Slides from the Pistoia Alliance European Conference in London on Tuesday 19th April 2016.

1. Internet of Medical Things
Yury Rozenman,
Qualcomm Life, Business Development
April 19th, 2016 / London, UK
© 2016 Qualcomm Life. All rights reserved.

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Smart phone adoption is unprecedented
2X faster than internet, 3X faster than social media
Sources: Pew Research, Ever Accelerating Rate of Technology Adoption, March 2014 Nielsen Telecom Research and Insights, Sept. 2011
50
40
30
20
10
0
1870 80 90 1900 10 20 30 40 50 60 70 80 90 2000 10 2014
Electricity (46)
Telephone (35)
Radio (31)
Television (26)
PC (16)
Mobile Phone (13)
The Web (7)
2014
Smart Phone
(3 years)
// FIRST COMMERCIALLY AVAILABLE YEAR //
//#ofyearstoreach25%adoptionintheUS//

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////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////Service Industries Over 20 Years…Then and Now…
To
Mobile Shopping
Mobile Banking
Mobile Reservations
From
In-store Shopping
Banking Teller
Travel Agents

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4
How Does Healthcare Compare?
Facility based
Inconvenient
Delayed
Manual
Disconnected
Episodic
Unaffordable

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PRIMARY
CHRONIC DISEASE
COMPLEX
CHRONIC DISEASE
$80B
Amateur Athletics
Consumer Fitness
Fitness/Exercise
Stress Management
Diabetes
Hypertension
Metabolic Syndrome
Trauma / Burn
Myocardial Infarction
Pulmonary Failure
Stroke
Surgery
Critical Care
$350B
FITNESS
WELLNESS
$10B
$3000/day$300/day$3/day$0.30/day
Heart Failure
COPD
CAD
Cancer
Renal
MDD
ACUTE
CARE
Heart Failure
COPD
CAD
Cancer
Renal
MDD
HEALTH&
VITALITY
(CAKE)
DEATH
HHome Care Hospital Care
$3000/day$300/day$3/day$0.30/day
Spectrum of Care

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////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////////Internet of Medical Things (IoMT) Connects…
Home
Diagnostics Therapeutics Biometrics

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8© 2015 Qualcomm Life. All rights reserved.
IoMT for Home Diagnostic, Pharma, and MedTech
Value Based Care
• Pay for outcomes
• Diagnostic + Therapeutic + biometric
documented outcome
• Adherence and compliance
• Reduce unnecessary hospitalizations
• Better, faster, cheaper clinical trials

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© 2015 Qualcomm Life. All rights reserved. 9
INTEROPERABLE DEVICE DATA CAPTURE ON A COMMON PLATFORM
Patient EngagementCare CoordinationIntensive Monitoring
IoMT from Hosptial to Home and All Points Between
Point of Care
Validation of Vitals
FDA Cleared Device
& Sensors
Single Device
Platform
Secure Pt. & Data
Association
Unified Analytics
& Alerting
Acute Hospital
Sub-Acute: Clinic, Long Term
Care, Skilled Nursing Facilities Home, Wellness, Wired & Wireless
Analytics Physical Alerts

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“Mobilisation” of Clinical Trials (Lessons Learned)
10
BYOD
Mobile Devices Healthcare Device Connectivity
Mobile Operating Systems
Remote Device Management
MCD/HCD Testing & Validation
Mobile Broadband Service
Connectivity Standards
Mobile Operations
Relying on consumer’s own smartphone & tablet
introduces many uncontrollable variables that need
workaround processes. The first step is to
understand the risk areas.
Understanding and being able to drive the
mobile device landscape which is the
endpoint that all these devices connect and
drives the experience the patient has
Making previously disconnected healthcare
devices wireless and making them
interoperate well together
Wirelessly managing medical and mobile
devices in the field with upgrades and
improvements without impacting patient
experience
Mature processes and infrastructure to
manage issues proactively before
customers notice them and when
customer-impacting issues occur, manage
through them effectively
Leading the industry to work
with medical device and mobile
device industry to drive
standards towards a more
interoperable and seamless
future
Managing and monitoring wireless carriers globally within an integrated experience to ensure
a seamless experience with security, reliability and without data loss
Testing all the thousands of combinations of
medical devices against thousands of
combinations of each mobile make, model
and OS version to ensure “it just works”
Managing the fragmentation of Android with
IOS & Android rapid upgrade cycles within
slower medical device cycles and meet
medical device quality standardsUniquely driving the mobile
device world and the
connected health world to
enable both worlds to work
together for the benefit of
patients and trials

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Backup Examples
© 2014 Qualcomm Life. All rights reserved. 11

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Medtech Example: Remote Chronic Care Management
© 2015 Qualcomm Life. All rights reserved. 12
• Create a frictionless solution to facilitate increased home
testing for improved Warfarin therapy management
- Added convenience for patient
- Informed interventions for provide
- Reduce unnecessary hospitalizations and complications
resulting from sub-optimal Warfarin therapy management
- >500,000 patients on Roche Coaguchek today
Roche Diagnostics
“At its core, point-of-care diagnostics have a singular and elegant focus: to provide patients and their physicians with
reliable, medically-relevant results when and where they need them.”1
1 Dr. Alan Wright, Chief Medical Officer, Roche Diagnostics

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AirView Care Management’s connected respiratory patient
management platform, leverages the 2net
and HealthyCircles Platforms
Dynamic tracking of respiratory rate,
tidal volume, minute ventilation, usage
Aggregation and visualization of data for
exception management
Wireless capture and transmission of
custom Care Management checklist
© 2015 Qualcomm Life. All rights reserved.

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Clinical Trials
Pharma Example: Digital Medicines
14
One pharma customer, millions of units in addressable market with common solution
© 2015 Qualcomm Life. All rights reserved.
Heart Failure
Asthma
• Same Breezhaler platform
• 2018 Asthma drug planned
• >100M devices
• 10-20M connected
• Entresto Heart Failure Drug
• Companion diagnostic + nurse
monitoring service
• Trials of the future program
• >500k patients on Novartis
trials at any time
• 100k new patients each year
Chief Executive Joe Jimenez
said Thursday Novartis was
“looking hard” at going to
insurers with add-on services
intended to further improve
outcomes for patients on
Entresto. He said this could
involve providing a device that
allowed doctors to monitor
patients remotely so they could
pick up on early signs of
deterioration. “If you had a
remote patient-monitoring
device that the patient could
use in their home together
with Entresto, we could make
an even more serious dent in
hospitalization,” he said in an
interview with The Wall Street
Journal.
COPD
• Breezhaler platform
• 4 COPD drugs
• >100M devices
• 10-20M connected

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Walgreens Balance Rewards for healthy choices™ program
integrated with 2net rewards patients for being engaged in their
health care
15© 2015 Qualcomm Life. All rights reserved.

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© 2014 Qualcomm Life. All rights reserved. 16