Number of confirmed cases of Middle East respiratory syndrome coronavirus infection (including those that were travel-associated) reported by the World Health Organization as of 25 February 2015, by month and year of illness onset—worldwide, 2012–2015 [2].
怎麼感染到人身上的呢?在家畜身上的血清學研究發現 Goats, cows, sheep, water buffalo, swine and wild birds were tested negative for antibodies to MERS-CoV
但廣泛存在於駱駝血清中,且其中的傳播至少20年以上。另一個證據是從中東當地單峰駱駝可分離出MERS-CoV,其基因序列與自確診個案檢體分離出之病毒基因序列高度相似;故認為駱駝為人類感染MERS-CoV之潛在感染源,但傳染途徑仍不明(呼吸道分泌物或駱駝奶)
全球首例MERS-CoV病例分離之病毒序列與自埃及單峰駱駝分離之病毒序列,具高度相似,另埃及單峰駱駝屠宰場中,駱駝樣本血清檢體逾九成呈MERS-CoV或近似MERS-CoV抗體陽性,惟其屠宰場工作人員之血清學檢測均呈陰性,顯示MERS-CoV從駱駝傳染給人類之可能性偏低
http://www.who.int/csr/disease/coronavirus_infections/case_definition/en/
不論有無臨床症狀
the key change in this 14 July 2014 update
A case can be confirmed by the demonstration of sero-conversion in 2 samples ideally taken at least 14 days apart, by a screening (ELISA, IFA) and a neutralization assay
http://www.who.int/csr/disease/coronavirus_infections/case_definition/en/
不論有無臨床症狀
the key change in this 14 July 2014 update
A case can be confirmed by the demonstration of sero-conversion in 2 samples ideally taken at least 14 days apart, by a screening (ELISA, IFA) and a neutralization assay
SARS 抗病毒藥/人體外的試驗為主
Ribavirin+INF 14日的存活有benefit; but no 28日存活的benefit