This document outlines topics and questions for a panel discussion on conducting community-based work in Native American/American Indian communities. The panel will discuss their experiences working with tribal communities, the unique aspects of this work, best practices for ensuring cultural awareness and respect, challenges they have faced and how to overcome them, the importance of self-awareness, their greatest successes, partnership approaches, and advice for others interested in this work. The goal is to share lessons learned on appropriate and effective ways to engage with tribal organizations and groups.