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Literature-based	Discovery,	
Topic	Maps,	and	Machine	
Reading
AI	Seminar
University	of	Alberta
28	July,	2017
Jack	Park
TopicQuests	Foundation
©	2017,	TopicQuests Foundation
Img:	Doc	Searls:	https://www.flickr.com/photos/docsearls/5500714140
Context	and	problems	on	the	table?
• Context
• Improved	human/machine	systems	capabilities	in	the	face	of	complex,	urgent	
problems	(Engelbart)
• Problems
• Human	activity
• Collaboration
• Information	Silos
• Knowledge	representation
• User	experience
2
Solution	research	under	way?
• Collaboration	and	User	Experience
• Knowledge	gardens
• Subject	of	a	different	talk
• Open	Source:	OpenSherlock
• Information	Silos
• Literature-based	discovery
• Machine	reading
• Knowledge	federation
• Knowledge	representation
• A	range	of	representation	systems	working	together
• Hybrid	architectures
• Pandemonium-style	 architectures
3
On	Information	Silos
• An	insular	management	system†
• Silo	effect	arises	from
• Silo	mentality
• Incompatible	data	and	information	systems
• Domain	specialization
• …
• Silo	effect	creates
• Reduced	signal	to	noise	ratio	in	public	information	systems
• Redundant	resources
• Unconnected	concepts	(dots)
• ...
†https://en.wikipedia.org/wiki/Information_silo 4
Silo	Effect:	An	Example
• Alzheimer’s	Context†
• Dr.	Trumbleand	the	Tsimané Project‡
• Anthropologist	studying	evolutionary	medicine
• Indigenous	people,	Bolivia
• Higher	elderly	cognitive	performance	with	the	ApoE4	gene
• Dr.	Liddelow studying	immune	response	in	brains
• Some	people	die	without	dementia	but	with	brains	clogged	with	Alzheimer’s	pathology
• A	Quote	(emphasis	mine):
• “I	asked	Dr.	Liddelow whether	he	was	familiar	with	the	Tsimane research.	He	admitted	that	he	was	not	
— the	field	of	evolutionary	biology	is	distant	from	his	own.	But	he	said	the	hypothesis	that	the	ApoE4	
gene	evolved	to	protect	our	brains	from	the	effects	of	parasitic	infection	made	perfect	sense.	“That’s	
absolutely	in	line	with	what	we	found.	For	our	ancestors,	an	ApoE4	gene	could	have	been	beneficial,”	
Dr.	Liddelow said,	in	part	because	it	would	have	helped	the	astrocytes	go	on	the	attack.”
†
Kennedy,	P.	(2017,	July	14). An	Ancient	Cure	for	Alzheimer's? The	New	York	Times.
‡
University	of	New	Mexico. The	Tsimane Health	and	Life	History	Project. http://www.unm.edu/~tsimane/
5
Literature-based	Discovery
• Using	literature	(documents)	to	
find	new	relations	in	existing	
“knowledge”	(discovery)
• Mitigate	silo	effect
• Literature-based	Discovery,	the	
field,	was	created	by	the	
information	scientist	Don	R.	
Swanson	in	the	1980s.†
• Does	not	produce	new	
“knowledge”	as	would	laboratory	
experiments Swanson	Linking
†
see	Swanson,	Don	(1988). "Migraine	and	Magnesium:	Eleven	Neglected	
Connections". Perspectives	in	Biology	and	Medicine. 31 (4):	526–557.
