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Vaccination progam in farm animals prof. dr Alaa Basyoni prof Hamed Attia

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Vaccination progam in farm animals
prof. dr Alaa Basyoni prof hamed attia

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Vaccination progam in farm animals prof. dr Alaa Basyoni prof Hamed Attia

  1. 1. Prof. DrProf. Dr AlaaaAlaaa BasionyBasiony ProfProf. Dr. Dr hamedhamed AttiaAttia Department of animal medicineDepartment of animal medicine Faculty of veterinary medicineFaculty of veterinary medicine Zagazig universityZagazig university VACCINATION PROGRAM IN FARM ANIMAL
  2. 2. *VACCINATION PROGRAM IN FARM ANIMAL *TYPES OF VACCINE USED *CAUSES OF VACCINE FAULER
  3. 3. INFECTIOUS VACCINESINFECTIOUS VACCINES (ANTIGENS)(ANTIGENS)  TYPES:TYPES: –– 11--modified live vaccinesmodified live vaccines intramuscular,intramuscular, subcutaneous,subcutaneous, intranasalintranasal
  4. 4. IMMUNITY DURATIONIMMUNITY DURATION –– lifelife--time (infection established,time (infection established, cellular andcellular and humoralhumoral immunity)immunity) –– one dose requiredone dose required –– annual boosters may not be requiredannual boosters may not be required
  5. 5. 22--NONNON--INFECTIOUS VACCINESINFECTIOUS VACCINES (ANTIGENS)(ANTIGENS)  TYPES:TYPES: –– killed vaccines and bacterinskilled vaccines and bacterins –– intramuscular, subcutaneousintramuscular, subcutaneous –– toxoids and leukotoxoidstoxoids and leukotoxoids –– intramuscular, subcutaneousintramuscular, subcutaneous
  6. 6.  IMMUNITY DURATION:IMMUNITY DURATION: –– 44 toto 1212 months (infection notmonths (infection not established,established, humoralhumoral immunity)immunity) –– primary dose required (priming)primary dose required (priming) –– secondary dose requiredsecondary dose required –– 33 toto 66 weeksweeks later (withinlater (within 44 months)months) –– Annual or semiannual boosters requiredAnnual or semiannual boosters required
  7. 7. VACCINE INSTRUCTIONSVACCINE INSTRUCTIONS  FOLLOW THE LABEL:FOLLOW THE LABEL:  refrigerate in use and storagerefrigerate in use and storage  use sanitary practices in useuse sanitary practices in use  keep out of sunlight in usekeep out of sunlight in use  properly dispose of opened vialsproperly dispose of opened vials after useafter use  Notice expiration date of unopenedNotice expiration date of unopened vialsvials
  8. 8. VACCINE LABEL USE DIRECTIONSVACCINE LABEL USE DIRECTIONS  FOLLOW THE LABEL:FOLLOW THE LABEL: –– dosedose –– route(s)route(s) –– withdrawal time for slaughter (withdrawal time for slaughter (2121 toto 6060 days)days)
  9. 9. VACCINE FAILURESVACCINE FAILURES  NO RESPONSENO RESPONSE ::  EfficacyEfficacy  stressstress  malnutritionmalnutrition  IMPROPER DOSE:IMPROPER DOSE:  IMPROPER ROUTE:IMPROPER ROUTE:
  10. 10.  MISHANDLEDMISHANDLED ::  nonnon--refrigeratedrefrigerated  Sunlight exposureSunlight exposure  UnsanitaryUnsanitary  STORED OPENED VIALSSTORED OPENED VIALS  EXPIRED VACCINEEXPIRED VACCINE  POOR QUALITY VACCINEPOOR QUALITY VACCINE
  11. 11. Bacterial vaccines Viral vaccines 8. Covexin* 8 9. Ultrabac® 8 4. Sheep pox vaccine Mixed vaccines 1. FMD vaccines 3. BEF Vaccine 5. PNEUMO 3 6. PNEUMO 4 2. RP Vaccine 1. BCG vaccine 2. HS Vaccines 3. Pneumo - Bac 4. Brucella Abortus Strain 19 Vaccine 7. Brucella Melitensis Vaccine Strain “REV. 1” 1. Entero – 3 Vaccine 7. CattleMaster4 8. Vira Shield 5 2. ScourGuard 3 6. Abortex 5. RB51 vaccine
