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Pharmaceutical gel

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Pharmaceutical gel

  1. 1. GELS &MAGMAS
  2. 2. BUSHRA KHAN 11742 INTRODUCTION
  3. 3. GELS  Gels are an excellent formulation for several routes of administration. They are useful as liquid formulations in oral, topical, vaginal, and rectal administration. Gels can be clear formulations when all of the particles completely dissolve in the dispersing medium. A colloid in which the solid disperse phase forms a network in combination with the fluid continuous phase, resulting in a viscous semirigid sol.
  4. 4. CLASSIFICATION OF GELS GELS ARE CLASSIFIED AS SINGLE PHASE GEL SYSTEM TWO PHASE GEL SYSTEM
  5. 5. SINGLE-PHASE GEL Single phase gel consist of organic macromolecules distributed uniformly throughout a liquid. EXAMPLES:  Carbomer , Tragacanth
  6. 6. TWO PHASE GEL: Gels that contain small, descrete particles, Are thixotropic (semisolid on standing but liquid when shaken) EXAMPLE: Alluminium hydroxide
  7. 7. WAJIHA RAZA 11807
  8. 8. TYPES OF GELS THERE ARE THREE TYPES OF GELS: 1. HYDROGELS 2. XEROGELS 3. ORGANOGELS
  9. 9. CLOBETASOL PROPIONATE- TERMOVATE GEL DERMATOLOGIC: ANTIPRURITIC
  10. 10. VOLTARENGEL The standard recommended Voltaren Gel dosage for treating osteoarthritis
  11. 11. ACITIC ACID-ACI-JEL USED: VAGINAL: RESTORATION AND MAINTENANCE OF ACIDITY.
  12. 12. MADIHA AHMED 11761
  13. 13. GELLING AGENT Gelling agent are material used to thicken & stabilize liquid solutions. They dissolve in the liquid as colloid mixture that forms an internal structure giving the resulting gel an appearance of a solid matter.
  14. 14. COMMON GELLINGAGENTS ARE:  Acacia  Pectin  Strarch  Tragacanth  Xanthan gum  Alginic acid (seaweed)  Animal/vegatable fats: lard, cocoa butter  Gelatin  Bentonite, veegum (magnesium aluminum silicate)  Carboxymethylcellulose (CMC) and other cellulose derivatives  Carbomer resins (carbopols)  Colloidal silicon dioxide  Polyvinyl alcohol (PVA)  Petrolatum, mineral oil/polyethylene gel.
  15. 15. ROUTES OF ADMINISTRATION
  16. 16. HIRA ARSHAD 11752 JAVERIA NAMEEM 11757
  17. 17. MAGMA Two phase systems with large particle size or floccules of small distinct particles are called “MAGMA”. It is commonly known as Milk Magnesia. EXAMPLE:  BENTONITE MAGMA
  18. 18. METHOD OF PREPRATION Method of Preparations: There are two methods of preparations: (a) Hydration method and (b) Hydration and Precipitation method.
  19. 19. HYDRATION METHOD: Light magnesium oxide (MgO) is hydrated with water to produce magnesium hydroxide [Mg (OH)2]. MgO + H2O ® Mg(OH)2. This method is followed by industries and in Milk of Magnesia USP.
  20. 20. Hydration and Precipitation method: A solution of sodium hydroxide (NaOH) is triturated with light magnesium oxide to form a smooth cream. It is diluted with water. MgSO4 + 2NaOH = Mg(OH)2¯ + Na2CO3. MgO + H2O = Mg(OH)2¯ Precipitation formed The precipitation is mixed with chloroform water to give the final preparation.
  21. 21. PREPARATION OF BENTONITE MAGMA
  22. 22. IMPORTANCE OF MAGMAS AND GELS IN DOSAGE FORM Glycogelation gels are frequently used as a basis for medicated pastilles. They are also used in the formulation of some suppositories. E.g. Glycerin suppositories BP. Gelatin gels are employed in the preparation of hard and soft capsules that may be used to mask the unpleasant tastes of solid and liquids.
  23. 23. IN MICROBIOLOGICAL MEDIA:- Agar and gelatin gels are used as solid media for the culture of micro-organism.
  24. 24. AS A LUBRICATING AGENT :- Gels also used as a lubricating agent in pharmaceutical preparation. It is mainly used as a drug delivery vehicle. lubricating gels are also used as a resistance of gamma radiation. It is harmless to skin, delicate tissues and mucous membranes.
  25. 25. Other uses Cosmetic and styling tools: Hair gel to control hair, make hair shiny or even to flatten hair. Body gel to make skin smooth, shiny and soft. Silicone gel used to fill breast implants and to cover scars on the body or face.

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