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1  sur  201
January 2014
(MRCP 1)
BY
Dr. Sherif Badrawy
BADRAWY notes MRCP
A very common SE of
Ciclosporin Rx ? ( and all
Calcineurin inhibitors)
1a
BADRAWY notes MRCP
Tremor
a better choice than
thrombocytopenia
1b
BADRAWY notes MRCP
Infertile woman with
proliferative endometrium
indicates ?
2a
BADRAWY notes MRCP
Anovulation
secretory endometrium is the
hallmark of ovulation.
2b
BADRAWY notes MRCP
Drugs commonly cause
extrapyramidal SEs ?
3a
BADRAWY notes MRCP
Conventional
antipsychotics
Not Atypical antipsychotics,
Not TCA
3b
BADRAWY notes MRCP
On standing for ≥ 1 minute,
physiological change ?
4a
BADRAWY notes MRCP
Decreased UOP
↓ SBP is immediately after standing
& only transient
COP , HR , Peripheral vascular
resistance all increase.
4b
BADRAWY notes MRCP
64 y ♀ Osteoporosis lumbar
spine (T score - 2.6,long term
inhaled CST), Rx ?
5a
BADRAWY notes MRCP
Alendronate ➜ 1st line Rx
a better choice than Denosumab ( a
rank ligand inhibitor given for 6
months SC injection, limited use dt
cost)
5b
BADRAWY notes MRCP
A pt é Ankylosing Spondylitis
(sacroiliac & back pain 8
months,limited lat. flexion & chest
expansion, sacroilitis in x ray, ↑
ESR) + failed Rx é 2 NSAIDS, Rx ?
6a
BADRAWY notes MRCP
Etanrecept
Anti -TNF recommended
after failed 2 NSAIDS , ( a
better choice than
Methotrexate)
6b
BADRAWY notes MRCP
A pt é Porphyrea Cutanea Tarda
(hyperpigmentation ,hypertrichosis,
blistering scarring eruptions in
dorsum of hand,worsen in summer,
alcoholic pt) , Dx (IN THE CLINIC)
by ?
7a
BADRAWY notes MRCP
Check urine é UV light
pink fluorescence under Wood's
lamp
for the CLINIC sitting this is a better
choice than urine porphyrins &
serum porphyrins.
7b
BADRAWY notes MRCP
A pt é truncal obesity, insulin
resistance, dyslipidemia ,
what do you expect more to
see ?
8a
BADRAWY notes MRCP
HTN
to complete the Dx of
Meabolic syndrome.
8b
BADRAWY notes MRCP
A helminth é a symptomatic
travel through the lung & the
adult worm resides in the
intestine ?
9a
BADRAWY notes MRCP
Ascaris lumbricoids
9b
BADRAWY notes MRCP
A pt é Essential Tremors (low
amplitude tremors, FH of
father affection , head
nodding, no bradykinesia, no
rigidity) , Rx ?
1 a
BADRAWY notes MRCP
Propranolol
Primidone also may be used.
1 b
BADRAWY notes MRCP
A 30 ♂ pt é psychological instability
(fired from job,custody dispute for
his children, Hx of episodes of
breathlessness when adolescent) c/o
of blindness inspite of normal
medical & neuro. examination, what
psychiatric Dx ?
11a
BADRAWY notes MRCP
Conversion Disorder
neurological symptoms ( ex.
Blindness, Deafness, loss of feelings
& physical immobility) with normal
examination
Rx by CBT (Cognitive Behavioral
Therapy).
11b
BADRAWY notes MRCP
A pt é Dermatitis
Herpitiformis with skin
biopsy, Igs to be found ?
12a
BADRAWY notes MRCP
IgA
present in dermal papillae ,
revealed on immunostaining.
Rx by Dapsone & Gluten free
diet
12b
BADRAWY notes MRCP
Buspirone acts on which
receptors ?
13a
BADRAWY notes MRCP
Serotonin receptors
5HT1A receptors, Short term Rx of
anxiety, effect may be delayed up to
2 wks , no dependance or abuse
potential.
13b
BADRAWY notes MRCP
a ♀ not affected by cystic fibrosis (
normal CXR) with a sister died by
the disease wants to calculate her
risk of having a child with cystic
fibrosis ( the carrier frequency in
population is 1 in 25) ?
14a
BADRAWY notes MRCP
1 in 150
this ♀ risk is 2 in 3 to be a carrier (as she's not
affected) + the partner from the population with
the risk of 1 in 23 + the chance of having affected
child if both are carriers is 1 in 4 ➜ overall
chance is 2/3 x 1/25 x 1/4 = 1/150.
the key to answer this is that in AR conditions the
risk of being a carrier is 2/3 not 2/4 (i.e 1/2) as
she's not affected.
