Sass and Compass can be used to: 1. Create smarter sprites to reduce HTTP requests by using Sass functions like inline-image. 2. Optimize CSS for specific browsers using selective CSS3 mixins to target only needed properties. 3. Use Sass color functions to pick and manipulate colors directly in code. 4. Take advantage of the @extend feature to write CSS in a more object-oriented way and reduce code redundancy. 5. Convert existing CSS to Sass syntax using the sass-convert command.