Find	Intermediate	literature	B
which	links	topic	A with	topic	C
6
Swanson’s	ABC	Linking	Method†
1. Pick	a	topic	of	interest	(Raynaud’s	Disease)	
2. Search	to	find	literature	A	=	{Raynaud’s}
3. Hypothesize	that	B	(e.g.,	blood	factors)	should	be	studied	in	relation	to	
Raynaud’s
4. Search	literature	A’	=	A	∩	{blood}	
5. Notice	two	common	descriptors:	blood	viscosity,	red	blood	cell	rigidity	
6. Search	literature	C	=	{blood	viscosity}	U	{	red	blood	cell	rigidity	}
7. Notice	the	term	“Fish	Oil”
8. Search	literature	C	=	{Fish	Oil}
9. Show	{Fish	Oil}	∩ {Raynaud’s}	=	{	}	
10. Show	plausible	connection	between	Raynaud’s	and	Fish	Oil	
Show	the	literature	has	not	yet	made	
the	connection	(empty	set)
†Adapted	from:	http://www.dimacs.rutgers.edu/~billp/pubs/JASISTLBD.pdf
7
Machine	Reading:	Natural	Language	Understanding
• General	approach
• Engage
• Lexicon	/	ontology
• Parser
• Grammar	rules
• Our	approach
• Engage
• Lexicon	/	ontology	(topic	map)
• Templates
• Lenses
• Grammar	rules
8
On	Knowledge	Federation
• Knowledge	Federation	on	the	Web†
• International	Workshop,	Dagstuhl Castle,	Germany,	May	1-6,	2005
• First	Semiannual	Knowledge	Federation	Conference‡
• Dubrovnik,	Croatia,	October	20-22,	2008
†
Jantke,	K.P.,	Lunzer,	A.,	Spyratos,	N.	and Tanaka,	Y.	(Editors;	
2006) Federation	over	the	Web. Springer-Verlag,	Berlin	Heidelberg.
‡
Karabeg,	D	and	Park,	J.	(2008) First	International	Workshop	on	
Knowledge	Federation. CEUR	workshop	proceedings, http://ceur-ws.org.
9
A	Working	Hypothesis
• A	Topic	Map	can	serve	as	a	platform	for	knowledge	federation
• More	accurately:	information	resource	federation
• Federation,	in	this	context,	is	defined	as	bringing	information	resources	
together	without	filters,	and	keeping	them	organized	in	a	topic-centric	
collection.
10
Research	Questions
• Can	a	topic	map	learn	by reading?
• Can	reading	by	topic	maps	(the	process	of	topic	mapping)	perform	
literature-based	discovery?
• Perhaps	a	form	of	automating	Swanson’s	ABC	method
• What	software	architectures	support	machine	reading	in	the	context	
of	topic	mapping?
11
Towards	a	Machine	Reading	Architecture
• Workflow
• Documents	à Intermediate	
Structures	à Higher-order	
Structures
• TopicMaps
• Conceptual	Graphs
• Probabilistic	Graphs
• …
• Continuous	Literature-based	
Discovery
12
Continuous	Literature-based	Discovery:	C-LBD
• A	machine reading	many	documents	is	always	exposed	to	surprising
results
• To	the	machine,	nearly	everything	being	read	is	unconnected (Swanson’s	
empty	set)
• Over	time,	connections	may	be	discovered
• For	a	machine to	remember	and	begin	to	make	connections
• It	must	possess	a	long-term	memory,	part	of	a	kind	of	cognitive	architecture
• A	suggested	framework:
• Human-Machine	teams	which	perform	C-LBD
13
A	Cognitive	Architecture for	C-LBD
• “A	cognitive	architecture	is,	first,	a	software	architecture	that	
supports	communication	between	software	modules,	shared	
resources	and	workspaces,	and	control.	What	makes	it	cognitive	is	
that	the	modules	implement	abilities	we	generally	call	perceptual	or	
cognitive.Ӡ
• Long-term	Memory	(LTM)
• Short-term	(working)	Memory	(STM)
• Pattern	recognition
• Symbol	manipulation
• Decision	making
• Data
• …
†Cohen,	P	(2010)	Lecture 3:	Cognitive Architecture.	
http://w3.sista.arizona.edu/~cohen/cs-665-spring-2010/lectures/PDFs/Lecture3.pdf 14
Topic	Maps:	Long	Term	Memory	(LTM)
• A	Topic	Map	is	like	a	library	without	all	the	books
• A	container	for	a	universe	of	topics
• A	Topic	Map	is	indexical
• Like	a	card	catalog
• Each	topic	has	its	own	representation	(proxy)
• Improving	on	a	card	catalog,	a	topic	can	be	identified	many	different	
ways
• Captures	metadata	and	optionally	content
• A	Topic	Map	is	relational
• Like	a	good	road	map
• Topics	are	connected	by	associations	(relations)
• Topics	point	to	their	occurrences	in	the	territory
• A	Topic	Map	is	organized
• Multiple	records	on	the	same	topic	are	co-located	(stored	as	one	
topic)	in	the	map
• One	location	in	the	map	for	each	topic
Img:	Jack	Park
15
Observations	1
• A	Topic	Map	is	central	to	the	key	
question research	question
• It	serves	as	a	kind	of	memory for	
social	processes
• It	provides	a	robust	platform	for	
subject	identity
• It	also	serves	as	a	repository	for	
domain-specific	vocabularies	
(ontologies,	taxonomies,	naming	
conventions,…)
• It	federates	those	vocabularies Cultural	Algorithm	Framework†
†	After	Figure	1:	Reynolds,	RG	&	Peng,	B	(2005)	CULTURAL	ALGORITHMS:	COMPUTATIONAL	
MODELING	OF	HOW	CULTURES	LEARN	TO	SOLVE	PROBLEMS:	AN	ENGINEERING	EXAMPLE.	
