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Bank of America Merrill Lynch
  Health Care Conference
          Doug Manion
        Senior Vice President,
  Virology, Neuroscience and Japan
            May 17, 2012



                                     1
Forward-Looking Information
 During this meeting, we will make statements about the
 Company’s future plans and prospects that constitute forward-
 looking statements for purposes of the safe harbor provisions
 under the Private Securities Litigation Reform Act of 1995.
 Actual results may differ materially from those indicated as a
 result of various important factors, including those discussed
 in the company’s most recent annual report on Form 10-K and
 reports on Form 10-Q and Form 8-K. These documents are
 available from the SEC, the Bristol-Myers Squibb website or
 from Bristol-Myers Squibb Investor Relations.

 In addition, any forward-looking statements represent our
 estimates only as of today and should not be relied upon as
 representing our estimates as of any subsequent date. While
 we may elect to update forward-looking statements at some
 point in the future, we specifically disclaim any obligation to do
 so, even if our estimates change.

                     NOT FOR PRODUCT PROMOTIONAL USE                  2
Data as of December 31, 2011


   NME Development Portfolio
                      Exploratory Development *                                      Full                      Marketed Product
                                                                                Development ^                   Development †
  EGFR/IGFR                                                  NS5A Second
Tandem Adnectin         PEG-FGF21       LXR Modulators        Generation              Brivanib              YERVOYTM           NULOJIX ®

 Pegdinetanib             11βHSD                              NS5B Site 1
(VEGF R-2 Adnectin)
                                        PCSK9 Adnectin         Inhibitor                                    SPRYCEL®           ELIQUISTM **
                         Inhibitors                                                Necitumumab
                                           CCR2 / 5           α-7 Nicotinic
Anti-CD70 ADC          TGR5 Agonist       Antagonists           Agonist                                     ERBITUX®          BARACLUDE®
                                                                                     Elotuzumab
 JAK2 Inhibitor         FGF21-PKE       IKACh Inhibitors     Aβ Modulator
                                                                                                            IXEMPRA®           REYATAZ®
                         Adnectin
                                                            Triple Reuptake
    IGF-1R
                                        IKur Antagonists       Inhibitors
                                                                                   Dapagliflozin                               SUSTIVA® /
   Antagonist         GPR119 Agonists                                                                       ORENCIA®           ATRIPLA®
                                                              Microtubule
                           CCR1          Peginterferon                                                    ONGLYZA ® /
SMO Antagonist                                                 Stabilizer            Daclatasvir                                ABILIFY®
                        Antagonists       lambda-1a                                 (NS5A Inhibitor)    KOMBIGLYZETM XR
                                                              Avagacestat
                                          Asunaprevir        (Gamma Secretase
      IL-21              Anti-IP10        (NS3 Inhibitor)        Inhibitor)


    Anti-KIR                             NS5B Inhibitor     GABA/Nicotinic
                         Anti-CD28                            Modulator

   Urelumab                             HIV Attachment
                          Anti-IL6         Inhibitor        CGRP Antagonist
   (Anti-CD137)


Notch Inhibitors       IL-23 Adnectin     Anti-PD-L1


    Anti-PD1             Anti-IL31       NRT Inhibitor

                                         HIV Maturation
  Anti-CXCR4            Anti-CD40L          Inhibitor
                                                              * Post discovery through Phase II
                                        NS5B Primer Grip      ^ Registrational program
   Anti-LAG3          LPA1 Antagonist      Inhibitor
                                                              † Approved in at least one major market

    ONC        MET      IMM      CV     VIR       NS          **ELIQUIS is approved for VTE Prevention in the EU

                                                     NOT FOR PRODUCT PROMOTIONAL USE                                                          3
HCV – Area of High Unmet Need