  12. 12. 1-Viral Vaccine
  13. 13. 1-MD Vaccine
  14. 14. Monovalent Inactivated FMD Vaccine (type O1/93 locally isolated in Egypt) Protection of cattle, buffaloes, sheep and goats against FMD First dose: - Cattle & buffaloes 3 months & older 2 ml - Sheep & goats 1 ml - Dairy cattle revaccinated every 4 months . - Breeding calves sheep & goats revaccinated every 4-6 months. PACKAGE: Each bottle Contains 300 ml Second dose: 4 wks post 1st dose. SC 1-
  15. 15. Bivalent Inactivated FMD Vaccine (type O1/93 and type AEGY/06 locally isolated in Egypt) Protection of cattle, buffaloes, sheep and goats against FMD First dose: - Cattle & buffaloes 3 months & older 2 ml - Sheep & goats 1 ml - Dairy cattle revaccinated every 4 months . - Breeding calves sheep & goats revaccinated every 4-6 months. PACKAGE: Each bottle Contains 300 ml Second dose: 4 wks post 1st dose. SC 1-
  16. 16. : The vaccine contains virus of FMD type O (1/93) and type A (EGY/06). It is locally isolated in Egypt. It is inactivated by 2- bromoethylamine hydrobromide (BEI). Adjuvanated by aluminum hydroxide gel and purified saponin. COMPOSITION
  17. 17. INTERACTIONS: Other vaccination programs should be carried out at least two weeks before or after FMD vaccination.
  18. 18. PROPAGATION SYSTEM: Baby hamster kidney monolayer cell line (BHK). INSTRUCTIONS FOR USE: Shake the bottle before use.  the vaccine is inoculated subcutaneously in the dwelap 10-15 cm in front of the sternum.  In sheep and goats subcutaneously behind the shoulder or in the middle of the lower side of the neck.  Press on the injection site for a while then make gentle massage for a short time. The vaccine gives immunity for
  19. 19. VACCINE REACTION A painful swelling may be developed within one or two days at the site of injection . It does not influence the general condition of the animals. This swelling subsides within 10 days. No drop in milk production.
  20. 20. Aftovaxpur - 2 ml Cattle - 1ml Sheep - 6 m Inactivated polyvalent vaccine (O1, A22, SAT2, ASIA1) Type: Dose: - SC - 300 ml 3500 LE Route: Duration of immunity: Price: 3-
  21. 21. 2-Rinder Pest Vaccine
  22. 22. Attenuated T.C. Vaccine (" RBOK " strain) PACKAGE: Available in vial of 50 or 100 doses. Protection of cattle & buffalo against Rinderpest 1ml SC Solid immunity last for 5 – 6 years Dissolve the lyophilized material in 50 or 100 ml sterile chilled physiological saline solution. Use it within one hour
  23. 23. Cell culture Rinderpest vaccine is an attenuated vaccine which confers immunity for many years when inoculated at optimum conditions. Vaccine is prepared according to FAO and OIE instructions , by using the international reference " RBOK " strain . MODE OF USE: -Dissolve the lyophilized material in 50 or 100 ml (according to the dose) sterile chilled physiological saline solution. Use it within one hour. -The dose (1ml contain at least 103 TCID50 ) is injected subcutaneously. -Inoculate each animal with (1 ml ) of dissolved vaccine subcutaneously using sterile syringe. -Separate, sterile syringe is necessary for each animal.-Vaccine should be kept on ice, away from sunlight throughout the time of use. -Don’t use disinfectant, alcohol to sterile needles.-The vaccine is completely safe for Pregnant animals within the previously mentioned dose.