Cybernetics	and	Systems	An	International	Journal Volume	36,	2005	- Issue	8	
16
Observations	2
• A	Topic	Map	is	necessary but	not sufficient to	support	discovery,	learning,	
or	problem	solving
• It	really	only	provides	a	powerful	indexicalstructure	related	to	the	key	artifacts	in	any	
universe	of	discourse:
• Actors
• Their	relations
• Their	states
• Rules,	laws,	theories,…
• To	model	those	key	artifacts,	other	representation	strategies	are	required
• Conceptual	Graphs
• Qualitative	Process	Theory
• Belief	Networks
• Deep	Learning
• …
17
Knowledge	Representation:	Symbol	Systems
• A	physical	symbol	system	(also	called	a	formal	system)	takes	physical	
patterns	(symbols),	combining	them	into	structures	(expressions)	and	
manipulating	them	(using	processes)	to	produce	new	expressions.†
• We	consider	the	identifier of	a	topic	in	a	topic	map	as a	symbol
• Example	base	structure:	RDF	triples	
• {	subject	symbol,	predicate	symbol,	object	symbol	}
• A	goal:
• Structures	which	contain	more	aspects	of	the	situation	being	represented	
than	simply	the	actors	and	their	relationship
† https://en.wikipedia.org/wiki/Physical_symbol_system
18
asA?
• For	taxonomy,	we	have	isA
• And	its	variants
• subclassOf
• instanceOf
• For	roles,	we	do	not	have	asA
• Instead,	we	model	roles
• Ulam quote
• Towards	an	ideal	structure
• {	subject	symbol,	subject	role	symbol,	predicate	
symbol,	object	symbol,	object	role	symbol	}
• Stanislaw	Ulam to	Gian-Carlo	Rota †	:
• Convinced	that	perception	is	the	key	to	
intelligence,	Ulam was	trying	to	explain	the	
subtlety	ofhuman perception	by	showing	
how	subjective	it	is,	how	influenced	by	
context.	He	said	to	Rota,	"When	you	perceive	
intelligently,	you	always	perceive	a	function,	
never	an	object	in	the	physical	sense.	
Cameras	always	register	objects,	but	human	
perception	is	always	the	perception	of	
functional	roles.	The	two	processes	could	not	
be	more	different....	Your	friends	in	AI	are	
now	beginning	to	trumpet	the	role	of	
contexts,	but	they	are	not	practicing	their	
lesson.	They	still	want	to	build	machines	that	
see	by	imitating	cameras,	perhaps	with	some	
feedback	thrown	in.	Such	an	approach	is	
bound	to	fail...”
†Hofstadter,	DR	(1995).	On	Seeing A‘s and	Seeing As	
https://web.stanford.edu/group/SHR/4-2/text/hofstadter.html
19
Context,	Scopes
• When	a	claim	is	asserted,	that	claim	is	surrounded	by	context
• We	can	say	that	every	claim	has	a	biography
• A	biography	can	include
• Historical	records
• Specific	dates
• Experiments
• …
• An	ideal	symbol	structure	would	provide	for	representation	of	
biographical	entailment
20
TopicMap Structure
•Topics	as	Actors
•Topics	as	Role	Players
•Topics	as	Relations
•Topics	as	Types
•Topics	as	Biographies
Relation	
Biography
Actor	
Type
Relation	
Type
Actor	
Type
Role	Type Role	Type
Relation ActorActor
The	meaning of	this	Relation	is	
precisely:	An	Actor	playing	a	Role	is	
in	a	particular	Relation	with	another	
Actor	playing	a	Role,	in	the	context	
of	biographical	records.
