The document discusses how life sciences companies are facing changes in their industry that require a new emphasis on cost management to fuel growth and profitability. Specifically, it notes that traditional high drug prices may not be sustainable given increases in pricing transparency, savvier customers, and government scrutiny. It then recommends that companies obtain a clear understanding of spending, strategically reduce costs using a zero-based approach, and redistribute savings to strategic growth priorities. This could result in a typical 2% reduction in spending and $5 billion in cost savings for the top 50 life sciences companies overall.