14b
BADRAWY notes MRCP
A pt é Primary biliary cirrhosis (
♀,middle
age,jaundice,hepatosplenomegaly,FH),
Dx Abs ?
15a
BADRAWY notes MRCP
Anti-Mitochondrial Abs
against the components of pyruvate
dehydrogenase complex (E2 binding
protein & E3 binding protein)
appears long before Sx & before liver
function abnormalities.
15b
BADRAWY notes MRCP
Autosomal Dominant +
Severe mental retardation in
50% + benign growths in
various body parts ?
16a
BADRAWY notes MRCP
Tuberous Sclerosis
16b
BADRAWY notes MRCP
a young ♀ pt é depression ,
Chronic liver disease Ss,
Golden yellow ring at iris
periphery both eyes + low
serum copper, Dx ?
17a
BADRAWY notes MRCP
Wilson's Disease
defect in incorporating copper into
ceruloplasmin / Kayser Fleischer
ring almost always present / Rx by
Penicillamine
17b
BADRAWY notes MRCP
A pt é HOCM (arrested during a
rugby match & died + postmortem
biopsy ➜ LV & asymmetric septal
hypertrophy) , underlying pathology
?
18a
BADRAWY notes MRCP
Beta myosin heavy chain
mutation
a better choice than troponin
mutation (also occur in
HOCM)
18b
BADRAWY notes MRCP
Chronic Hepatitis B , ↑ risk
of ?
19a
BADRAWY notes MRCP
HCC
≅ 100 fold ↑ risk
19b
BADRAWY notes MRCP
Hypoglossal nerve paralysis
Lt side, outcome ?
2 a
BADRAWY notes MRCP
All intrinsic muscles of the Lt side
tongue are paralysed
supplies all ms of the tongue , none
of the palate / only motor, no
sensory.
2 b
BADRAWY notes MRCP
Primary Sclerosing
Cholangitis, correct statment
?
21a
BADRAWY notes MRCP
Cholangiocarcinoma occurs in ≅
20% of pts
(75 % associated with IBD / Age of
onset is 40 y / Men 70 % /
associated with HLA A1-B8- DR3)
21b
BADRAWY notes MRCP
A 79 y pt é dull abdominal pain
radiating to back, Anorexia,
cachexia, normo normo Anemia,
mild ↑ LFTs, ↑↑↑ bilirubin & ALP,
U/S abdomen ➜ bile duct
obstruction & epigastric mass , Dx ?
22a
BADRAWY notes MRCP
Pancreatic Carcinoma
back pain partially relieved by sitting
fwd / jaundice late & presenting
Symptom /± associated with
thrombophlebitis migrans / ±
thromboembolic phenomena / CA 19-
9
22b
BADRAWY notes MRCP
Causative factor for obesity in
the majority of pts ?
23a
BADRAWY notes MRCP
Energy intake in excess
of expenditure
Not genetic predisposition (
may be in some pts but not
the majority)
23b
BADRAWY notes MRCP
A pt é AIDS seroconversion (living
in Thailand, FEW WEEKS of night
sweat , diarrhea, lymphadenopathy
é -ve stool for cysts & ova), Dx ?
24a
BADRAWY notes MRCP
mycobacterium avium
intracellulare
Not CMV ( > acute onset of
presentation), Not cryptosporidium
( no ova or cysts in the stool)
24b
BADRAWY notes MRCP
A 32 y pt é paroxysmal SVT
,failed valsalva & carotid
sinus massage , Rx ?
25a
BADRAWY notes MRCP
IV Adenosine
a better option than
verapamil dt > rapid onset &
shorter duration of action.
25b
BADRAWY notes MRCP
The greatest absolute risk
reduction from the choices ?
26a
BADRAWY notes MRCP
15 % relative risk reduction vs a
placebo event rate of 3.5 %
absolute risk reduction = 3.5 x 0.15
= 0.525 % (other options are less)
26b
BADRAWY notes MRCP
A pt é LQT1 syndrome
collapsed dt VT & improved
after cardioversion, most
important initial intervention
to prevent recurrence ?
27a
BADRAWY notes MRCP
Atenolol
Not permenant pacemaker
if no response ➜ stellate
ganglionectomy.
ICD is 1st choices in LQT2 & LQT3
dt > incidence é sudden death.
27b
BADRAWY notes MRCP
A 79 y pt é dyspnea, facial
swelling , ? bronchial
neoplasm.. suspect SVC
obstruction, look for ?
28a
BADRAWY notes MRCP
Venous dilatation over the
anterior chest wall
SVC obst. is 70 % dt lung cancer,
oncological emmergency ➜ rapid Rx
é CST.
28b
BADRAWY notes MRCP
A correct statment regarding
ppt factors of DKA ?
29a
BADRAWY notes MRCP
Non compliance to Rx is the cause
in 25 % of cases
other ppt factors ➜ Infection 30-40
%,Chge insulin dose 13 %,Newly Dx
DM 10-20 %,MI <1 %.
29b
BADRAWY notes MRCP
What suggests Graves'
disease as the cause of
hyperthyroidism ?
3 a
BADRAWY notes MRCP
Pretibial myxoedema
a better choice than lid lag &
goitre.
3 b
BADRAWY notes MRCP
Should be considered in Rx
of Hemophilia A ?
31a
BADRAWY notes MRCP
Desmopressin may be useful
mild to moderate hemophilia
respond to desmopressin to cover
minor procedures such as tooth
extraction.
vWF levels are normal in hemophilia
A.
31b
BADRAWY notes MRCP
a young ♀ pt é Sx of
hypothyroidism postpartum,
Dx ?
32a
BADRAWY notes MRCP
Postpartum thyroiditis
Transient,self limiting, may
be associated é
hyperthyroidism.
Iodine deficiency is no rare.
32b
BADRAWY notes MRCP
Aquaporin 2 gene mutation
causes ?
33a
BADRAWY notes MRCP
Nephrogenic DI
33b
BADRAWY notes MRCP
A pt é RA diffusely red eye,
gritty, painful + preserved
visual acuity,Normal
schirmer test, Dx ?
34a
BADRAWY notes MRCP
Episcleritis
Not Scleritis. preserved visual acuity
points towards episcleritis + scleritis
associated é ≫ severe eye pain
worse at night & at moving the eye.
34b
BADRAWY notes MRCP
Associated with
Hyperkalemia ?
35a
BADRAWY notes MRCP
Ciclosporin
35b
BADRAWY notes MRCP
Adisonian Crisis é random
BS 3.4 mmol/l ,1st priority
Rx ?
36a
BADRAWY notes MRCP
Resuscitation é IV NS +
Hydrocortisone
Given simultaneously é immediate
priority to fluid resuscitation.
Not IV Hydrocortisone alone,not IV
glucose.
36b
BADRAWY notes MRCP
AIDS pt on HAART ➜
improved CD4 from 50 to
800 ,c/o reduced vision +
slight eye discomfort, Dx ?
37a
BADRAWY notes MRCP
Immune reconstitution
Uveitis
Not CMV retinitis,not
Toxoplasma (associated é
very low CD4 count)
37b
BADRAWY notes MRCP
Tamoxifen, a correct
statment ?
38a
BADRAWY notes MRCP
functions as a SERM
no need for PAP smear (no risk of
Cx canecr) / ↓ risk of IHD dt ↓ LDL
cholesterol / much ↓ effect on
estrogen receptor -ve tumors.
38b
BADRAWY notes MRCP
Recurrent Pneumonia +
pleural effusion,Quieckest
way to decide the need for
drainage ?
39a
BADRAWY notes MRCP
Pleural fluid pH
< 7.2 suggests parapneumonic
effusion requiring drainage
Not pleural fluid culture ➜ takes
sometime for a useful result.
39b
BADRAWY notes MRCP
HLA associated é RA ?
4 a
BADRAWY notes MRCP
HLA DR4
4 b
BADRAWY notes MRCP
A 24 y immigrant pt é several
months fever,wt loss,night
sweats,chronic cough ±
hemoptysis,calcified hilar LNs,
normo normo anemia, +ve AFB 6
months ago, Dx ?
41a
BADRAWY notes MRCP
Active pulmonary TB
41b
BADRAWY notes MRCP
Hepatorenal
Syndrome,mechanism of
craetinine deterioration ?
42a
BADRAWY notes MRCP
Renal vasoconstriction
definitive Rx is
transplantation.
42b
BADRAWY notes MRCP
A COPD pt é recurrent
exacerbations & hospital
admissions é FEV1 < 50 %,
Rx ?
43a
BADRAWY notes MRCP
Combination high dose
inhaled CST + LABA
43b
BADRAWY notes MRCP
A 24 y pt é dusky blue nodular rash
over shin, intermittent diarrhea ±
blood,proctoscopy ➜ moderate
rectal inflammation + normo normo
anemia + ↑ CRP , Dx ?
