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,  COPD: CPT 1 UTECH  Dr E. Watson PharmD.
Learning Objectives :  upon completion of this lecture, the student should be able to   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Learning Objectives Cont’d. ,[object Object],[object Object],[object Object],[object Object]
Key Points ,[object Object],[object Object],[object Object]
Key Points cont’d. ,[object Object],[object Object]
Key Points cont’d. ,[object Object],[object Object],[object Object]
Definition: National Heart, Lung and Blood institute (NHLBI) and WHO ,[object Object],[object Object],[object Object]
Definition: GOLD ,[object Object],[object Object]
Chronic Bronchitis ,[object Object],[object Object],[object Object]
Emphysema ,[object Object]
Emphysema ,[object Object],[object Object]
Chronic Asthma ,[object Object],[object Object],[object Object]
Risk factors: Major ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Risk factors: Minor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology; Chronic Bronchitis ,[object Object],[object Object]
Pathophysiology; Chronic Bronchitis ,[object Object],[object Object]
Pathophysiology; Chronic Bronchitis ,[object Object],[object Object]
Pathophysiology; Emphysema ,[object Object],[object Object],[object Object]
Pathophysiology; Emphysema ,[object Object],[object Object]
Clinical assessment ,[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory Test. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classification of COPD by severity. Stage Lung Function Stage 1:  Mild COPD  FEV1/FVC < 70% FEV1  >  80% predicated  Stage 2:  Moderate COPD   FEV1/FVC < 50 - 70% FEV1 < 80% predicated  Stage 3  Severe COPD  FEV1/FVC < 30 - 70% FEV1 < 50% of pred. Stage 4:  Very Severe COPD   FEV1/FVC < 70% FEV1  < 3 0% predicated or FEV1 is < 50% predicated and respiratory failure
Differentiating Characteristics Chronic Bronchitis Emphysema Overweight (blue bloater)   Thin (pink puffer)   Mild Dyspnea   Severe Dyspnea   Copious Sputum Scanty Sputum   Frequent Infections Less frequent Infections   Hypoxemia Hypoxemia uncommon   Barrel chest Flattened Diaphragm   Cor pulmonale Diffusion  capacity decreased
Factors Determining Severity of Chronic COPD.  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Components of COPD Management. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Goals of Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Goals of Therapy ,[object Object],[object Object],[object Object]
Non-Pharmacological Management. (NPT) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Discontinue Smoking ,[object Object],[object Object],[object Object],[object Object]
Chest Physiology ,[object Object],[object Object],[object Object]
Breathing Exercises ,[object Object],[object Object],[object Object]
Rehabilitation ,[object Object],[object Object],[object Object],[object Object]
Preventative Measures ,[object Object],[object Object],[object Object]
Pharmacological Management of COPD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Oxygen Therapy ,[object Object],[object Object]
Oxygen Therapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Anticholinergics  (e.g. Ipratropium Bromide, Atropine, Glycopyrrolate, Tiotropium bromide ,[object Object],[object Object],[object Object],[object Object]
MOA ,[object Object],[object Object],[object Object]
MOA ,[object Object],[object Object],[object Object],[object Object]
Dosing ,[object Object],[object Object],[object Object],[object Object],[object Object]
Short acting Beta Agonist (salbutamol, albuterol  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MOA / DOSE ,[object Object],[object Object],[object Object]
Long Acting Beta  Agonist;  (salmeterol, formeterol)   ,[object Object],[object Object],[object Object],[object Object]
Combination Therapy ( Ipatropium/Albuterol) ,[object Object],[object Object],[object Object],[object Object]
Theophylline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dosing ,[object Object],[object Object],[object Object],[object Object],[object Object]
Oral Steroids ,[object Object],[object Object],[object Object],[object Object]
Inhaled steroids ,[object Object],[object Object]
Antibiotics ,[object Object],[object Object],[object Object]
Antibiotics ,[object Object],[object Object],[object Object],[object Object]
Summary of Therapy by Stage.
Measure of Drug Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Measure of Drug Effects ,[object Object],[object Object],[object Object],[object Object]
Monitoring for Efficacy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Monitoring for Toxicity ,[object Object],[object Object],[object Object]
Role of the Pharmacist in the management of COPD. ,[object Object],[object Object],[object Object]
Role of the Pharmacist in the management of COPD. ,[object Object],[object Object]
Complications of COPD ,[object Object],[object Object],[object Object],[object Object]
Take Home Points/ Summary. ,[object Object],[object Object],[object Object],[object Object]
Take Home Points/ Summary. ,[object Object],[object Object],[object Object],[object Object]
Take Home Points/ Summary. ,[object Object],[object Object],[object Object],[object Object]
References ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The End Questions

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Copd lecture notes

  • 1. , COPD: CPT 1 UTECH Dr E. Watson PharmD.
  • 2.
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  • 22. Classification of COPD by severity. Stage Lung Function Stage 1: Mild COPD FEV1/FVC < 70% FEV1 > 80% predicated Stage 2: Moderate COPD FEV1/FVC < 50 - 70% FEV1 < 80% predicated Stage 3 Severe COPD FEV1/FVC < 30 - 70% FEV1 < 50% of pred. Stage 4: Very Severe COPD FEV1/FVC < 70% FEV1 < 3 0% predicated or FEV1 is < 50% predicated and respiratory failure
  • 23. Differentiating Characteristics Chronic Bronchitis Emphysema Overweight (blue bloater) Thin (pink puffer) Mild Dyspnea Severe Dyspnea Copious Sputum Scanty Sputum Frequent Infections Less frequent Infections Hypoxemia Hypoxemia uncommon Barrel chest Flattened Diaphragm Cor pulmonale Diffusion capacity decreased
  • 24.
  • 25.
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  • 51. Summary of Therapy by Stage.
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Notes de l'éditeur

  1. Students to fill in toxicities.