP Technology, CIO, Biogen
Dr Dimitris Agrafiotis, VP & Chief Data Officer, Covance
Gillian Cannon, SVP Commercial Strategy & Customer Insights, Otsuka
Dr Nicholas Marko, Chief Data Officer, Geisinger Health System
Dr John Reynders, Vice President, R&D Informatics, Alexion Pharmaceuticals
Eddie Chan, Head, Search & Evaluation, Sanofi
Dr Omar Dabbous, Head of Quantitative Science Payer Evidence, GSK
Dr Morten Sogaard, VP & Head Enterprise Scientific Technology Operations, Pfizer
Joseph Corkery, Senior Product Manager, Genomics, Google
Dr Charles Barr, Head, Evidence Science & Innovation, Genentech (tbc)
Dr Alan Go, Director, Cardiovascular Research Network, Kaiser Permanente
Leo Barella, VP, Enterprise IT Data Intelligence, BlueCross BlueShield Michigan
Stephen Chick, Market VP, Humana
David Isom, Global Head, R&D Information Strategy and Analytics, Pfizer