  24. 24. Inactivated Vaccine Protective of cattle & buffalos against BEF 2ml PACKAGE: Each bottle contains 20 ml (10 doses). SC - Second dose ( booster dose) : 2ml after 4 weeks. - The same program repeated annually. Animals must be vaccinated before summer season
  25. 25. COMPOSION: Each dose contains at least 106.5 TCID50 of the virus. PROPAGATION SYSTEM: Green monkey kidney cell line ( VERO ). VACCINATION PROGRAME: - Animals of 6 months age vaccinated with the vaccine. - First dose : 2ml injected (S/C ). - Second dose ( booster dose) : 2ml injected S/C after 4 weeks. - The same program repeated annually. Inactivated Bovine Ephemeral Fever Vaccine REMARKES: - The vaccine is safe for pregnant and lactating animals. - Animals must be vaccinated before summer season. CONTRAINDICATION: Animals clinically ill or those weakened should not be vaccinated.
  26. 26. 4- Respiratory Virus Vaccine IBR, BVD, PI- 3 & BRS diseases
  27. 27. 4-Types of Respiratory Virus Vaccines
  28. 28. 1-Egypian Respiratory Virus Vaccines
  29. 29. Combined Inactivated Respiratory Virus Vaccine Cattle & buffalo 5 ml Sheep 3 ml PACKAGE: bottle 100 ml (20 doses). Protection of cattle, buffaloe & sheep against IBR, BVD, & PI- 3 diseases IM 6 m 2nd dose 2 weeks apart 1
  30. 30. DESCRIPTION: A combined inactivated vaccine used for protection of cattle, buffaloe and sheep against IBR, BVD, & PI- 3 diseases. "PNEUMO 3" COMPOSITION: - Each dose contains not less than: - IBR 106 TCID50 - BVD 106 TCID50 - PI – 3 106 TCID50 - Adjuvants : aluminum hydroxid gel. VACCINATION PROGRAMME: - Animals vaccinated at ( 2 – 4 ) months old, 2nd dose must be given two weeks after the 1 st dose . Then revaccination should be done every 6 months. - Pregnant cow dames could be vaccinated with two doses, two months before parturition with 2 weeks interval. - Animals from non vaccinated dames could be vaccinated at age of 3-4 weeks.
  31. 31. PACKAGE: bottle of 100 ml (20 doses). Combined Inactivated Respiratory Virus Vaccine Cattle & buffalo 5 ml Sheep 3 ml Protection of cattle, buffaloe & sheep against IBR, BVD, PI- 3 & BRS diseases IM 6 m 2nd dose 2 weeks apart 2
  32. 32. " Pneumo 4" DESCRIPTION: A combined inactivated vaccine used for protection of cattle, Buffalo and sheep against IBR, BVD, PI- 3 & BRS diseases. COMPOSITION: Each dose contains not less than: IBR 106 TCID50 BVD 106 TCID50 PI – 3 106 TCID50 BRS 106 TCID50 Adjuvants : aluminum hydroxid gel. VACCINATION PROGRAMME: - Animals vaccinated at 2 – 4 months old, 2nd dose must be given two weeks after the 1 st dose . Then revaccination should be done every 6 months. - Pregnant dams could be vaccinated with two doses, two months before parturition with 2 weeks interval. - Animals from non vaccinated dames could be vaccinated at age of 3- 4 weeks.
  33. 33. 2-Forien Respiratory Virus Vaccines
  34. 34. Indications: For vaccination of healthy cattle, including pregnant cows, as an aid in preventing abortion caused by infectious bovine rhinotracheitis (IBR, bovine herpesvirus Type 1), persistently infected calves caused by bovine viral diarrhea (BVD) virus Types 1 and 2, respiratory disease caused by IBR, BVD (Types 1 and 2), parainfluenza3 (PI3 ) and bovine respiratory syncytial virus (BRSV) and leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. hardjo, L. icterohaemorrhagiae and L. pomona. CattleMaster® GOLD™ FP® 5 L5 1
  35. 35. Protection of cattle & buffaloe against IBR, BVD, PI- 3 & BRS diseases IM 2 ml Combined vaccine 2nd dose 2 weeks apart One year
  36. 36. Dosage and Administration General Directions: Vaccination of healthy cattle is recommended. Aseptically rehydrate the freeze-dried vaccine with the liquid component provided, shake well and administer 5 mL subcutaneously. In accordance with Beef Quality Assurance guidelines, products should be administered in the muscular region of the neck. Primary Vaccination: Administer an initial 5-mL dose, followed by a second 5-mL dose 3 weeks later. As an aid in preventing IBR-induced abortion and BVD persistently infected calves, administer at approximately 5 and 2 weeks prior to breeding. Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age. Revaccination: Annual revaccination with a single dose is recommended. Good animal husbandry and herd health management practices should be employed.
