Deep Tech Startups vs Covid-19
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While many companies are contributing to the battle against the pandemic, Deep Tech startups are trying to overcome scientific challenges to help with prevention, testing or treatment in novel and scalable ways. This live event organized by SOSV brings together investors who have backed dozens of relevant startups, to get a sense of: - The variety of solutions being developed, - Their potential outcomes, - The broader role and opportunities of deep tech investment. SPEAKERS - Seth Bannon, Founding Partner, Fifty Years - Jun Axup, PhD, Chief Science Officer & Partner, IndieBio / SOSV - Alex Morgan, MD PhD, Partner, Khosla Ventures MODERATORS - Julie Wolf, PhD, Communications Director, IndieBio / SOSV - Benjamin Joffe, Partner, SOSV COVID-19 PORTFOLIO - Fifty Years: www.fifty.vc/covid - SOSV: www.sosv.com/covid-startups/ - Khosla Ventures: www.khoslaventures.com/khosla-ventures-entrepreneurs-are-responding-with-amazing-diversity-to-covid-19-solutions-for-societys-needs
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Deep Tech Startups vs Covid-19
- 1. www.sosv.com DEEP TECH STARTUPS vs. COVID-19LIVE
- 6. Investing At Scale #2 Most Active Global Seed Fund in 2019 Crunchbase, 2020.01 150 Startups / Year $100k-$250k Looking Glass Factory 3D Holographic Display Follow-on Up to $1.5m / round Flow Neuroscience Depression Treatment Memphis Meats Cultured meat Investing At The Edge • Early stage deep tech fund • $700m AUM, 1000 startups • 150 startups/year • Leading accelerator programs Life Sciences (Indiebio) Hardware (HAX) Food (Food-X) Asia cross-border (Chinaccelerator & MOX) Simbe Robotics Shelf auditing and analytics Deep Tech Early Stage $277m Fund size $700m+ AUM
- 7. Low-cost genetic tests Sensors & robots Cloud solutions COVID-19 vs SARS 2003
- 13. 3d-printed swabs 200+ can be made in a single print 3D Printing Parts Formlabs
- 14. Formlabs Support Network 3,000+ volunteers with over 5,000 printers
- 15. Nanofiber Mask Verdex • More breathable new material that blocks the virus (diameter ~120nm). • Effective from 100nm (vs. 300nm+ for N95)
- 16. • Hands can lead to contamination via face touching. • Keen uses ML to recognize specific movements and raise awareness. Reduce Face Touching Keen Smart Bracelet
- 17. • Avidbots created autonomous cleaning and polishing robots that can include disinfectants. • They have been deployed globally in airports, hospitals, etc. Floor Disinfection Avidbots
- 18. • TV and movie productions will need regular disinfection to #OpenSafely • On-site dry cleaning robot. Press / dry / disinfect in < 5min • Robots will save Hollywood! Clothing Disinfection Presso
- 19. Bathrooms Somatic • Autonomous cleaning robot • Starting with bathrooms
- 20. • UVC lamps for disinfection. • IR sensors and cameras for temperature scanning. Area Disinfection Youibot
- 21. • 3D mapping and autonomous for precision disinfection with UVC. • Targets high-touch areas. Precision Disinfection Rovenso
- 23. • Smart helmets* with IR sensors and AI-based face recognition. • Range of 5m, alert if >37.3C. • 2 minutes to scan 100 people Smart Helmet For Fever Scanning * Made by Kuang-Chi Used in Chengdu & Shenzhen.
- 27. • Tracks temperature, sleep, activity and HRV. • Early tests show the AI model can currently predict a case 24h in advance 90% of the time. Smart Ring for Pre- Symptom Detection Oura Health
- 28. Breathing Monitoring Strados Labs • Remote E-Stethoscope Platform for enhanced telehealth.
- 31. Manufacturing Capacity Building “If anything kills over 10 million people in the next few decades, it’s more likely to be an infectious virus, rather than a war. […] We’re not ready for the next epidemic.” Bill Gates, TED 2015 • The Coalition for Epidemic Preparedness Innovations (CEPI) invested in 8 vaccine programs. • The Bill & Melinda Gates Foundation is spending billions to build factories for the 7 most promising vaccine candidates.