Historic Standard of   Current Standard of                  BMS Goal
        Care                  Care
  (<50% Cure Rates)      (<80% Cure Rates)
                                                       Higher Cure Rates
                                                           Through:
                           PEG-IFN-α
    PEG-IFN-α                   +                      • Improved efficacy
        +                   Ribavirin
     Ribavirin                  +                      • Improved safety /
                           1st Wave PI                   tolerability
                                                       • Reduced duration of
                                                         treatment




                         NOT FOR PRODUCT PROMOTIONAL USE
BMS Well Positioned With Broad HCV Portfolio
   Daclatasvir (DAC): Potential 1st in class, differentiated NS5A
    Inhibitor in Ph III

   -189: Potent, pan-genotypic Nuc through acquisition of Inhibitex

   Asunaprevir (ASV): Protease Inhibitor in Ph III combo with DAC

   NS5B non-Nuc (BMS-791325) in development in combo with DAC
    and ASV

   Peg-IFN Lambda in development for HCV and HBV

   Strategic partnerships to complement our internal portfolio




                       NOT FOR PRODUCT PROMOTIONAL USE                 5
Daclatasvir Phase III Program
   DAC+ ASV (Dual) in GT1b patients in Japan
     – Enrollment complete, expect trial completion in 2013
     – ~ 2M HCV patients in Japan with about 70% GT1b

   DAC + ASV (Dual) in US and EU
     – GT1b – naives, alfa ineligible / intolerants, alfa null / partials
     – Expected to initiate in 2012

   DAC + ASV + P/R (Quad) in US and EU
     – GT1 null responders
     – Expected to initiate in 2012

   DAC + P/R in co-infected and minority populations
     – Studies ongoing


                      NOT FOR PRODUCT PROMOTIONAL USE                       6
-189: A Key Component of Our HCV Portfolio
   Confident in having dose that provides sufficient viral suppression
    and resistance coverage with acceptable safety and tolerability

   Development Plan
     – Ph II -189 + DAC +/- RBV – Expected to start in 2012, Ph III in 2013
     – Ph II -189 + P/R in GT2/3 – Ongoing
         •   Plan to expand to include combinations of 189, DAC and RBV

   -189 is a potent, pan-genotypic Nuc
     – 7 day study in GT1 patients
         •   >4 log drop in viral load at 200mg QD
         •   Close to 4 log drop at 100mg QD + RBV



                          NOT FOR PRODUCT PROMOTIONAL USE                     7
BofA
  Health Care Conference
         Doug Manion
Senior Vice President, Development
 Virology, Neuroscience and Japan
            May 17, 2012



                                     8

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Bristol-Myers Squibb at Bank of America Merrill Lynch Health Care Conference

