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Unified Data for Actionable Biomarkers
What Is BiomarkerBase?
• A manually curated database
that aggregates information
from publicly available sources
that describe the clinical use of
biomarkers.
• Provides access to biomarkers that
can’t be found through searches in
public sources.
• Links biomarker information
together by target, disease, drug,
therapeutic area, and company.
2
http://www.biomarkerbase.com
- IVD Tests cleared or approved by FDA since the end of 2002 that
utilize one or more biomarkers.
- Drugs, all FDA-approved, that include a biomarker in the label.
- Clinical Trials, phase 3 and 4, initiated since the end of 2011, which
include “marker” in the record. Phase 2 trials by Nov ‘13.
- Publications describing clinical studies that include biomarkers
from the sources above.
Current Datasets
Biomarker Definition: A nucleic acid, peptide or hormone that is potentially useful
for diagnosis, prognosis, or companion diagnosis.
3
Public sources of
biomarker information lack
connectivity and have
severe querying
limitations.
4
Query limitation #1:
Some of the most
critical information
can’t even be searched.
X
5
Query limitation #1:
Some of the most
critical information
can’t even be searched.
6
X
Query limitation #2:
Nomenclature isn’t standardized.
Search
Term
Studies
Returned
ca 125 153
ca-125 140
mucin-16 138
mucin 16 138
MUC16 0
7
8
BiomarkerBase Difference
Manually Curated
ComprehensiveClinically Focused
9
Who Uses BiomarkerBase?
Diagnostic Companies
Product development; business development; marketing
Drug Companies
Clinical trial planning; partnering; test selection
Life Science Companies
Product development; business development; marketing
Research Institutions
Licensing
10
Subscription Pricing
Single User
• $1,000 / year
• Access for one individual
Multi User
• $2,500 / year
• Unlimited users at a single
site within one company or
institution
• Multi-site licenses are also
available at discounted
pricing.
11
Amplion Research Inc.
1011 SW Emkay Drive,
Suite 200
Bend, Oregon 97702
USA
support@amplion.com
+1.503.389.1157
Contact Information
12

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Biomarker base™ Introduction

  • 1. Unified Data for Actionable Biomarkers
  • 2. What Is BiomarkerBase? • A manually curated database that aggregates information from publicly available sources that describe the clinical use of biomarkers. • Provides access to biomarkers that can’t be found through searches in public sources. • Links biomarker information together by target, disease, drug, therapeutic area, and company. 2 http://www.biomarkerbase.com
  • 3. - IVD Tests cleared or approved by FDA since the end of 2002 that utilize one or more biomarkers. - Drugs, all FDA-approved, that include a biomarker in the label. - Clinical Trials, phase 3 and 4, initiated since the end of 2011, which include “marker” in the record. Phase 2 trials by Nov ‘13. - Publications describing clinical studies that include biomarkers from the sources above. Current Datasets Biomarker Definition: A nucleic acid, peptide or hormone that is potentially useful for diagnosis, prognosis, or companion diagnosis. 3
  • 4. Public sources of biomarker information lack connectivity and have severe querying limitations. 4
  • 5. Query limitation #1: Some of the most critical information can’t even be searched. X 5
  • 6. Query limitation #1: Some of the most critical information can’t even be searched. 6 X
  • 7. Query limitation #2: Nomenclature isn’t standardized. Search Term Studies Returned ca 125 153 ca-125 140 mucin-16 138 mucin 16 138 MUC16 0 7
  • 8. 8
  • 10. Who Uses BiomarkerBase? Diagnostic Companies Product development; business development; marketing Drug Companies Clinical trial planning; partnering; test selection Life Science Companies Product development; business development; marketing Research Institutions Licensing 10
  • 11. Subscription Pricing Single User • $1,000 / year • Access for one individual Multi User • $2,500 / year • Unlimited users at a single site within one company or institution • Multi-site licenses are also available at discounted pricing. 11
  • 12. Amplion Research Inc. 1011 SW Emkay Drive, Suite 200 Bend, Oregon 97702 USA support@amplion.com +1.503.389.1157 Contact Information 12