TransMed Systems provides precision medicine software to help clinical trial sponsors and CROs improve patient recruitment. Their platform aggregates clinical and genomic data to identify potentially eligible patients in real-time. This addresses a key challenge of low patient accrual rates. TransMed also operates a network of oncology practices to expand trial outreach. Their goal is to provide a single source of truth on patient data to facilitate collaboration between CROs and healthcare providers.

1. Impacting Human Health
Accelerate Clinical Trial Recruitment
TransMed Systems, Inc.
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Find More Qualified Patients
... Faster
Simplify Site Selection
Increase
Patient Accrual Rates
Win More Studies

2. Impacting Human Health
Discover Apply Improve
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Improving Clinical Trials in Oncology by Enrolling the Best Patients
Sept 21, 2017
TransMed Systems, Inc.
Helping CROs and Pharma Change the Game in Oncology Clinical
Trials Through Knowledge-Empowered Precision Medicine

3. Impacting Human Health
Executive Summary
▪ TransMed Systems (TransMed) is a precision medicine software
company with deep experience in software engineering,
bioinformatics and life sciences
▪ Beginning in 2003, researchers at the Van Andel Research Institute
(VARI) in Grand Rapids, MI, undertook the development of a novel
set of bio-informatics tools with the goal of providing unique insights
into disease based on molecular, preclinical, clinical and therapeutic
data
▪ The core technologies upon which TransMed has been founded were
developed in the Translational Research laboratory of Dr. Craig Webb
at VARI
TransMed Systems, Inc.
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4. Impacting Human Health
Executive Summary
▪ TransMed Systems Inc., was formed in July of 2010, to
commercialize technology developed at the Van Andel Research
Institute
▪ The TransMed team is drawn from the healthcare and software
engineering industries, where the team has more than a hundred
man-years of software development experience building software
applications for commercial use
▪ The TransMed leadership team was among the first two personalized
medicine clinical trials in the nation. Leadership also includes
oncology-specific technology expertise in research and electronic
medical records (OncoEMR™).
TransMed Systems, Inc.
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5. Impacting Human Health
Knowledge-Empowered Precision Medicine
One of the biggest challenges to higher patient
accrual rates and overall clinical trial recruitment
success is the lack of accurate and timely patient
data
TransMed has applied patented data science to
solve this problem of patient data quality and data
fragmentation between CRO clinical trial
recruitment workflows and patient data records at
Provider sites
This new solution utilizes real-world evidence to
finally provide a ‘single source of truth’ for accurate
and timely longitudinal patient data records. We
call this new set of capabilities Knowledge-
Empowered Precision Medicine
TransMed Systems, Inc.
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6. Impacting Human Health
We are a Precision Medicine Software Company
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Our enterprise solutions accelerate the translation of clinical &
genomic data from research into clinical care and clinical
development
TransMed Systems, Inc.
Clinical Care Drug Development IVD Clinical Trials

7. Impacting Human Health
 Integrated genomic and clinical data is required for precision medicine
Opportunity
 Collaboratively, accelerate the formation of multi-institutional disease consortia
Strategy
 Best in class technology for data aggregation, integration, analytics and reporting
Leverage
TransMed’s Rationale & Strategic Intent
TransMed Systems, Inc.
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+ =
Improve patient outcomes

8. Impacting Human Health
We Inform Clinical Decision Making with Personalized
Molecular & Clinical Analytics
TransMed Systems, Inc. Company Confidential 11
Extraction and
Transformation
Structure, Model,
Integrate & Aggregate
Commercial Use in
Precision Medicine
Patient Data
Clinical Decision
Support
Clinical Quality
Management
Clinical Trial
Population
Screening
Clinical Trial Design
Clinical Trial
Site Selection
Translational
Research
Clinical Action Repository
(CARE)
Patients Like Me
Analytics
Member Apps
Industry Apps
Industry Data
Sequence
Analysis
Electronic
Health Record
Precision Medicine
Platform
Data Integration &
Aggregation
Data Science &
Analytics
Vocabulary
Services
Combination
Therapies
Cancer
Episode
Remission /
Recurrence
Clinical Practice
Suite
Clinical Development
Suite
Data Sciences &
Analytics

9. Impacting Human Health
TransMed’s Precision Medicine Platform Readies
Healthcare Data for Commercial Use
TransMed Systems, Inc.
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Data Integration Data Science Data Aggregation
TransMed
Federation Coordinator
N
M
C
C
N
E
C
S
G
H
S
Commercial
Use
Data
Enrichment
Data Integrity
Data
Completeness
Data
Quality Assurance
Data Science
that continuously Learns
TransMed
Stage
Data
TransMed
Golden
Data
TransMed
Stage
Data
TransMed
Golden
Data
TransMed
Stage
Data
TransMed
Golden
Data

