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THE IMPACT OF CBT ON 

DEPRESSION AND ANXIETY IN

BREAST CANCER
PATIENTS
BREAST CANCER
BACKGROUND INFO
50%

Breast cancer patients who experience depression, 

anxiety, or both within the first year of diagnosis.
The number of women currently living who have 

had (or currently have) a diagnosis of breast cancer.

2,747,459
1 in 8 women will receive a breast cancer 

diagnosis during their life.
CBT INFO
BACKGROUND
COGNITIVE BEHAVIORAL THERAPY
An efficacious treatment that can be highly individualized and comes in many
different forms. Psychotherapy involves addressing maladaptive behaviors as well
as their corresponding thoughts. The focus is on the behavioral as well as the
cognitive component in order to better understand how the disease is impacting
the patient.
COGNITIVE BEHAVIORAL THERAPY
has been used in nearly every area of mental health as well as some medical
conditions outside of mental health.
RATIONALE
1

Because CBT can be custom built for
an individual patient and allows room
for the therapist to use good clinical
judgment in order to treat the patient, 

it seems to be an ideal treatment
option for complex diseases that may
not always have the same prognosis 

for each patient.
2

Breast cancer, depending on size 

of the tumor, stage, current and
previous medical and psychological
conditions, age, overall health, social
support, and numerous other factors,
seems to be a prime example of 

a complex medical condition.
3

Evidence has been provided that
CBT alleviates distress and pain 

in breast cancer patients.
4

Many patients with breast cancer
develop mental health issues as a
result of their diagnosis and condition,
especially depression and anxiety.
CBT has been shown to be effective
in treating depression and anxiety.
QUESTIONS
How do other treatment options 

factor in?
What specific components of CBT 

make it ideal?
What about other psychological 

side effects and how to deal with
those?
HYPOTHESIS
CBT will have a significant decrease 

in depression and anxiety in breast
cancer patients.
The CBT group will be superior 

to the care-as-usual (CAU) treatment
group in terms of decreased depression 

and anxiety symptoms.
CAU-SPECIFIC 

QUESTIONS
What does CAU typically entail?
Does CAU differ depending on setting?
METHOD
SETTING
TIME
SAMPLE

Clinic + Hospital
Baseline, 3 months, 6 months and 12 months
18-55 years old; cut off at 55 to control for any
potential cognitive decline

RECRUITMENT Through local oncologist
CBT SESSIONS

1-hour psycho-education session begins with family
members; 1-hour session twice weekly for 8 weeks
DESIGN
This will be a clinical trial as there will
be two groups – one receiving treatment
and one not receiving treatment. At the
end of the project, the two groups will
be compared for differences.
GROUP 1


GROUP 2


This group will consist 

of breast care patients
that will be the “control”
group. They will receive
care as usual from their
oncologist and other
health care providers, 

but not CBT.

This group will receive 

the CBT treatment
previously outlined 

as well as CAU.

CAU

CBT
RANDOMIZATION 

Patients will be randomly divided into either group
by age and number of times receiving diagnosis 

as well as prognosis/stage of cancer.
INCLUSION CRITERIA
A diagnosis of breast cancer within the past year; cannot
be deemed immediately terminal.
EXCLUSION CRITERIA
No other imminent medical or psychological conditions such
as a severe mental illness of chronic condition such as MS,
Lupus, etc. This is to control for internal validity as the other
conditions could be the driving force behind the depression
and/or anxiety.
OTHER
QUESTIONS
What about current medications, such
as SSRIs?
What about the role of support systems?
How does the role of coping strategies
impact outcome?
MEASURES
BDI (Beck Depression Inventory) to assess 

for depressive symptoms.
!

BAI (Beck Anxiety Inventory) to assess 

for anxiety symptoms.
!

Both easy to administer and well-validated 

in clinical settings.
Initial unstructured interviews by a trained and
licensed psychologist will also be administered 

to ensure no underlying psychopathology.
!

An initial medical exam by a physician will also

be conducted.
!

A mixed-model (2 x 3) ANOVA will be conducted.