  37. 37. Protection of cattle & buffaloe against IBR, BVD (2 types) , PI- 3 & BRS diseases IM or SC 5 ml Combined Inactivated Vaccine 2nd dose 4 weeks apart One year 2
  38. 38. 5-Sheep Pox Vaccine
  39. 39. Protects sheep & goats against pox disease, & cattle against LSD I/D or S/C 0.5 ml Live attenuated freeze dried tissue culture vaccine one year PACKAGE: Each vial contains 100 dose.
  40. 40. Tissue Culture Sheep Pox Vaccine COMPOSITION: Each dose contains at least 102.5 TCID50. PROPAGATION SYSTEM: Green Monkey Kidney cell line ( Vero ). DOSAGE: - Reconstitute the vial contents in 50 ml physiological saline. - Each dose is 0.5 ml injected interadermally (I/D) or subcutanously (S/C). - Vaccination repeated annually. REMARKS: - The reconstituted vaccine should be used within two hours.
  41. 41. 2-Bacterial Vaccine
  42. 42. 1-BCG Vaccine
  43. 43. Strain called bacille Calmette & Guerin Developed by Albert Calmette & Camille Guerin two french investigors in 1920s attenuated strain of M. bovis 0.5 cm for cow & buffalo male calves 0.1 cm for lambs Intradermal Once / life (solid immunity) Freeze Dried B.C.G. Vaccine
  44. 44. the BCG was not an effective cattle vaccine 1. Used to protection of human and animals against tuberculosis 2. Give non-specific immunity to another diseases by stimulation the immune system as: a) Caseous lymphadenitis. b) Brucellosis. c) Haemorrhagic septicemia. d) Listeria. d) Staph. aureus. e) Strept. pyogens. f) Salmonellosis. g) Pox h) Rift Valley Fever 3. When used in fed lot animals increase the food conversion rate Used in males onlydue to vaccinated animals persist to give tuberculin test positive (false +ve) so, it interfere with test and slaughter program.
  45. 45. BCG Vaccine. COMPOSITION : * Vial containing 5 mg of lyophilized vaccine. * Vial containing 6 ml of diluent ( Sauton 1+ 3 ) INDICATIONS : 1) Provide non specific immunity against viral, bacterial and parasitic diseases. 2) Protect sheep from Pseudo tuberculosis, Pox and Rift Valley Fever. 3) Increase the immune efficacy and body weight gain of fattening calves. DIRECTIONS AND DOSAGE: The lyophilized vaccine is reconstituted with the diluent and injected I/D as follows : AnimalDilution Dose Vacc. Conc. Site Cow - calves2.5 ml 0.5 ml1 mgUnder the tail. Buffaloe - calf 2.5 ml0.5 ml1 mgSide of the neck Sheep 5 ml0.1 ml0.1 mgInner aspect of the thigh or under the fatty tail.Lambs10 ml0.1 ml0.05 ml PRECAUTIONS: 1) The vaccine should be used quickly as possible after reconstitution, and any remaining vaccine should be discarded. Un used diluted vaccine, empty vails and used syringes must be disposed hygienically. 2) Bulls, cows and buffaloes never to be vaccinated . 3) Vaccination is stopped in cases of general weakness, serious skin diseases and acute illness ( fever ) STORAGE: The vaccine should be stored in a dry place protected from direct sunlight or diffuse day light at a temperature between 4 - 8oC, not freezer. Validity : Tow years from the manufacture date. PACKAGE: A vial containing 5 doses for calves or 50 doses for sheep.