10. Impacting Human Health
Accelerating Clinical Trial Recruitment
Successfully enrolling patients in oncology clinical trials has been a historical bottleneck in
the drug development process
TransMed has developed a multi-faceted solution to directly address these challenges
and help CROs win more studies
At the core of the solution is the TransMed Consortium – a technology-enabled clinical
oncology research network that helps clinical trial sponsors and CROs quickly and
efficiently design new trials and accrue patients to their current trials
Complementing the Consortium network is a unique suite of clinical trials support
applications designed to automate the vast majority of the process of matching patients to
trials
TransMed’s knowledge-empowered precision medicine platform has been uniquely
architected to help CROs easily access and understand both real-time patient data and
de-identified population data in support of complex clinical trial feasibility, planning and
execution processes
TransMed Systems, Inc.
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11. Impacting Human Health
Accelerating Clinical Trial Recruitment
This platform is capable of ingesting data from most electronic medical records
(EMR) systems, practice management systems, lab information systems,
molecular diagnostics results systems, cancer registries and bio-banks
TransMed’s patented data science allows TransMed data scientists to identify
anomalies in the ingested data sets as they compare to national reference data.
Inferences can be made and notated as derived data points that assist in
visualizing an entire health encounter for a given patient or an entire population.
This highly-specialized data set is ideal to screen for matches for potentially
eligible patients for clinical trials, based on inclusion and exclusion criteria
Most importantly, the TransMed platform serves as a single source of truth that
presents real-world evidence to help CROs and Providers collaborate to
facilitate patient identification, screening, consent and retention. The result –
more successful clinical trial recruitment
TransMed Systems, Inc.
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12. Impacting Human Health
The Power of a Health-Data Unifying Platform
Knowledge-Empowered Users Collaborating
from a Federated Repository of Longitudinal Patient Records
Clinical / Practice
Views
Pharma / CRO / Payor
Views
Both Identified Patient Data,
And Identified Population Data
Only De-identified
Population Data
Federated Repository
Of Longitudinal
Patient Data Records
Physicians, PA / NP,
Research Director,
CRC
Pharma R&D,
Trial Feasibility Designers,
Site Management Analysts

13. Impacting Human Health
Single Source of Truth
TransMed Systems, Inc. Company Confidential
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14. Impacting Human Health
TransMed’s Differentiation
TransMed Systems, Inc. Company Confidential
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Competitive Advantage
Data
Quality
Secure
Scalable
Time to
Value
Total Cost
Ownership
Innovation
Federated Aggregation
Architecture
Data Integration
Data Science
Multi-Stakeholder
Value

15. Impacting Human Health
Knowledge-Empowered
Precision Medicine Capabilities
TransMed Systems, Inc. Company Confidential
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▪ Disruptive technology changing the way
clinical trials are executed
▪ Deliver real-world evidence to users, in
real-time, by providing a single-source-of-
truth about eligible and available patients
▪ A robust and growing community oncology
practice network to expand CRO outreach
▪ Superior data quality and completeness
through NLP-based data science and
enrichment techniques
▪ A suite of stakeholder-aligned apps to
facilitate collaboration between CROs
and Providers
▪ Real-time data federation provides timely
updates to patient and population data
▪ Support for finding the right sites and
accelerating site selection
▪ Dynamically assess protocol feasibility

16. Impacting Human Health
Scientific Advisory Board
Paul A. Bunn, Jr, M.D
Distinguished Professor
Division of Medical Oncology
University of Colorado
James Dudley Chair in Lung Cancer Research
Daniel Von Hoff, M.D.,
F.A.C.P.
Chief Scientific Officer VGPCC Clinical
Trials Program at Scottsdale Healthcare
Physician in Chief, Tgen
Professor of Medicine, Mayo Clinic,
Clinical & University of Arizona College of
Medicine
Stanley R. Hamilton, M.D.
Division Head, Pathology/Lab
Medicine
The University of Texas MD Anderson
Cancer Center
Noah M. Hahn, M.D.
Associate Professor of Medicine
Department of Oncology and
Urology
Johns Hopkins University School of
Medicine
W. Jeff Edenfield, M.D.
Greenville Health System
Institute for Translational Oncology
Research
Barbara McAneny, M.D.
CEO, New Mexico Cancer Center
CEO, Innovative Oncology Business
Solutions
AMA President 2017
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Medicine Software
Innovation
Innovation happens
at the intersection of two disciplines

17. Impacting Human Health
Company Background
▪ The engineering talent at TransMed Systems has been building
novel, innovative technology together since the late 1990s
▪ As market benders, the TransMed team sold their previous company,
Rational Software to IBM for $2 Billion
▪ The opportunity to change the life of each cancer patient attracted
this group to stay together and build a new infrastructure technology
that compiles relevant information about each cancer patient with the
goal of finding a clinical trial to match the patient’s disease
▪ Early usage of the TransMed precision medicine software platform
has resulted in 18 publications in 17 peer reviewed journals including
New England Journal of Medicine, Journal of Translational Medicine
and Nature Medicine, where the platform was deployed to support
various studies
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18. Impacting Human Health
Company Background
▪ The most recent version of the platform was chosen to support
neuroblastoma research of the fifteen institutions in the
Neuroblastoma and Medulloblastoma Translation Research
Consortium (NMTRC). The NMTRC will utilize the current TransMed
platform for a number of molecularly focused studies funded by a
grant from the Dell Foundation
▪ In addition, our platform was selected as the Personalized Medicine
platform to support the Stand Up 2 Cancer Melanoma Dream Team
Study by its Principal Investigators Drs. Jeff Trent, and Patricia
LoRusso
▪ TransMed’s Bio-informatics Suite of tools has been deployed at a
number of major hospitals supporting Research and Clinical Decision
Support, including Moffitt Cancer Center and Lurie Children’s
Hospital of Chicago, where it is in use supporting over 50 different
clinician-driven projects
TransMed Systems, Inc.
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19. Impacting Human Health
Meet us at Site Solutions Summit
TransMed Systems, Inc.
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Meet With Us At The Site Solutions Summit!
We’re attending the 2017 SiteSolutions Summit Conference
in Boca Raton, FL on October 5-8. Please contact RafaelCasiano
at rcasiano@xbtransmed.com to setup a meeting
and view the software tool demo.
© 2017, TransMed Systems, Inc. www.xbtransmed.com

20. Impacting Human Health
Contact Information
TransMed Systems, Inc. Company Confidential
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Rafael Casiano
Vice President
Sales & Business Development
TransMed
O: 813-330-7555
C: 813-944-8379
rcasiano@xbtransmed.com
www.xbtransmed.com
www.linkedin.com/in/rafael-casiano-83b62222