Alpha-Beta adrenergic mixed blockers like carvedilol and labetalol combine alpha and beta blocker effects to lower heart rate and blood pressure. They are used to treat hypertension, pheochromocytoma, heart failure, angina, myocardial infarction, and left ventricular dysfunction. Common adverse reactions include tiredness, bradycardia, hypotension, wheezing, diarrhea, nausea, dizziness, and vertigo. Dosages vary based on the condition and can be administered orally or intravenously.

1. Speaker:
BUSHRA KHAN

2. Alpha-Beta Adrenergic mixed blockers combine
the effects of alpha and beta blocker medicines.
Common names of Alpha Beta blockers medicine
are:
 CARVEDILOL
 LABETALOL

3. BRAND NAME: Normodyne, Trandate,
Hybloc.
PHARMACOLOGICAL CLASS: α/β adrenergic
blocker
THERAPEUTIC CLASS: Cardiovascular agent
ROUTES: Oral (p.o), IV
DOSAGE FORM: Tablets, Parentral.

4. PHARMACOLOGY / MECHANISM:
α
blocker
β
blocker
Decrease
HR/BP

5. INDICATIONS:
HYPERTENSION
PHEOCHROMOCYTOMA

6. DOSES:
Hypertension
Oral:
I.D: 100mg po bid
M.D: 200-400mg po bid.
Parentral:
Repeated IV Inj.: I.D: 20mg slow IV inj. with 2 min period.
ER Hypertension
Pheochromocytoma
Pediatric dose:
PO:
1-2mg/kg 12 hourly; may increase to 10mg/kg 6 hourly
IV:
0.25-0.5mg/kg over 2 minutes repeated every 10 minutes if required
For infusion, 50mg/kg in 50ml of compatible IV fluid at 0-3ml/hr (0-
3mg/kg/hr)

7. BIOAVAILABILITY 25%
PROTEIN BINDING 50%
METABOLISM Liver
HALF-LIFE 6-8hr tab
5.5hr IV
EXCRETION Urine

8. CONTRAINDICATIONS:
Sinus bradycardia
Cardiogenic shock
Cardiac failure
Asthma

9. ADVERSE REACTIONS:
Body as a Whole:
Tiredness,
Fatigue
Cardiovascular System:
Bradycardia,
Cold extremities,
Hypotension,
Respiratory System:
Wheeziness,
Digestive System:
Diarrhea,
Nausea,
Hepatitis
Nervous System:
Dizziness,
Vertigo, Light-headedness

10. DRUG INTERACTIONS:

11. Speaker:
MADIHA AHMED

12. BRAND NAME: Coreg , Carvil, Dilatrend,
Eucardic, Carloc.
PHARMACOLOGICAL CLASS: α/β Adrenergic
blocker
THERAPEUTIC CLASS: Cardiovascular agent
ROUTES: Oral (p.o)
DOSAGE FORM: Tablets, Capsules .

13. PHARMACOLOGY / MECHANISM:
α
blocker
β
blocker
Decrease
HR/BP

14. INDICATIONS:
HYPERTENSION HEART FAILURE MYOCARDIAL INFARC
ANGINA LV DYSFUNCTION CORONARY ARTERY D

15. IRT:
I.D: 6.25 mg po bid cf.
M.D: 6.25 - 25 mg po bid
cf.
ERC:
I.D: 20 mg p.o od
Max dose: 80 mg /day
IRT:
I.D: 3.125 mg po bid for
2 weeks.
ERC:
I.D: 10 mg po od for 2
weeks.
IRT:
I.D: 6.25 mg po bid
cf.
M.D: 6.25 -25 mg po
bid cf.
Max dose: 50
mg/day
Hypertension
Heart Failure Angina
DOSE:
IRT:
I.D: 6.25 mg po bid .
M.D: If tolerated, then
increased to 12.5 mg
bid
ERC:
I.D: 20 mg po od .
L.V
dysfunction
Pediatric Dose:
0.08mg/kg 12 hrly; if tolerated, increase gradually to
a maximum of 0.5-0.75mg/kg 12 hourly.

16. BIOAVAILABILITY 25-35%
PROTEIN BINDING 98%
METABOLISM Liver
HALF-LIFE 7-10 hours
EXCRETION Urine: 16%,
Feces: 60%

17. CONTRAINDICATIONS:
Severe bradycardia
Bronchial asthma
Cardiogenic shock
Hepatic impairment
Hypersensitivity

18. ADVERSE REACTIONS
Body as a whole:
Fatigue
Cardiovascular System:
Bradycardia,
Hypotension,
Angina
Gastrointestinal System:
Diarrhoea,
Nausea,
Vomiting
Musculoskeletal System:
Arthralgia

19. DRUG INTERACTIONS: