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Echocardiographic Evaluation of Mitral Regurgitation Vincent Brinkman, MD Cardiovascular Medicine The Ohio State University
Anatomy ,[object Object],[object Object],[object Object],[object Object],[object Object],Otto, NEJM, 2001; 345:740
Etiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Otto, NEJM, 2001; 345:740
Etiology ,[object Object],[object Object],[object Object],Otto, NEJM, 2001; 345:740
Etiology ,[object Object],[object Object],[object Object],Otto, NEJM, 2001; 345:740
Etiology ,[object Object],[object Object],[object Object],[object Object],Otto, NEJM, 2001; 345:740
Physiology ,[object Object],[object Object],[object Object],[object Object],[object Object],Bonow et al., JACC 2006; 48:e1
Physiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bonow et al., JACC 2006; 48:e1
Repair vs. Replacement ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Echo Indications Indications for Transthoracic Echocardiography Class I 1. Transthoracic echocardiography is indicated for baseline evaluation of LV size and function, RV and left atrial size, pulmonary artery pressure, and severity of MR in any patient suspected of having MR.  (Level C) 2. Transthoracic echocardiography is indicated for delineation of the mechanism of MR.  (Level B) 3. Transthoracic echocardiography is indicated for annual or semiannual surveillance of LV function (estimated by ejection fraction and end systolic dimension) in asymptomatic patients with moderate to severe MR.  (Level C) 4. Transthoracic echocardiography is indicated in patients with MR to evaluate the MV apparatus and LV function after a change in signs or symptoms.  (Level C) 5. Transthoracic echocardiography is indicated to evaluate LV size and function and MV hemodynamics in the initial evaluation after MV replacement or MV repair.  (Level C) Class IIa Exercise Doppler echocardiography is reasonable in asymptomatic patients with severe MR to assess exercise tolerance and the effects of exercise on pulmonary artery pressure and MR severity.  (Level C) Class III Transthoracic echocardiography is not indicated for routine follow-up evaluation of asymptomatic patients with mild MR and normal LV size and systolic function.  (Level C)
Follow up Echo Indications Otto C. M.   Evaluation and Management of Chronic Mitral Regurgitation N Engl J Med 2001; 345:740-746, Sep 6, 2001.
The ECHO exam ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2D Echo ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2D Echo ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Color Doppler Exam ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Color Doppler Exam ,[object Object],>40 >4.4 Severe 3.0-4.4 Moderately severe 20-40 1.5-2.9 Moderate <20 <1.5 Mild Jet Area(% of left atrium) Jet Length (cm) Severity
Jet Area ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vena Contracta ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Vena Contracta <0.3cm = mild >0.6cm = severe
Vena Contracta ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Continuous Wave Doppler ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pulse Wave Doppler ,[object Object],[object Object],[object Object],Normal Blunting Reversal
Pulse Wave Doppler ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Quantifying MR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PISA Method ,[object Object],[object Object],[object Object],[object Object],Vmr ROA
PISA Method <0.2cm 2  = mild 0.2-0.29cm 2  = mod >0.4cm 2  = severe
Or . . . Assuming the MR velocity is around 5 m/s (pressure difference of 100 mmHg) and the aliasing velocity is set at 40 cm/s. Pu et al., J Am Soc Echocardiogr. 2001; 14:180.
PISA Method ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Estimating Regurgitant Volume and ROA ,[object Object],[object Object],[object Object],[object Object]
Estimating Regurgitant Volume and ROA
Regurgitant Volume Regurgitant Volume Regurgitant Fraction
Regurgitant Volume and ROA ,[object Object],[object Object],>0.40 0.30-0.39 0.20-0.29 <0.20 ROA(cm 2 ) >50 40-49 30-39 <30 Regurgitant Fraction (%) >60 45-59 30-44 <30 Regurgitant Volume (mL) Severe Moderate Mild
Regurgitant Volume by Doppler ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Integrated approach to MR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Integrated approach to MR grading MR Color Flow imaging Vena Contracta Jet Direction Severe MR PISA RV and ROA Pulse Doppler RV and ROA Mild MR From Otto, Textbook of Clinical Echocardiography. Elsevier Inc.2004 Appears to be mild >0.7cm <0.3cm Central Eccentric Central Jet No PISA seen Jet Area < 4.0 cm2 Or <20% LA area CWD not intense
Mitral Regurgitation Index
Mitral Regurgitation Index
ROA and Outcomes
Quantitative  Determinants if the Outcome of Asymptomatic Mitral Regurgitation ,[object Object],[object Object],[object Object],[object Object]
Quantitative  Determinants if the Outcome of Asymptomatic Mitral Regurgitation ,[object Object],[object Object]
Quantitative  Determinants if the Outcome of Asymptomatic Mitral Regurgitation ,[object Object],[object Object],[object Object]
MR ECHO Paramters From: American Society of Echocardiography, Recommendations for Evaluation of the Severity of Native Valvular Regurgitation with Two-dimensional and Doppler Echocardiography. 2003.
