Speaker: Jimmy Lu Topics: Research Proposal and Milestone Date: 2010.10.09 WECO Lab, CSIE, FJU

1. The Research Proposal and Milestone
Speaker : Jimmy Lu
Advisor : Hsing Mei
Web Computing Laboratory(WECO Lab)
Computer Science and Information Engineering Department
Fu Jen Catholic University

2. Outline
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WECO Lab, CSIE dept., FJU
http://www.weco.net
 The steps of defining the brain
components
 The network approach for modeling
Alzheimer’s disease
 Implementation details
 Expected results
 The milestone

3. What am I doing
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WECO Lab, CSIE dept., FJU
http://www.weco.net
 A brain simulator that simulates
structural dynamics of the human
brain.
 A network dynamics approach for
modeling the Alzheimer’s disease.
 Define the brain components by
utilizing object-oriented concept.

4. The Brain Components
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WECO Lab, CSIE dept., FJU
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 There are a lot of components in the
human brain, it is extremely complex
and makes me confused even I’ve
studied neuroanatomy. Is there any
reference to help me to define the
components?
 Wikipedia -> Human Brain

5. The Brain Components
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WECO Lab, CSIE dept., FJU
http://www.weco.net
 However it is still too many
components that I can’t completely
define them
 Find out the most relevant part to the
Alzheimer’s disease
 Find out the most relevant part with
acetylcholine

6. The Connections
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WECO Lab, CSIE dept., FJU
http://www.weco.net
 How about the connections?
 Find out the connections from the
context of the books of neruoanatomy or
the wikipedia.
 Use existing imaging tools to finds out the
structural or functional connectivity.
Getting imaging data first.
Ex: Diffusion tensor imaging data.

7. How to utilizing OO concept?
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WECO Lab, CSIE dept., FJU
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 It seems that object-oriented concept
are quite suitable for defining
components of the human brain.
 However it is not appropriate to use
“inheritance” concepts only.
 I need more powerful tools.
 Design pattern[1]

8. Design Patterns
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WECO Lab, CSIE dept., FJU
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9. Network approach model
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WECO Lab, CSIE dept., FJU
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 The internet, peer-to-peer, error and
attack tolerance of complex
networks[2], network damage models[3]
 Key element: acetylcholine

10. How to verify the model
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WECO Lab, CSIE dept., FJU
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 Compare to image data

11. Expected Results
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WECO Lab, CSIE dept., FJU
http://www.weco.net
 A simple brain structural simulator
which simulate the dynamics of brain
structural connectivity of AD.
 A model which describes how ACh
effect on the brain of AD patients.
 Library of the brain components and
the connections.

12. Milestone
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WECO Lab, CSIE dept., FJU
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 October ~ February:
 Define components and connections of
the human brain
 Implementation
 Model
 February ~ April:
 Modification and verification
 Thesis writing

13. Milestone
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WECO Lab, CSIE dept., FJU
http://www.weco.net
 May:
 Prepare oral presentation
 Thesis revision

14. 2015/1/30
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http://www.weco.net
14
1. Erich Gamma, Richard Helm, Ralph Johnson and John M. Vlissides,
“Design Patterns: Elements of Reusable Object-Oriented Software”,
Addison-Wesley Professional (1994)
2. Reka Albert, Hawoong Jeong and Albert-Laszlo Barabasi, “Error and
attack tolerance of complex networks”, Nature 406 378-382 (2000)
3. C. J. Stam, W. de Haan, A. Daffertshofer, B. F. Jones, I. Manshanden, A.
M. van Cappellen van Walsum, T. Montez, J. P. A. Verbunt, J. C. de
Munck, B. W. van Dijk, H. W. Berendse and P. Scheltens, “Graph
theoretical analysis of magnetoencephalographic functional
connectivity in Alzheimer’s disease”, Brain 132 213–224 (2009)