44a
BADRAWY notes MRCP
Ulcerative Colitis
a better choice than Crohn's disease
as predominant lower GI Sx é
proctitis are > suggestive of
ulcerative colitis.
44b
BADRAWY notes MRCP
A 45 y pt contact tracing program
referral dt sitting beside a man later
found to be +ve in a flight to
pakistan,no Hx of TB, no BCG
vaccine, normal examination, next
step ?
45a
BADRAWY notes MRCP
Mantoux test
a very useful initial screening tool.
Not Chest X-ray (next step after
mantoux), Not prophylactic Anti-TB
Rx.
45b
BADRAWY notes MRCP
A 48 y pt blurring Lt eye, Angioid
streaks,macular edema,skin folds é
yellow striations & puckering in the
neck & flexor aspect of joints, Dx ?
46a
BADRAWY notes MRCP
Pseudoxanthoma
elasticum
Not Marfan's syndrome.
46b
BADRAWY notes MRCP
A 61 y pt DM, COPD on ↑ dose seretide
inhaler + multiple toe nail fungal
infections, Rx ?
47a
BADRAWY notes MRCP
Oral Terbinafine
Topical is ineffective in fungal nail
infection, oral Terbinafine is better
than oral Itraconazole esp. in a COPD
pt é possibility of macrolide Rx for
exacerbation ( ↑ risk of QT
prolongation in this combination).
47b
BADRAWY notes MRCP
Acquired lipodystrophy
(young ♀ pt, loss of fat
around the face & upper
body, creatinine 110), which
complement deficiency ?
48a
BADRAWY notes MRCP
C3
Acquired lipodystrophy ➜ no
metabolic abnormalities
Congenital lipodystrophy ➜
metabolic abnormalities.
48b
BADRAWY notes MRCP
A 12 y boy é gradually progressive
plaque on his buttock for 3 years
with crusting and induration at the
periphery and scarring at the centre
annular, Dx ?
49a
BADRAWY notes MRCP
Lupus vulgaris
Not Tinea corporis
A lesion with central scarring is suggestive
of lupus vulgaris
commonest manifestation of cutaneous
TB, slightly itchy, asymmetrical scaly
Tinea corporis has central clearing and an
advanced scaly raised edge
49b
BADRAWY notes MRCP
A pt é cirrhosis secondary to
hepatitis C, progressive
deterioration over 6 months, Hx of
IV heroin abuse & alcoholism,
weight loss and worsening ascites, ↑
alpha-fetoprotein,Dx ?
5 a
BADRAWY notes MRCP
HCC
definitive Dx by U/S folloed
by CT guided biopsy, Rx usu
palliative.
5 b
BADRAWY notes MRCP
a young ♀ é Sx of pulmonary
HTN (Exertional dyspnea,LL
oedema),best Ix to exclude
2ndry pulmonary HTN ?
51a
BADRAWY notes MRCP
CT pulmonary Angio
a better choice than ECHO &
V/Q scan
51b
BADRAWY notes MRCP
clinical phase-ll study in oncology,
testing a new chemotherapy in
patients with a malignant tumour
Which statistical test is most
appropriate to compare the survival
times?
52a
BADRAWY notes MRCP
Log-rank test
52b
BADRAWY notes MRCP
a young pt é aplastic anemia
(BM biopsy ↓ hematopoeitic
cells, fatty BM), most
effective long term Rx ?
53a
BADRAWY notes MRCP
Hematopoeitic stem cell
transplantation
a better choice than chemotherapy
Children & young adults ➜ BM
transplantation is 1st choice Rx of
severe aplastic anemia.
53b
BADRAWY notes MRCP
Anti-epileptic drug causing
SIADH (hyponatremia & ↓
plasma osmolality) ?
54a
BADRAWY notes MRCP
Carbamazepine
Dose related hyponatremia
54b
BADRAWY notes MRCP
an old pt not DM é Lt lateral
hip pain, ↑ é abduction
against resistance, Dx ?
55a
BADRAWY notes MRCP
Trochanteric bursitis
Not Osteoarthritis ( limitation with
the full range of movement + deeper
pain within the joint) / not iliopsoas
bursitis (medial pain over femoral
triangle).
55b
BADRAWY notes MRCP
a elderly DM pt é Hx of extensive
psoriasis, hot swollen Lt knee joint,
limited mobility, ↑ESR, WBCs,
Creatinine, knee x ray ➜
osteoarthritis with large effusion,
next best step ?