  46. 46. 2- Pasteurellosis Vaccine
  47. 47. Inactivated HS Oil Adjuvant Vaccine (type B:6) PACKAGE: bottle 300 ml. (150 dose). Protection of cattle & sheep against HS & pneumonic pasteurellosis 2 ml in cattle 1 ml in sheep IM 9 m 1
  48. 48. DESCRIPTION: Haemorrhagic septicaemia oil adjuvant is an inactivated oil emulsion vaccine used for active immunization of cattle against haemorrhagic septicaemia and pneumonic pasteurellosis. COMPOSITION: Each dose of the vaccine contains pasteurella multocida type B:6 inactivated with formalin and emulsified in oil base. VACCINATION PROGRAM: - In areas where the disease occur seasonaly animals should be vaccinated two or three weeks before the season. - Where the incidance is not seasonal, animals should be vaccinated every nine months. - When outbreaks of the disease occur, all contact stock must be vaccinated as soon as possible. RECOMENDATIONS: - Shake the vaccine vigoursly before and during use to ensure good mixing. - Allow the vaccine to reach room temperature before vaccination. - Intravenous injection must be avoided. - Animals to be vaccinated should be in good health and not suffering from any disease.
  49. 49. Inactivated Oil Adjuvant Polyvalent Pneumonic Pasteurellosis Vaccine Cattle and buffaloes: Over 100kg 2ml Under 100kg 1ml. Sheep & goat : 1ml. PACKAGE: bottles 300 ml. (150 dose for cattle, 300 dose for sheep & goat). Protection of Cattle, Sheep & Goat against pneumonic pasteurellosis. 2nd dose 4 weeks apart One year IM 2
  50. 50. Protects against H.S. in horses, mules & donkeys S/C 1 ml at 6th month 2 ml at 1 year 3 ml at 2 years 5 ml at 3 years Formalized killed vaccine 6 months 3
  51. 51. DESCRIPTION: Pneumo - bac is an inactivated oil adjuvant polyvalent pasteurellosis vaccine used for active immunization of cattle, sheep and goat against pneumonic pasteurellosis. COMPOSITION: The vaccine contains pasteurella multocida types A,B & D and pasteurella haemolytica types A & T inactivated with formalin and emulsified in oil base. VACCINATION PROGRAM: - Animals vaccinated with two doses four weeks internal. - For pregnant animals, vaccination with two doses four weeks internals at 6-8 weeks before parturition. - Animals born from vaccinated dams should be vaccinated at 8 weeks of age. - Animals born from unvaccinated dams should be vaccinated at one week age. - Revaccination with one dose annually. RECOMENDATIONS: - In areas where the disease occurs seasonally, animals should be vaccinated at 4 or 5 weeks before the season. - When outbreaks of the disease occur, all contact stock must be vaccinated as soon as possible.
  52. 52. 3-Brucella Vaccine
  53. 53. PACKAGE: Vials 10 ml contains 10 reduced doses of lyophilized vaccine ( 3-10 x 109 CFU / dose ( accompanied with 20 ml diluent. Protection of cattle, buffaloes against Brucellosis Living attenuated smooth B.abortus strain 19 in serous form or freeze dried (lyophilized vaccine). SC to female calves between 4 to 8 months old 5 successive years Full dose (standard dose): about 60 – 80 x109 microbial cells in about 2ml. Reduced dose (1/20 of full dose): It is widely used nowadays specially in un-affected herd and it is characterized by rapid decline in aglutinins. 1
  54. 54. * Used in female calves at 4 – 8 months (average 6 months). * Not used before 4 months of age due to: (1) Reticulo-endothelial system is still undeveloped so may result in low titer of antibodies (not protect against disease). (2) When given at this age, the colostrums antibodies interfere the microbial dose and so the immunity produce is low. * Not used after 8 months of age: Animal produces permanent agglutinin titer (permanent +ve serological test).
  55. 55. * Disadvantage of this vaccine: (1) Used to vaccination of female only due to it produce orchitis in bull. (2) Not use in adult female as it cause abortion except it can use in adult female in case of outbreak. (3) Interfere with control program due to it give serological +ve (5% of vaccinated animal give resistant agglutinin for 2 – 3 years). (4) Give infection and un-dutant fever to human. (5) Not prevent complete infection from udder. (6) It need to be refrigerated, problems of storage and transport at 4oC.
