dr karim

1. The Lymphatic System & Lymphoid Organs and Tissues
Assoc.Prof. Dr. Karim Al-Jashamy
MSU/IMS 2010

2. Introduction
– Components
• Lymph is the fluid
• Vessels – lymphatics
• Structures & organs
– Functions
• Return tissue fluid to the bloodstream
• Transport fats from the digestive tract to the
bloodstream
• Surveillance & defense

3. Lymphatics
– Originate as lymph capillaries
– Capillaries unite to form larger vessels
• Resemble veins in structure
• Connect to lymph nodes at various intervals
– Lymphatics ultimately deliver lymph into 2
main channels
• Right lymphatic duct
– Drains right side of head & neck, right arm, right thorax
– Empties into the right subclavian vein
• Thoracic duct
– Drains the rest of the body
– Empties into the left subclavian vein

4. Main Channels of Lymphatics

5. Lymphatic System: Overview
• ������ Consists of two semi-independent parts:
• ������ A network of lymphatic vessels
• ������ Lymphoid tissues and organs scattered
throughout the body
• ������ Returns interstitial fluid and leaked plasma
proteins back to the blood
• ������ Lymph – interstitial fluid once it has entered
• lymphatic vessels

7. Lymphatic System: Overview

9. Lymphatic Vessels
• ������ One-way system, lymph flows toward the
heart
• ������ Lymph vessels include:
 Microscopic, permeable, blind-ended capillaries
 Lymphatic collecting vessels
Trunks and ducts

10. Lymphatic Capillaries
������ Similar to blood capillaries,
with modifications:
������ Very permeable
������ Loosely joined endothelial
minivalves
������ Withstand interstitial pressure
and remain open
������ The minivalves function as one-
way gates that:
 Allow interstitial fluid to enter
lymph capillaries
Do not allow lymph to escape
from the capillaries

11. Lymphatic Capillaries
During inflammation, lymph
capillaries can
absorb:
������ Cell debris
������ Pathogens
������ Cancer cells
������ Cells in the lymph nodes
cleanse and “examine”
this debris
 Lacteals – specialized lymph capillaries present in
intestinal mucosa.
 Absorb digested fat and deliver chyle to blood of the partial
blood vessels

12. Lymphatic Collecting Vessels
Have the same three tunics as
veins
������ Have thinner walls, with more
internal valves
������ Anastomose more frequently
������ Collecting vessels in the skin
travel with
superficial veins
������ Deep vessels travel with
arteries
������ Nutrients are supplied from
branching vasa vasorum

15. Lymphatic Trunks
������ Lymphatic trunks are
formed by the union of the
largest collecting ducts
������ Major trunks include:
������ Paired lumbar,
bronchomediastinal,
subclavian, and jugular
trunks
������ A single intestinal trunk

16. Lymph is delivered into one of two large trunks
������ Right lymphatic duct – drains the right upper
arm and the right side of the head and thorax
������ Thoracic duct – arises from the cisterna chyli
and drains the rest of the body

17. Lymphatic Trunks

18. Lymph Transport
������ The lymphatic system lacks a
pumping organ
������ Vessels are low-pressure conduits
������ Uses the same methods as veins
to propel lymph:
Pulsations of
nearby arteries.
 Contractions of
smooth muscle in the
walls of the
lymphatics

19. Lymphoid Cells
Lymphocytes are the main cells involved in the
immune response
������ Two main varieties:
������ T cells
������ B cells

20. Lymphocytes
T cells and B cells protect the body against
Antigens
������ Antigen – anything the body perceives as foreign
������ Bacteria and their toxins; viruses
������ Mismatched RBCs or cancer cells

21. Lymphocytes
T cells
������ Manage the immune
response
������ Attack and destroy foreign
cells
B cells
������ Produce plasma cells,
which secrete antibodies
������ Antibodies immobilize
antigens

22. Other Lymphoid Cells
Macrophages – phagocytes foreign substances
and help activate T cell

23. Dendritic cells – spiny-looking cells with
functions similar to macrophages

24. Reticular cells – fibroblast–like cells that produce a stroma, or
network, that supports other cell types in lymphoid organs