56a
BADRAWY notes MRCP
Orthopedic referral for aspiration
& washout.
a better choice than IV
Flucloxacilline ➜ Abiotics without
aspiration & washout of the joint
can cause permenant joint damage.
56b
BADRAWY notes MRCP
a middle age ♂ with wt loss,
night sweats,mild asthma,
Dyspnea,cough, nosebleed,
↑ESR, ↑Creatinine,cANCA
+ve, Dx ?
57a
BADRAWY notes MRCP
Wegener's
granulomatosis
Not churg strauss syndrome.
57b
BADRAWY notes MRCP
a 16 y ♀ é B/L renal cortical
scarring,Hx of recurrent UTIs with
antibiotis in childhood but no UTIs
since 5 y., HTN (180/104),
Creatinine 186 , how to prevent
further kidney damage ?
58a
BADRAWY notes MRCP
ACE Inhibitors
a better choice than Surgical re-insertion
of ureters
imaging + Hx of recurrent UTIs in
childhood ➜ Chronic reflux nephropathy.
∵ no recent UTIs ➜ recurrent infections
are over ➜ little benefit of Surgical re-
insertion of ureters.
58b
BADRAWY notes MRCP
An elderly pt é Polymyositis (
proximal ms weakness +
shoulder pain + ↑↑ CK) ,
initial Rx of choice ?
59a
BADRAWY notes MRCP
Prednisolone
screen for underlying
malignancy
59b
BADRAWY notes MRCP
Organism seen in the sputum
of HIV infected pt ?
6 a
BADRAWY notes MRCP
Cryptococcus
Not Cryptosporidium (causes
Diarrhea not pneumonia)
Dx of Cryptococcus by India Ink
stain, in Meningitis do Ag titre
Rx by IV Amphotrecin B or
Fluconazole.
6 b
BADRAWY notes MRCP
Hemophilia B mode of
inheritance ?
61a
BADRAWY notes MRCP
X-linked recessive
Also Hemophilia A.
61b
BADRAWY notes MRCP
trials a new drug for lowering lipid
levels.2 groups, one receiving the
drug and the other placebo. What is
the best statistical test for
comparing mean cholesterols
between the two groups?
62a
BADRAWY notes MRCP
Unpaired T test
62b
BADRAWY notes MRCP
For what metabolic process
Riboflavin is required ?
63a
BADRAWY notes MRCP
Hydrogen-transfer chain
in the mitochondria
63b
BADRAWY notes MRCP
An 58 pt Uncontrolled DM1 é 5
units bloot transfusion 2 wks earlier,
you want to do Hb A1c to assess
him,how long to wait to check Hb
A1c ?
64a
BADRAWY notes MRCP
6 months
Not 3 months
Lifespan of RBCs about 4 months & the
transfusion is large amount (5 units)
➜ wait 6 months before measuring
Hb A1c.
64b
BADRAWY notes MRCP
An elderly pt é large stroke ( Lt
hemiparesis, homonymous
hemianopia, left sided neglect,
receptive dysphasia, and poor left
sided co-ordination) what is most
likely to hinder further progress in
rehabilitation?
65a
BADRAWY notes MRCP
Receptive dysphasia
dt difficulties complying with
rehabilitation Rx
recovery from neglect is excellent +
function of the affected limb usu improve.
homonymous hemianopia will affect
driving but no effect on daily living.
65b
BADRAWY notes MRCP
a pt é Porphyria Cutanea tarda
(hyperpigmentation ,hypertrichosis,
blistering scarring eruptions in
dorsum of hand,worsen in summer,
alcoholic & smoker,urine & stool +ve
for porphyrins),most successful to ↓
severity ?
66a
BADRAWY notes MRCP
Avoidance of Alcohol
Not avoidance of smoking
66b
BADRAWY notes MRCP
a pt é CAP + reactivation of
Cold sore, Causative
Organism ?
67a
BADRAWY notes MRCP
Streptococcus
pneumoniae
67b
BADRAWY notes MRCP
a 43 y pt é frequent
Headaches worse in the
morning,HTN ,K 3.1,Normal
BMI, Creatinine 112, Test will
get the Dx ?
68a
BADRAWY notes MRCP
Renin Aldosterone ratio
Not Urinary metanephrines , Not 24
urinary free cortisol
Hypokalemia + HTN + Normal BMI
+ no Cushing's features ➜ Conn's
syndrome.
68b
BADRAWY notes MRCP
a 30 y pt é jaundice, anemia
& splenomegaly,
reticulocytosis + osmotic
fragility, Dx ?