Note:	Since	this	Relation	is	a	Topic,	
it,	too,	can	be	an	Actor	in	other	
Relations
21
Machine	Reading:	Swanson’s	Example
• Silo	A • Silo	B • Machine	Reading	collects	
graph	structures	from	
different	sources
• Form	tuple-like	structures	
which	are	graphs
22
Machine	Reading:	Topic	Mapping
• TopicMap Process
• Rule:
• One	Location	in	the	Map	for	each	
Subject
• Federates	(merges	topics	about	
the	same	subject)	collected	from	
different	resources
• Federation	does	a	Union on	
topics	from	disparate	sources
• Federation	Intersects silos	
around	common	topics
• Topic	Map
23
Towards	a	“Cognitive”	Platform:	OpenSherlock*
• OpenSherlockis:
• A	Topic	Map	for	information	resource	identity	and	organization
• A	HyperMembrane information	fabric	structure
• A	society	of	agents system	which	can
• Read	documents
• Process	information	resources
• Maintain	the	topic	map
• Maintain	the	HyperMembrane
• Build	and	maintain	models
• Perform	discovery	tasks
• Physical	process	discovery
• Literature-based	discovery
• Theory	formation
• Answer	questions
• Agents	are	coordinated	by:
• A	blackboard	system
• A	dynamic	task-based	agenda
• Event	propagation	and	handling
• Stream	processing
*OpenSherlock is	an	open	source	mostly	
Java-based	research	platform.
24
OpenSherlock’s Use	Cases
1) Merge	decision	and	implementation	for	topic	maps
2) Research:	machine	reading
3) Literature-based	discovery	across	the	entire	topic	map
4) Question	answering
5) (eventually)	Theory	formation,	process	discovery
25
Machine	Reading	in	OpenSherlock
• Process	Loop:
• For	a	given	document
• For	every	paragraph	in	that	document
• For	every	sentence	in	each	paragraph
• Read the	sentence
Each	Document	has	a	
Blackboard	(STM)
Each	Paragraph	has	a	
Blackboard	(STM)
Each	Sentence	has	a	
Blackboard	(STM)
26
Sentence	Reading
• First	Step:
• Process	sentence	into	WordGrams†
• WordGramobjects	are	shared	across	sentences
• Count	of	sentence	identifiers	associated	with	each	object	serves	as	basis	for	probabilistic	models
• WordGrams can	represent	topic	labels	(names)
• Second	Step:
• Where	possible
• Transform	WordGrams into	N-Tuples‡
• By	way	of	Triple	Structures:	{	Subject	WordGram,	Predicate	WordGram,	Object	WordGram }
• N-Tuples	form	the	HyperMembrane
• N-Tuples	reflect	structures	in	the	TopicMap
• Where	not	possible
• Try	to:
• Locate	noun	phrases
• Locate	verb	phrases
† A	container	of	words,	from	1	to	8	words	per	container
‡ A	container	of	symbols	based	on	words	in	WordGrams and	
topics	from	the	TopicMap.	A	collection	of	N-Tuples	forms	
what	we	call	a	HyperMembrane.	It	is	the	final	step	between	
reading	and	adding	resources	to	the	topic	map.
27
Sentence	Reading	as	an	Iterative	Process
• Since	the	same	WordGram objects	serve	many	sentences
• Any	change	of	state	in	a	given	WordGram affects	every	sentence	it	serves
• Change	from	Unknown to	Noun,	Noun	Phrase,	Verb	or	Verb	Phrase
• WordGram change	events	enable	unfinished	(not	fully	read)	sentences	to	
iterate	and	possibly	finish.