- 32. • Repurposing existing drugs could have a faster GTM. • Pharma and startups are racing. New Drugs vs. Old Drugs David Ho Columbia University, USA
- 34. • Mods of BIPAP / CPAP machines. • Open Source project by UC Berkeley engineers, ER doctors and critical care pulmonologists. • Could free up some ventilators. From Sleep Apnea To Ventilators? Source: VentilatorSOS.com
- 35. • Higher safety and comfort • Protects the environment from an infected patient. Single Patient Isolation & Transport System EpiShuttle
- 36. Emotions Monitor Sentio Solutions • Feel bracelet is an Emotion Sensor and Cognitive Behavioral Therapy (CBT) • Quantify a person’s emotional state, and deliver 24/7 emotional health support.
- 39. Ventures in the time of COVID-19 Alexander A. Morgan, MD PhD @genomicsdoc May 2020
- 40. Reinventing Social Infrastructure with Technology https://medium.com/@vkhosla/reinventing-societal-infrastructure-with-technology-f71e0d4f2355
- 41. 3 Societal Impact Financial Returns Totemic VC India Impact ck12 Breakthrough Energy Khosla Impact Giving Pledge Aadhar Bridge
- 42. Khosla Ventures’ Portfolio Response to COVID-19 “Khosla Ventures’ entrepreneurs are responding with amazing diversity to COVID-19 solutions for society’s needs!” https://medium.com/@vkhosla/khosla-ventures-entrepreneurs-are-responding-with-amazing-diversity-to-covid-19-solutions-for-47a4c8d447ac
- 43. Unique silicon photonics diagnostics technology, FDA approved Can deliver results in < 15 minutes, wide range of analytes COVID-19 serology testing developed: IgG & IgM, 12 unique antigens Capacity ~250K/patients a month, ramping up to 7.5M/month by fall Working in collaboration with Collective Health on their Collective Go back to work program 5
- 44. Proprietary nanoparticle technology for pathogen detection using mobile phone Demonstrated in clinical trial for Chlamydia Significant advantages in sensitivity and specificity over colorimetric lateral flow, with better quantification Developing point of care IgG & IgM serology testing 6
- 45. Coronavirus protease inhibitor chemistry 7 Pardes Bio Uri Lopatin, MD YC Biotech Partner Prior Co-Founder/CMO of Assembly Biosciences (Hep B virus therapeutics) Lee Arnold, PhD Prior CSO of Assembly Biosciences
- 46. Tissue and organoid engineering company Creates 3D scaffolds to support tissue architecture Tumor xenograft vascularization/micro-environment Large vessels, kidney nephrons, liver lobules, lung lobes Ex vivo lymph nodes to produce therapeutic antibodies May 19, 2020: Announced 300 different human antibodies against S1 or S2 spike protein from 960 Externalized Human Immune System lymph nodes 8 PRELLIS BIOLOGICS
- 47. 9 Distribution of care models changing Mental/behavioral health through telemedicine, available 24-7 Personalized care for every member Prescription writing for antidepressants up 86% Transcranial electric stimulation for anxiety and depression at home CE Mark approval for sale in Europe/UK
- 48. Submit Pitch Materials: kv@khoslaventures.com Bold, early, impactful … calling all entrepreneurs! We have made several new investments since shelter in place.
- 50. COVID-19 Startups May 28, 2020
- 51. 136companies $2.3B 5years SF & NY 36countries 43% enterprise value co’s with female co-founders
- 52. CASPR Biotech: Point of care SARS-CoV-2 CRISPR Dx
- 53. Renegade.bio: Lab testing without RNA extraction
- 54. ANA Therapeutics: Niclosamide; a SARS-CoV-2 Replication Inhibitor
- 55. 3D Printed lymph nodes for rapid development of COVID-19 antibodies Prellis Biologics:
- 56. Halomine: Powers chlorine-based sanitizers to work for 30 days rather than 1 hour.
- 57. Early detection tracking within nursing homes SmartSteward
- 58. PreventionDetection Treatment Other Active Alumni 42+ SOSV Companies https://sosv.com/covid-startups/
- 59. Biotech is stronger than ever but many unknowns … - Earlier stage investors should be more active - Impact vs returns? Both? - Are pandemics an ongoing investable thesis? - Technology impact on society, politics, equality - Reminder to keep evolving, staying nimble 25M 12.5M