69a
BADRAWY notes MRCP
Heriditary spherocytosis
Autosomal Dominant
69b
BADRAWY notes MRCP
Muscle control PIP joint
flexion ?
7 a
BADRAWY notes MRCP
Flexor Digitorum superficialis
Not Flexor Digitorum profundus ➜
flexion at wrist, metacarpophalangeal
& interphalangeal joints.
Lumbricals ➜ flexion at
metacarpophalangeal & extension at
interphalangeal joints.
7 b
BADRAWY notes MRCP
most important physiologic
mechanism that prevents
reflux ?
71a
BADRAWY notes MRCP
parasympathetic
stimulation of the lower
circular smooth ms fibers of
the oesophagus
No true anatomical sphincter
71b
BADRAWY notes MRCP
MOA of Allopurinol ?
72a
BADRAWY notes MRCP
Inhibits xanthine oxidase
Colchicine Inhibits microtubule
polymerization ➜ ↓ inflammatory
activity. Rasburicase is a recombinent
urate oxidase inhibitor ➜ ↓ tumor
lysis syndrome with chemotherapy.
72b
BADRAWY notes MRCP
a pt é GBS + desatting on
lying flat + unable to perform
spirometry ?
73a
BADRAWY notes MRCP
ITU review for
consideration of
ventilation
73b
BADRAWY notes MRCP
HF despite maximal medical
Rx, a decision for pacemaker
,type ?
74a
BADRAWY notes MRCP
biventricular pacemaker
Not Dual chamber
pacemaker
74b
BADRAWY notes MRCP
a 17 y ♀ é Collapse after
strenuous exercise,felt weak
and faint afterwards, father
died suddenly at a young age
,normal examination, Dx ?
75a
BADRAWY notes MRCP
Cardiac syncope
Not Seizures
MCC is HOCM but lack of physical
signs is against that.
Long QT syndrome & Brugada
syndrome are possibilities
75b
BADRAWY notes MRCP
Which is most consistent
with a diagnosis of Bell's
palsy?
76a
BADRAWY notes MRCP
Hyperacusis
Not Loss of sensation
loss of lacrimation in lesions before
the geniculate ganglion.
Loss of taste to the anterior 2/3 of
the tongue in severe cases.
76b
BADRAWY notes MRCP
a pt é Headache + 3rd nerve
palsy ,Dx ?
77a
BADRAWY notes MRCP
Posterior communicating
Artery aneurysm
77b
BADRAWY notes MRCP
a pt é CAP, most useful in
predicting outcome ?
78a
BADRAWY notes MRCP
Urea
( CURB 65)
78b
BADRAWY notes MRCP
CLL pt é recurrent infections
,Etiology ?
79a
BADRAWY notes MRCP
Immunoglobulin
deficiency
Not T cell dysfunction
79b
BADRAWY notes MRCP
DOCH to control BP in
pheochromocytoma ?
8 a
BADRAWY notes MRCP
Phenoxybenzamine
if going for surgery start it 7-
10 days before
8 b
BADRAWY notes MRCP
Long term prognosis of HSP
?
81a
BADRAWY notes MRCP
Complete recovery with no
long term sequelae
81b
BADRAWY notes MRCP
Route of Adrenaline
adminestration in
anaphylactic shock ?
82a
BADRAWY notes MRCP
Intramuscular
Not IV as Intramuscular is
the most predictable profile
on absorption & clinical
effect.
82b
BADRAWY notes MRCP
Post-needle stick injury from
a pt with known hepatitis C
+ve ?
83a
BADRAWY notes MRCP
Monthly hepatitis C PCR
83b
BADRAWY notes MRCP
Bullous impetigo with
systemic Sx (fever, ↑ WBCs,
↑CRP) , Rx ?
84a
BADRAWY notes MRCP
IV Co-Amoxiclav
a better choice than oral
flucloxacillin dt > range of
action.
84b
BADRAWY notes MRCP
Chronic alcoholic,Generalized weakness
+ tremors + hypokalemia +
hypocalcemia, Etiology ?
85a
BADRAWY notes MRCP
Hypomagnesemia
dt malnutrition and alcohol
related diuresis
85b
BADRAWY notes MRCP
the strongest pointer towards
a diagnosis of Type 1
diabetes?
86a
BADRAWY notes MRCP
Ketonuria
Not Anti-GAD antibodies
Single autoantibody +ve is not indicative
of a diagnosis of DM1
2 or 3 antibody positivity being a much
stronger pointer towards significant
autoimmune beta cell destruction
86b
BADRAWY notes MRCP
VF in a controlled
enviroment (CCU), Rx of
choice ?
