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Kawasaki disease
1. Prof. Dr. Saad S Al Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospital, Sharjah, UAE [email_address] Kawasaki disease
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8. Pathogenesis Severe vasculitis Edema of endothelial and smooth muscle cells Intense inflammatory infiltration of the vascular wall Weakens, resulting in dilatation or aneurysm formation Thrombi Fibrosis, intimal proliferation, stenosis
9. Pathogenesis (cont.) An inflammatory infiltrate in * myocardium * upper respiratory tract * pancreas *Kidney * biliary tract
including aneurysms, with the potential for the development of: 1. coronary artery thrombosis or stenosis 2. myocardial infarction 3. aneurysm rupture 4. sudden death .
*by polymorphonuclear cells but rapidly changing to macrophages, lymphocytes (which are mostly CD8 T cells), and plasma cells * * inflammation involves all three layers of the vascular wall, with destruction of the internal elastic lamina. *In the healing phase, the lesion becomes progressively fibrotic, with marked intimal proliferation, which may result in stenotic occlusion of the vessel over time.
*by polymorphonuclear cells but rapidly changing to macrophages, lymphocytes (which are mostly CD8 T cells), and plasma cells * * inflammation involves all three layers of the vascular wall, with destruction of the internal elastic lamina. *In the healing phase, the lesion becomes progressively fibrotic, with marked intimal proliferation, which may result in stenotic occlusion of the vessel over time.