  • 1. Bank of America Merrill Lynch Health Care Conference Doug Manion Senior Vice President, Virology, Neuroscience and Japan May 17, 2012 1
  • 2. Forward-Looking Information During this meeting, we will make statements about the Company’s future plans and prospects that constitute forward- looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated as a result of various important factors, including those discussed in the company’s most recent annual report on Form 10-K and reports on Form 10-Q and Form 8-K. These documents are available from the SEC, the Bristol-Myers Squibb website or from Bristol-Myers Squibb Investor Relations. In addition, any forward-looking statements represent our estimates only as of today and should not be relied upon as representing our estimates as of any subsequent date. While we may elect to update forward-looking statements at some point in the future, we specifically disclaim any obligation to do so, even if our estimates change. NOT FOR PRODUCT PROMOTIONAL USE 2
  • 3. Data as of December 31, 2011 NME Development Portfolio Exploratory Development * Full Marketed Product Development ^ Development † EGFR/IGFR NS5A Second Tandem Adnectin PEG-FGF21 LXR Modulators Generation Brivanib YERVOYTM NULOJIX ® Pegdinetanib 11βHSD NS5B Site 1 (VEGF R-2 Adnectin) PCSK9 Adnectin Inhibitor SPRYCEL® ELIQUISTM ** Inhibitors Necitumumab CCR2 / 5 α-7 Nicotinic Anti-CD70 ADC TGR5 Agonist Antagonists Agonist ERBITUX® BARACLUDE® Elotuzumab JAK2 Inhibitor FGF21-PKE IKACh Inhibitors Aβ Modulator IXEMPRA® REYATAZ® Adnectin Triple Reuptake IGF-1R IKur Antagonists Inhibitors Dapagliflozin SUSTIVA® / Antagonist GPR119 Agonists ORENCIA® ATRIPLA® Microtubule CCR1 Peginterferon ONGLYZA ® / SMO Antagonist Stabilizer Daclatasvir ABILIFY® Antagonists lambda-1a (NS5A Inhibitor) KOMBIGLYZETM XR Avagacestat Asunaprevir (Gamma Secretase IL-21 Anti-IP10 (NS3 Inhibitor) Inhibitor) Anti-KIR NS5B Inhibitor GABA/Nicotinic Anti-CD28 Modulator Urelumab HIV Attachment Anti-IL6 Inhibitor CGRP Antagonist (Anti-CD137) Notch Inhibitors IL-23 Adnectin Anti-PD-L1 Anti-PD1 Anti-IL31 NRT Inhibitor HIV Maturation Anti-CXCR4 Anti-CD40L Inhibitor * Post discovery through Phase II NS5B Primer Grip ^ Registrational program Anti-LAG3 LPA1 Antagonist Inhibitor † Approved in at least one major market ONC MET IMM CV VIR NS **ELIQUIS is approved for VTE Prevention in the EU NOT FOR PRODUCT PROMOTIONAL USE 3
  • 4. HCV – Area of High Unmet Need Historic Standard of Current Standard of BMS Goal Care Care (<50% Cure Rates) (<80% Cure Rates) Higher Cure Rates Through: PEG-IFN-α PEG-IFN-α + • Improved efficacy + Ribavirin Ribavirin + • Improved safety / 1st Wave PI tolerability • Reduced duration of treatment NOT FOR PRODUCT PROMOTIONAL USE
  • 5. BMS Well Positioned With Broad HCV Portfolio  Daclatasvir (DAC): Potential 1st in class, differentiated NS5A Inhibitor in Ph III  -189: Potent, pan-genotypic Nuc through acquisition of Inhibitex  Asunaprevir (ASV): Protease Inhibitor in Ph III combo with DAC  NS5B non-Nuc (BMS-791325) in development in combo with DAC and ASV  Peg-IFN Lambda in development for HCV and HBV  Strategic partnerships to complement our internal portfolio NOT FOR PRODUCT PROMOTIONAL USE 5
  • 6. Daclatasvir Phase III Program  DAC+ ASV (Dual) in GT1b patients in Japan – Enrollment complete, expect trial completion in 2013 – ~ 2M HCV patients in Japan with about 70% GT1b  DAC + ASV (Dual) in US and EU – GT1b – naives, alfa ineligible / intolerants, alfa null / partials – Expected to initiate in 2012  DAC + ASV + P/R (Quad) in US and EU – GT1 null responders – Expected to initiate in 2012  DAC + P/R in co-infected and minority populations – Studies ongoing NOT FOR PRODUCT PROMOTIONAL USE 6
  • 7. -189: A Key Component of Our HCV Portfolio  Confident in having dose that provides sufficient viral suppression and resistance coverage with acceptable safety and tolerability  Development Plan – Ph II -189 + DAC +/- RBV – Expected to start in 2012, Ph III in 2013 – Ph II -189 + P/R in GT2/3 – Ongoing • Plan to expand to include combinations of 189, DAC and RBV  -189 is a potent, pan-genotypic Nuc – 7 day study in GT1 patients • >4 log drop in viral load at 200mg QD • Close to 4 log drop at 100mg QD + RBV NOT FOR PRODUCT PROMOTIONAL USE 7
  • 8. BofA Health Care Conference Doug Manion Senior Vice President, Development Virology, Neuroscience and Japan May 17, 2012 8