28
Sentence	Reading	Revisited
• Sometimes
• TopicMap recognizes terms
• Mostly
• Sentence	is	read	by	pattern	recognition	tools
• IF-THEN	sentence	structure	rules		(Grammar	rules)
• Augmented	 by	Lenses
• Frame	Semantics	(e.g.	FrameNet)† (Templates)
• TopicMap learns from	those	results
†	Baker,	CF,	Fillmore,	CJ,	Lowe,	JB	(1998).	The	
Berkeley	Framenet Project.	COLING	'98	
Proceedings	of	the	17th	international	
conference	on	Computational	 linguistics,	
Volume	1
29
Lenses
• Domain-specific	interpreters	which	detect	structures
• Taxonomy
• Causality
• Biomedical
• Geophysical
• …
• Can	include
• Rules
• Conceptual	Graphs
• Deep	learning
• Process	models
• Built	and	maintained	while	reading
• Predict	while	reading	– Anticipatory	Reading
• …
30
Transform	WordGram Triples	to	N-Tuples
• Normalized	N-Tuple
• A	structure	where	the	subject,	predicate,	and	object	are	normalized
• Nouns	and	verbs	transformed
• CO2,	Carbon	Dioxide,	…	à CO2
• causes,	is	caused	by,	…	à cause
• Two	sentence	example
• CO2 is a cause of climate change.
• Climate change is caused by carbon dioxide.
• Both	result	in	the	same	structure:
• { CO2, cause, climate change }
31
About	N-Tuples
• An	N-Tuple is	a	structured	record	of
• Topics	in	the	topic	map
• Those	topics	are	harvested	from	text
• An	N-Tuple takes	the	form:
• {	Subject,	Predicate,	Object	}
• Where
• Subject	and/or	Object	can	be	one	of:
• A	topic	from	the	topic	map
• Another	N-Tuple
• An	N-Tuple is	identifiedby	the	identities	of	the	terms	it	contains
• When	thinking	in	terms	of	terms	(words)	read	from	documents,	the	identities	(numeric	representations)	of	
those	terms	form	the	identity	of	the	N-Tuple object.
• N-Tuples are	content	addressable
• Disambiguation	of	subjects	is	a	topic	mapping process
• Learning means	continuous	refinement	of	subject	identity
• Ambiguities	can	also	be	solved	through	machine	learning	and/or	human	intervention
Note:	as	a	system	of	
symbols,	a	subject,	or	
object,	or	another	N-
Tuple	refers	to	the	
symbol which	serves	as	
that	object’s	identifier
32
A	Simple	Example
• Read	this	sentence:
• Gene expression is caused by soluble hormones binding to a
plasma membrane hormone receptor
• Topic	Map	recognizes:
• Gene expression ß GeneExpression
• soluble hormones ß SolubleHormone
• plasma membrane hormone receptor ß PlasmaMembraneReceptor
• Software	agents	transform:
• is caused by ß Cause
• binding to ß Binds
• Final	semantic	structure	(N-Tuple):
• { {SolubleHormone, Binds, PlasmaMembraneReceptor},
Cause, GeneExpression }
33
A	Complex	Example
• The	Sentence:
• The pandemic of obesity, type 2 diabetes mellitus (T2DM) and
nonalcoholic fatty liver disease (NAFLD) has frequently been
associated with dietary intake of saturated fats (1) and
specifically with dietary palm oil (PO) (2).
• Expected	WordGram Triples:
• Obesity associated with saturated fats
• Obesity associated with palm oil
• T2DM associated with saturated fats
• T2DM associated with palm oil
• NAFLD associated with saturated fats
• NAFLD associated with palm oil
34
Just	One	Triple—In	3	Slides—The	Predicate
{
"pred":	{
"gramSize":	"2",
"sentences":	["ef471f0c-08c9-4097-ac17-354a32944fe1"],
"vers":	"1489448293804",
"words":	"associated with",
"lexTypes":	["vp"],
"predicateTense":	"present",
"id":	"27637.27587",
"gramType":	"pair",
"lensCodes":	["BioLens"]
},
35
The	Object
"obj":	{
"dbpo":	 {
"@percentageOfSecondRank":	"0.0",
"@URI":	"http://dbpedia.org/resource/Saturated_fat",
"@support":	 "455",
"@surfaceForm":	"saturated fats",
"@offset":	"156",
"@similarityScore":	"1.0",