87a
BADRAWY notes MRCP
Defibrillate
Not precordial thumb (only
give if defibrillator is
unavailable)
87b
BADRAWY notes MRCP
HIT, most common
complication ? (IgG Abs
against PF4- heparin coplex)
88a
BADRAWY notes MRCP
DVT
Not arterial thrombosis
88b
BADRAWY notes MRCP
Tirofiban, MOA ?
89a
BADRAWY notes MRCP
2b3a inhibitor
Platelet function returns to baseline
within eight hours after
discontinuation.
contraindicated in hepatic
dysfunction
89b
BADRAWY notes MRCP
Peanut allergy,correct
statment ?
9 a
BADRAWY notes MRCP
The wheal size resulting from the skin
prick test is an excellent predictor of a
positive food challenge to peanuts
The severity of the next allergic reaction
cannot be predicted by skin prick test or
specific lgE,depends on other factors
(amount consumed and intercurrent viral
infections).
9 b
BADRAWY notes MRCP
Wernicke's encephalopathy
(thiamine deficiency in
Alcoholic),what do you
expect to see ?
91a
BADRAWY notes MRCP
Nystagmus
a better choice than coma
Nystagmus is the commonest
eye sign in wernicke's
91b
BADRAWY notes MRCP
Pain in Rt Knee ,Sx of
Reactive Arthritis,Rt Knee
aspirate showed no
organisms, Rx ?
92a
BADRAWY notes MRCP
Intra-articular CST injection
a better choice than Diclofenac or
Doxycycline
Systemic NSAIDS are the mainstay of
Rx but in MONOARTHRITIS ➜
Intra-articular CST after ensuring -ve
aspirate from the joint is better.
92b
BADRAWY notes MRCP
a 23 ♂ pt é anal discharge +
dysuria + urethral smear ➜
intracellular diplococci, Dx ?
93a
BADRAWY notes MRCP
Neisseria Gonorrhea
93b
BADRAWY notes MRCP
Central Chest pain ECG
reveals Twave inversion in V5
and V6 finding on
angiography?
94a
BADRAWY notes MRCP
Critical stenosis of the left
circumOex artery
94b
BADRAWY notes MRCP
Acute Pericareditis, ECG
finding ?
95a
BADRAWY notes MRCP
PR depression
95b
BADRAWY notes MRCP
A 34-y ♀ non-smoker moderate
hypoxaemia,Lung function tests
normal lung volumes but a reduced
Tlco at 45%
PCO2 of 7.9 kPa ?
96a
BADRAWY notes MRCP
Pulmonary arteriovenous
malformation
right-to-left shunts, so reducing Tlco
values and provoking
hypoxaemia.Emphysema can cause ↓Tlco
but is usually associated with ↑residual
volume and would be unusual in a young
non-smoker.
96b
BADRAWY notes MRCP
A 72-y ♀ left total hip
replacement ,Routine Ix
(WBC 22.5, Lymphocytes 19)
most appropriate Rx ?
97a
BADRAWY notes MRCP
Go ahead with the surgery
but keep her under
haematology follow-up
Mostly CLL & doesn't require
Rx now
97b
BADRAWY notes MRCP
Lyme disease (tick bite 3
months ago + rash) with
sudden collapse,cause ?
98a
BADRAWY notes MRCP
AV heart block
98b
BADRAWY notes MRCP
Wegner's Granulomatosis,
findings in renal Biopsy ?
99a
BADRAWY notes MRCP
Necrotizing GN without
complement or Ig
deposition
99b
BADRAWY notes MRCP
A 16-y ♂ abdominal pain and
vomiting , ↓Power distally
ankle and knee reOexes
absent,sister has similar condition
+basophilic stippling +Urinary D-
ALA +ve, Dx ?