  56. 56. COMPOSITION: Each dose of reconstituted vaccine contains 3-10 x109 CFU of Brucella abortus Strain 19. ADVERSE REACTIONS: These occur rarely in both calves and adults , to be more sever in foreign breeds. A local swelling occurs particularly in adult cattle and there may be a sever systemic reaction manifested by fever lasting for 2-3 days. Anaphylactic shock may occur and immediate treatment with adrenaline hydrochloride ( 1m1. of 1 : 1000 diluted solution injected subcutaneously ) or Antihistaminic drug, is also recommended
  57. 57. Live attenuated vaccine of Brucella abortus rough strain RB51 10 – 34 million bacteria/2ml as one or 2 dose 30 day interval Protection cattle, buffaloes & sheep against brucellosis by B. abortus. 1 – 2 years and animals vaccinated annually SC 2
  58. 58. 1. Not result in measurable Ab titers to B. abortus using standard diagnostic tests so, not interference with eradication program of Brucellosis using such test. 2. Eliminate costs associated with resting and trace backs of false +ve reactors as in B. abortus st. 19 vaccine. 3. Not excrete in excretion and secretion of animals. 4. Used in all ages of the animals. 5. There is no any side effect on vaccinated animals. 6. Not protect animal infected with another species of Brucella as Brucella melitensis - Age: Female calves of 4 – 12 months. - Adult non-pregnant female. (Cause abortion) Advantages:
  59. 59. Brucella Melitensis Vaccine Strain “REV PACKAGE: - Vials 10 ml contains 10 doses of lyophilized vaccine (1 to 2 x 109 CFU / dose ( accompanied with 20 ml diluent. - Vials 10 ml cantains 5 doses of lyophilized vaccine ( 1- 2 x 109 CFU / dose( accompanied with 10 ml diluent. INDICATIONS AND DOSAGE: After reconstitution with the accompanied diluent, it should contain 1 to 2 x 109 CFU viable organisms per 2 ml dose, given subcutaneous to lambs and kids aged between 3 to 8 months. Vaccination is followed by the appearance of specific antibodies. Do not vaccinate pregnant or lactating females two month prior to meeting. Living attenuated B. Melitensis vaccine 3
  60. 60. COMPOSITION: Each dose of reconstituted vaccine contains 1 to 2 x 109 CFU of Brucella Melitensis “Strain Rev. 1.” ADVERSE REACTIONS: These occur rarely in both young or adult. A local swelling may occurs . Severe systemic reaction manifested by fever lasting for 2-3 days. Allergic reaction may occur . treatment with adrenaline or antihistaminic drugs should be done.
  61. 61. 3-Clostridial Vaccine
  62. 62. clostridial diseasesclostridial diseases Lamb dysentery Struck Pulpy kidney Braxy & Malignant oedema Blackleg Tetanus Black disease Bacillary haemoglobin urea Cl. perfringens type B Cl. perfringens type C Cl. perfringens type D Cl. novyi type B Cl. septicum Cl. chauvoei Cl. novyi type D Cl. tetani caused by
  63. 63. ULTRABAC® 7 • ULTRABAC 7 provides effective, protection against the following key clostridial diseases: • blackleg – Cl. chauvoei • malignant edema – Cl. septicum • black disease – Cl. novyi • gas-gangrene – Cl. sordellii • enterotoxemia, enteritis – Cl. perfringens types B, C, and D Packaging: 10-, 50-, & 200-dose vials Dosage & route: Shake well. Aseptically administer 5 mL subcutaneously, followed by a second dose 4–6 weeks later Annual revaccination with a single dose is recommended Indications: 1
  64. 64. Protects cattle, sheep & goat against 8 clostridial diseases S/C Polyvalent formalized killed vaccine 6 months 2nd dose 2 ml 5 ml 6 W1st dose 2 ml 5 ml sheep cattle 2
  65. 65. Protects cattle, sheep & goat against 8 clostridial diseases S/C Polyvalent formalized killed vaccine 6 months 2nd dose 2 ml 5 ml 6 W1st dose 2 ml 5 ml sheep cattle 3 Cubolac 8 United Biofarm
  66. 66. Protects cattle, sheep & goat against 8 clostridial diseases S/C Polyvalent formalized killed vaccine 6 months 2nd dose 2 ml 5 ml 6 W1st dose 2 ml 5 ml sheep cattle 3-Covaccin 10 10
  67. 67. Protects sheep & goat against 8 clostridial diseases S/C 1st dose 5 ml Polyvalent formalized killed vaccine 6 months 2nd dose 3 ml 6 W 4
  68. 68. 3-Mixed Vaccine
  69. 69. Inactivated Bovine Rota, Corona Viruses and E-Coli Vaccine Protection of newly born calves against diarrhoea caused by Rota, Corona viruses and E-Coli 4 ml in pregnant cow or buffalo PACKAGE: bottles of 20, 40 and 100ml. IM 2 doses at least two weeks apart to pregnant cows, the second dose given 2-3 weeks before calving. One year 1
  70. 70. COMPOSITION: Each dose contains at least 106 TCID50 of each bovine Rota and Corona viruses and 6x1010 CFU of E - Coli k99 Pili. VACCINATION PROGRAMME: - Two I/M doses at least two weeks apart to pregnant cows, the second dose given 2- 3 weeks before calving. - Revaccination with a single third dose if cows have not calved within 40 days after receiving their last dose.
