1. Comparative Opioid Pharmacology

7. Morphine The prototypical opioid

9. Simulation of Morphine Time Course Dahan et al. Anesthesiology. 2004 Nov;101(5):1201-9.

10. Fentanyl The ever morphing molecule

12. How we think of fentanyl: (small part of the market)

13. Fentanyl morph 1: Duragesic

14. Fentanyl morph 2: Actiq

15. Fentanyl morph 3: E-trans fentanyl Viscusi et al, JAMA 2004 291:1333

16. Fentanyl morph 4: Inhaled liposomal fentanyl Hung et al, Anesthesiology 1995 83:277-84

17. Fentanyl morph 5: Inhaled fentanyl aerosol Mather et al, Br J Clin Pharmacol 1998 46:37

18. Fentanyl morph 6: Effervescent Fentanyl (OraVescent) Pather et al, http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=5

19. Sufentanil Newly morphing molecule

21. Sufentanil morph 1: Implantable sufentanil delivery http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=115

23. Hydromorphone A better morphine

27. Methadone The Under-Utilized Opioid

29. Fundamental PK/PD Parameters

30. Comparative Opioid PK

31. Comparative Opioid PK

32. Comparative Onset of Opioid Drug Effect

33. Context Sensitive Half Time

34. 50% Effect Site Decrement Time

35. 20% Effect Site Decrement Time

36. Rise to Steady State

37. Relative Potency

38. 50  g fentanyl at 10 minutes

39. 50  g/hour fentanyl at 2 hours

40.  Opioid Receptor

44. MOR-1 gene splice variants (gene=OPRM) Gavril Pasternak, http://www.mskcc.org/mskcc/html/11384.cfm

45. Antisense lowers morphine analgesia (no effect on m6g) Gavril Pasternak, Life Sciences 2001:68, 2213

46. Antisense lowers m6g analgesia (no effect on morphine) Gavril Pasternak, Life Sciences 2001:68, 2213

49. “ Power corrupts, PowerPoint corrupts absolutely” dr shabeel pn