2 groups: CBT, CAU
3 assessment points: 3, 6, 12 months
Q&A
THANK YOU.
Breast Cancer Study

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Breast Cancer Study

  • 1. THE IMPACT OF CBT ON 
 DEPRESSION AND ANXIETY IN BREAST CANCER PATIENTS
  • 3. 50% Breast cancer patients who experience depression, 
 anxiety, or both within the first year of diagnosis.
  • 4. The number of women currently living who have 
 had (or currently have) a diagnosis of breast cancer. 2,747,459
  • 5. 1 in 8 women will receive a breast cancer 
 diagnosis during their life.
  • 7. COGNITIVE BEHAVIORAL THERAPY An efficacious treatment that can be highly individualized and comes in many different forms. Psychotherapy involves addressing maladaptive behaviors as well as their corresponding thoughts. The focus is on the behavioral as well as the cognitive component in order to better understand how the disease is impacting the patient.
  • 8. COGNITIVE BEHAVIORAL THERAPY has been used in nearly every area of mental health as well as some medical conditions outside of mental health.
  • 10. 1 Because CBT can be custom built for an individual patient and allows room for the therapist to use good clinical judgment in order to treat the patient, 
 it seems to be an ideal treatment option for complex diseases that may not always have the same prognosis 
 for each patient.
  • 11. 2 Breast cancer, depending on size 
 of the tumor, stage, current and previous medical and psychological conditions, age, overall health, social support, and numerous other factors, seems to be a prime example of 
 a complex medical condition.
  • 12. 3 Evidence has been provided that CBT alleviates distress and pain 
 in breast cancer patients.
  • 13. 4 Many patients with breast cancer develop mental health issues as a result of their diagnosis and condition, especially depression and anxiety. CBT has been shown to be effective in treating depression and anxiety.
  • 15. How do other treatment options 
 factor in? What specific components of CBT 
 make it ideal? What about other psychological 
 side effects and how to deal with those?
  • 17. CBT will have a significant decrease 
 in depression and anxiety in breast cancer patients. The CBT group will be superior 
 to the care-as-usual (CAU) treatment group in terms of decreased depression 
 and anxiety symptoms.
  • 18. CAU-SPECIFIC 
 QUESTIONS What does CAU typically entail? Does CAU differ depending on setting?
  • 20. SETTING TIME SAMPLE Clinic + Hospital Baseline, 3 months, 6 months and 12 months 18-55 years old; cut off at 55 to control for any potential cognitive decline RECRUITMENT Through local oncologist CBT SESSIONS 1-hour psycho-education session begins with family members; 1-hour session twice weekly for 8 weeks
  • 22. This will be a clinical trial as there will be two groups – one receiving treatment and one not receiving treatment. At the end of the project, the two groups will be compared for differences.
  • 23. GROUP 1
 GROUP 2
 This group will consist 
 of breast care patients that will be the “control” group. They will receive care as usual from their oncologist and other health care providers, 
 but not CBT. This group will receive 
 the CBT treatment previously outlined 
 as well as CAU. CAU CBT
  • 24. RANDOMIZATION 
 Patients will be randomly divided into either group by age and number of times receiving diagnosis 
 as well as prognosis/stage of cancer.
  • 25. INCLUSION CRITERIA A diagnosis of breast cancer within the past year; cannot be deemed immediately terminal.
  • 26. EXCLUSION CRITERIA No other imminent medical or psychological conditions such as a severe mental illness of chronic condition such as MS, Lupus, etc. This is to control for internal validity as the other conditions could be the driving force behind the depression and/or anxiety.
  • 28. What about current medications, such as SSRIs? What about the role of support systems? How does the role of coping strategies impact outcome?
  • 30. BDI (Beck Depression Inventory) to assess 
 for depressive symptoms. ! BAI (Beck Anxiety Inventory) to assess 
 for anxiety symptoms. ! Both easy to administer and well-validated 
 in clinical settings.
  • 31. Initial unstructured interviews by a trained and licensed psychologist will also be administered 
 to ensure no underlying psychopathology. ! An initial medical exam by a physician will also
 be conducted. ! A mixed-model (2 x 3) ANOVA will be conducted.
 2 groups: CBT, CAU 3 assessment points: 3, 6, 12 months
  • 32. Q&A