MR ECHO Paramters From: American Society of Echocardiography, Recommendations for Evaluation of the Severity of Native Valvular Regurgitation with Two-dimensional and Doppler Echocardiography. 2003.
Paramater advantages and disadvantages
Other modalities ,[object Object],[object Object],[object Object],[object Object]

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Echo Mitral Regurg

  • 1. Echocardiographic Evaluation of Mitral Regurgitation Vincent Brinkman, MD Cardiovascular Medicine The Ohio State University
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11. Echo Indications Indications for Transthoracic Echocardiography Class I 1. Transthoracic echocardiography is indicated for baseline evaluation of LV size and function, RV and left atrial size, pulmonary artery pressure, and severity of MR in any patient suspected of having MR. (Level C) 2. Transthoracic echocardiography is indicated for delineation of the mechanism of MR. (Level B) 3. Transthoracic echocardiography is indicated for annual or semiannual surveillance of LV function (estimated by ejection fraction and end systolic dimension) in asymptomatic patients with moderate to severe MR. (Level C) 4. Transthoracic echocardiography is indicated in patients with MR to evaluate the MV apparatus and LV function after a change in signs or symptoms. (Level C) 5. Transthoracic echocardiography is indicated to evaluate LV size and function and MV hemodynamics in the initial evaluation after MV replacement or MV repair. (Level C) Class IIa Exercise Doppler echocardiography is reasonable in asymptomatic patients with severe MR to assess exercise tolerance and the effects of exercise on pulmonary artery pressure and MR severity. (Level C) Class III Transthoracic echocardiography is not indicated for routine follow-up evaluation of asymptomatic patients with mild MR and normal LV size and systolic function. (Level C)
  • 12. Follow up Echo Indications Otto C. M. Evaluation and Management of Chronic Mitral Regurgitation N Engl J Med 2001; 345:740-746, Sep 6, 2001.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26. PISA Method <0.2cm 2 = mild 0.2-0.29cm 2 = mod >0.4cm 2 = severe
  • 27. Or . . . Assuming the MR velocity is around 5 m/s (pressure difference of 100 mmHg) and the aliasing velocity is set at 40 cm/s. Pu et al., J Am Soc Echocardiogr. 2001; 14:180.
  • 28.
  • 29.
  • 31. Regurgitant Volume Regurgitant Volume Regurgitant Fraction
  • 32.
  • 33.
  • 34.
  • 35. Integrated approach to MR grading MR Color Flow imaging Vena Contracta Jet Direction Severe MR PISA RV and ROA Pulse Doppler RV and ROA Mild MR From Otto, Textbook of Clinical Echocardiography. Elsevier Inc.2004 Appears to be mild >0.7cm <0.3cm Central Eccentric Central Jet No PISA seen Jet Area < 4.0 cm2 Or <20% LA area CWD not intense
  • 39.
  • 40.
  • 41.
  • 42. MR ECHO Paramters From: American Society of Echocardiography, Recommendations for Evaluation of the Severity of Native Valvular Regurgitation with Two-dimensional and Doppler Echocardiography. 2003.
  • 43. MR ECHO Paramters From: American Society of Echocardiography, Recommendations for Evaluation of the Severity of Native Valvular Regurgitation with Two-dimensional and Doppler Echocardiography. 2003.
  • 44. Paramater advantages and disadvantages
  • 45.