for doctors

1. DR. ARCHANA DHAVALSHANKH
PROF & HEAD, DEPT. OF PHARMACOLOGY
D Y PATIL MEDICAL COLLEGE, KOLHAPUR
Comp 1.1

2. SYLLABUS FOR PHARMACOLOGY
Sr. No. Topics
1 General Pharmacology
2 Drugs acting on A.N.S (Autonomic Nervous System)
3 Drugs acting on C.V.S (Cardiovascular System)
4 Drugs acting on C.N.S (Central Nervous System)
5 Blood (Hematinic) , Diuretics
6 Drugs acting on R.S (Respiratory System)
7 Drugs acting on G.I. Tract
8 Drugs acting on Endocrine system
9 Drugs in Chemotherapy
10 Vitamins , Vaccines,
11 Autocoids
12 Pandemic Module
13 AETCOM

3. TEXT- BOOKS FOR PHARMACOLOGY
Sr.
No.
Text Book Author Edition
1 The
Pharmacological
Basis of
Therapeutics
Goodman Gillman 13 th Edition
2 Basic and
Clinical
Pharmacology
Bertram G Katzung 14 th Edition
3 Essentials of
Medical
Pharmacology
K. D. Tripathi 8 th edition
4 Pharmacology
and Pharmaco-
therapeutics
Satoskar and
Bhandarkar
26 th edition
5 Principles of
Pharmacology
KK Sharma 3 rd edition

4. OBJECTIVES
 Need to learn Pharmacology
 Definition & Terminology
 Braches of Pharmacology
 Sources of Drug
 Sources of Drug Information

5. WHY DO WE NEED TO STUDY PHARMACOLOGY?
Therapeutic methods- Ways to treat diseases
Most diseases requires a combination of therapeutic methods
for successful treatment.
1. Drug therapy – Txt with drugs
2. Diet therapy – Tx by diet – Low salt diet for cardio diseases
3. Physiotherapy – Tx with natural physical forces (water, light
& heat)
4. Psychological therapy – Identification of stressors and
methods to reduce or eliminate stress/use of drugs

7. DEFINITIONS
1. Pharmacology = The study or science of drugs.
Pharma = Drugs Logos = Knowledge
- derived from two Greek words:
Pharmakon (Greek word for drugs) and logos (the Greek word for
science) (a discourse or treatise)
It includes physical and chemical properties, biochemical and
physiological effects, mechanism of action, therapeutic uses and
adverse effects of drugs.

8. 2. DRUG • French: Drogue – a dry herb
A single active chemical entity present in a medicine that is used for diagnosis,
prevention and treatment of diseases Broadly defined as how chemical agents
affect living processes:
- Hormones
- Neurotransmitters
- Growth factors
- Drugs (pharmaceuticals)
- Toxic agents in the environment
- NCE - The medicinal/organic chemists may create the candidate compound
(sometimes referred to as a new chemical entity, (NCE).
It is the pharmacologist who is responsible for testing it for pharmacological
activity.
Ultimately will lead to the discovery of novel drugs for therapeutic intervention.
WHO – in 1966 – “ Drug is any substance or product which is
used or intended to be used
to modify or explore physiological systems or pathological states
for the benefit of the recipient.”

9. Pharmacologist – is a scientist who
specializes in the study of pharmacodynamics
employing all kinds of biochemical, physiological
and other techniques.
Pharmacy- is a medical science concerned
with the safe & effective use of medicines
- The study of techniques involved in the
preparation, compounding, preservation & storage
of the drugs for medical use
Clinical Pharmacology – Study of
drugs in humans (patients or volunteers )

11. • Deals with ADME process.
• i.e. what the body drug does with the drug.
Pharmaco
Kinetics
• Deals with biological effects of drug, its mechanism of action of drug ,
relationship b/w plasma concentration & its response, duration of action,
• i.e. what the drug does with the body
Pharmaco
Dynamics
• Clinical applications of pharmacokinetics &
pharmacodynamic information to cure the disease.
Pharmaco
Therapeutics
• Deals with the comparative clinical evaluation of
new drug for its therapeutic efficacy & safety
Clinical
Pharmacology
• Deals with the toxicity & poisonous effects of the drugs
• Also with symptoms & treatment of poisoning.
Toxicology
Pharmacology -Subdivisions

13. Involves the study of Absorption,
Distribution,
Metabolism
(Biotransformation)
Excretion

14. Absorption

15. Distribution

16. Metabolism
Biotransformation

17. Excretion

18. Elimination

21. Site of action
Mechanism of action
Effects of drugs
Side/Adverse effects of drugs
Drug / Food interactions
Dose response / Efficacy/
potency

23. Pharmacotherapeutics
Pharmacogenetics
Toxicology

38. Sources of Drug

39. Plant Source Drug Use
Chinchona Bark Quinidine Malaria
Antiarrhythmic
Purple Foxglove Leaf Digitalis Cardiotonic
CHF
Poppy Plant
Opium
Fruit Morphine
Codeine
Analgesic
Antitussive
Antidiarrheal
Eserine Seed Anticholinesterase Myasthenia Gravis
Nicotinia Tabacum Flower Nicotine Ganglion blocker
Atropa Belladonna Anticholinergics OP Poisoning
Vinca Rosea Fruits Vinca alkaloids Anti cancer
Rauwolfia
Serpentina
Flower Risperidone Antihypertensive

43. Nature of Drug

53. 1. Sources of drug
2. Nature of drug derived from plant
3. Sources of drug information
4. Drug categories
5. Definition:
Pharmacodynamics
Pharmacokinetics
Drug
Pharmacology
Pharmacotherapeutics
Pharmacogenetics
Clinical Pharmacology
ASSIGNMENT- 1
Name
Roll No
Subject
Index
Topic
Name of
Teacher
Assignment