"@types":	""
},
"gramSize":	"2",
"sentences":	["ef471f0c-08c9-4097-ac17-354a32944fe1"],
"synonyms":	["27739."],
"vers":	"1489448293876",
"words":	"saturated fats",
"lexTypes":	["np"],
"id":	"27738.13882",
"gramType":	"pair"
},
DBPedia
recognized	
a	topic
WordNet
returned	a	
synonym
36
The	Subject	and	WordGram Triple	Identity
"id":	"27000._27637.27587_27738.13882T",
"subj":	{
"dbpo":	 {
"@percentageOfSecondRank":	"1.0799338377810428E-21",
"@URI":	"http://dbpedia.org/resource/Obesity",
"@support":	 "3012",
"@surfaceForm":	"obesity",
"@offset":	"16",
"@similarityScore":	"1.0",
"@types":	"DBpedia:Disease"
},
"gramSize":	"1",
"sentences":	["ef471f0c-08c9-4097-ac17-354a32944fe1"],
"vers":	"1489448293875",
"words":	"obesity",
"lexTypes":	["n"],
"id":	"27000.",
"gramType":	"singleton"
}
DBPedia
recognized	
a	topic
37
Pandemonium:	Cognitive	Architectures	Again
• Oliver	Selfridge’s	1958	program	
Pandemonium† suggests	a	different	
framework:
• Demons	which	provide	opinions	on	some	state	
of	affairs	(feature	detectors)
• Demons/agents	which	analyze	those	opinions
• Demons/agents	which	make	decisions
• WordGrams as	feature	detectors
Img:	Wikipedia
†	Selfridge,	OG	(1959).	Pandemonium: A	paradigm	for	learning.	In	
Symposium	on	the	mechanization	of	thought	processes. London:	
HM	Stationary	Office
38
WordGrams:	Pattern	Recognition	Demons
• A	demon	is	a	sensor
• Individual	demons	focus	on	one	thing.
• A	WordGram represents	a	word	or	a	phrase
• It	serves	as	a	sensor	for	instances	of	self in	sentences	being	read
• A	demon	shouts according	to	the	strength	of	its	response	to	a	situation
• A	WordGram shouts according	to	the	degree	to	which	it	is	known	to	the	
TopicMap
• If	a	WordGramrepresents	the	label	for	a	single	topic,	it	wins
• If	a	WordGramrepresents	the	label	for	multiple	topics,	ambiguity exists
• Expectation	failure	event
• If	a	WordGramis	a	known	noun/noun	phrase,	it	shouts but	does	not	necessarily	win
• If	a	WordGramis	not	yet	known,	it	is	relatively	silent
39
Pandemonium	Again
• An	Opportunity	to	Explore	Related	and	Hybrid	Architectures
• More	and	different	pattern	recognition	demons
• Neural	Nets
• Analogy
• Anaphoric	Reference
• Subject	Disambiguation
• …
• Probabilistic	Graphs
• Bayesian	belief	networds
• Neural-symbolic	hybrids†
40
†	Tarek	R.	Besold,	Artur d’Avila Garcez,	Isaac	Noble	(eds.)	(2017)	Pre-
Proceedings	of	the	12thInternational	Workshop	on	Neural-Symbolic	
Learning	and	Reasoning	NeSy’17	
http://daselab.cs.wright.edu/nesy/NeSy17/nesy17_pre-proceedings.pdf
Looking	Ahead
• Technologies	I	would	like	to	explore	with	the	OpenSherlock ecosystem:
• Distributed	Prolog
• Probabilistic	Prolog
• UIMA-based	ecosystems	to	include
• Renaud	Richardet’s Sherlok
• BlueBrain’s Bluima
• Petr	Baudiš’s YodaQA
• CMU’s	OAQA
• WordGrams
• TensorFlow
• …
• A	grand,	unifying	wishlist:
• A	global	ecosystem	of	opensource	“cognitive”	systems,	all	working	with	humans	on	
quests	to	solve	and/or	prevent	complex,	urgent	problems.
• Collaborations	with	commercial	(closed	source)	platforms	is	included	in	that	wish.
41
Completed	Representation
antioxidants
kill
free	radicals
Contraindicates
macrophages	use
free	radicals	to	
kill	bacteria
Bacterial	Infection Antioxidants
Because
Appropriate	For
Compromised	 Host
Let	us	co-create	woven	information	fabrics
jackpark@topicquests.org
http://www.topicquests.org/
https://slideshare.net/jackpark/
https://github.com/topicquests	
42
Acknowledgments:
Kennan	Salinero
Mark	Szpakowski
Patrick	Durusau

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