  71. 71. Inactivated Bovine Rota, Corona Viruses and E-Coli Vaccine Protection of newly born calves against diarrhoea caused by Rota, Corona viruses and E-Coli IM 2 doses at least two weeks apart to pregnant cows, the second dose given 2-3 weeks before calving. 2 ml in pregnant cow or buffalo One year 2
  72. 72. Inactivated Bovine Rota, Corona Viruses and E-Coli Vaccine Protection of newly born calves against diarrhoea caused by Rota, Corona viruses and E-Coli IM 2 ml at 160 days old One year 3 Rota-vec Vaccine
  73. 73. Vaccination programme in dairy farms
  74. 74. Vaccination programme in dairy farms
  75. 75. Cow Herd VaccinesCow Herd Vaccines  Precalving Vaccination of Cows andPrecalving Vaccination of Cows and HeifersHeifers ((77 toto 99 months of pregnancy or twice a year)months of pregnancy or twice a year) 1.1. 44--way Viral BRD Vaccineway Viral BRD Vaccine 2.2. Pasteurella Bacterin & LeukotoxoidPasteurella Bacterin & Leukotoxoid 3.3. Clostridia Bacterin & LeukotoxoidClostridia Bacterin & Leukotoxoid 4.4. Scour VaccineScour Vaccine
  76. 76. 11--Lumpy Skin DiseaseLumpy Skin Disease vaccinevaccine  First injection in FebruaryFirst injection in February  The second dose every yearThe second dose every year
  77. 77. 22--FMD vaccineFMD vaccine  First injection in AprileFirst injection in Aprile  The second dose afterThe second dose after 22 weeksweeks  The next vaccine everyThe next vaccine every 44 monthsmonths
  78. 78. 33--Rift valley vaccineRift valley vaccine  First injection in AprilFirst injection in April  The second dose in OctoberThe second dose in October
  79. 79. 44--Respiratory virusRespiratory virus vaccinevaccine  Calves are vaccinated atCalves are vaccinated at 6060 days @days @ 180180 daysdays  All animals are vaccinated annually inAll animals are vaccinated annually in septemberseptember
  80. 80. 55--Viral and bacterial diseasesViral and bacterial diseases causing diarrhea vaccinecausing diarrhea vaccine (Rota , corona @ E coli)(Rota , corona @ E coli)  All pregnant cows are vaccinated atAll pregnant cows are vaccinated at 255255 days of pregnancy.days of pregnancy.  The second booster dose atThe second booster dose at 22 weeksweeks before parturitionbefore parturition
  81. 81. 6-Brucellosis vaccine (everyvaccine (every 33 years)years)  First injection in JanuaryFirst injection in January  The second dose everyThe second dose every 33 yearsyears
  82. 82. 77--Clostredial DiseaseClostredial Disease vaccinevaccine  First injection in calves atFirst injection in calves at 1414 andand 4242 days olddays old  The second dose every yearThe second dose every year  All pregnant cows are vaccinatedAll pregnant cows are vaccinated 22 weeks befor parturation .weeks befor parturation .
  83. 83. 8-pasteurellosis vaccine (Annually)vaccine (Annually)  All pregnant cows areAll pregnant cows are vaccinated at every year (invaccinated at every year (in April month)April month)
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Vaccination progam in farm animals prof. dr Alaa Basyoni prof hamed attia

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