1 a
BADRAWY notes MRCP
Lead poisoning
Not Acute intermittent
porphyria (dt basophilic
stippling isn't in AIP)
1 b
BADRAWY notes MRCP

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January 2014 MRCP1

  • 1. January 2014 (MRCP 1) BY Dr. Sherif Badrawy BADRAWY notes MRCP
  • 2. A very common SE of Ciclosporin Rx ? ( and all Calcineurin inhibitors) 1a BADRAWY notes MRCP
  • 3. Tremor a better choice than thrombocytopenia 1b BADRAWY notes MRCP
  • 4. Infertile woman with proliferative endometrium indicates ? 2a BADRAWY notes MRCP
  • 5. Anovulation secretory endometrium is the hallmark of ovulation. 2b BADRAWY notes MRCP
  • 6. Drugs commonly cause extrapyramidal SEs ? 3a BADRAWY notes MRCP
  • 8. On standing for ≥ 1 minute, physiological change ? 4a BADRAWY notes MRCP
  • 9. Decreased UOP ↓ SBP is immediately after standing & only transient COP , HR , Peripheral vascular resistance all increase. 4b BADRAWY notes MRCP
  • 10. 64 y ♀ Osteoporosis lumbar spine (T score - 2.6,long term inhaled CST), Rx ? 5a BADRAWY notes MRCP
  • 11. Alendronate ➜ 1st line Rx a better choice than Denosumab ( a rank ligand inhibitor given for 6 months SC injection, limited use dt cost) 5b BADRAWY notes MRCP
  • 12. A pt é Ankylosing Spondylitis (sacroiliac & back pain 8 months,limited lat. flexion & chest expansion, sacroilitis in x ray, ↑ ESR) + failed Rx é 2 NSAIDS, Rx ? 6a BADRAWY notes MRCP
  • 13. Etanrecept Anti -TNF recommended after failed 2 NSAIDS , ( a better choice than Methotrexate) 6b BADRAWY notes MRCP
  • 14. A pt é Porphyrea Cutanea Tarda (hyperpigmentation ,hypertrichosis, blistering scarring eruptions in dorsum of hand,worsen in summer, alcoholic pt) , Dx (IN THE CLINIC) by ? 7a BADRAWY notes MRCP
  • 15. Check urine é UV light pink fluorescence under Wood's lamp for the CLINIC sitting this is a better choice than urine porphyrins & serum porphyrins. 7b BADRAWY notes MRCP
  • 16. A pt é truncal obesity, insulin resistance, dyslipidemia , what do you expect more to see ? 8a BADRAWY notes MRCP
  • 17. HTN to complete the Dx of Meabolic syndrome. 8b BADRAWY notes MRCP
  • 18. A helminth é a symptomatic travel through the lung & the adult worm resides in the intestine ? 9a BADRAWY notes MRCP
  • 20. A pt é Essential Tremors (low amplitude tremors, FH of father affection , head nodding, no bradykinesia, no rigidity) , Rx ? 1 a BADRAWY notes MRCP
  • 21. Propranolol Primidone also may be used. 1 b BADRAWY notes MRCP
  • 22. A 30 ♂ pt é psychological instability (fired from job,custody dispute for his children, Hx of episodes of breathlessness when adolescent) c/o of blindness inspite of normal medical & neuro. examination, what psychiatric Dx ? 11a BADRAWY notes MRCP
  • 23. Conversion Disorder neurological symptoms ( ex. Blindness, Deafness, loss of feelings & physical immobility) with normal examination Rx by CBT (Cognitive Behavioral Therapy). 11b BADRAWY notes MRCP
  • 24. A pt é Dermatitis Herpitiformis with skin biopsy, Igs to be found ? 12a BADRAWY notes MRCP
  • 25. IgA present in dermal papillae , revealed on immunostaining. Rx by Dapsone & Gluten free diet 12b BADRAWY notes MRCP
  • 26. Buspirone acts on which receptors ? 13a BADRAWY notes MRCP
  • 27. Serotonin receptors 5HT1A receptors, Short term Rx of anxiety, effect may be delayed up to 2 wks , no dependance or abuse potential. 13b BADRAWY notes MRCP
  • 28. a ♀ not affected by cystic fibrosis ( normal CXR) with a sister died by the disease wants to calculate her risk of having a child with cystic fibrosis ( the carrier frequency in population is 1 in 25) ? 14a BADRAWY notes MRCP
  • 29. 1 in 150 this ♀ risk is 2 in 3 to be a carrier (as she's not affected) + the partner from the population with the risk of 1 in 23 + the chance of having affected child if both are carriers is 1 in 4 ➜ overall chance is 2/3 x 1/25 x 1/4 = 1/150. the key to answer this is that in AR conditions the risk of being a carrier is 2/3 not 2/4 (i.e 1/2) as she's not affected. 14b BADRAWY notes MRCP
  • 30. A pt é Primary biliary cirrhosis ( ♀,middle age,jaundice,hepatosplenomegaly,FH), Dx Abs ? 15a BADRAWY notes MRCP
  • 31. Anti-Mitochondrial Abs against the components of pyruvate dehydrogenase complex (E2 binding protein & E3 binding protein) appears long before Sx & before liver function abnormalities. 15b BADRAWY notes MRCP
  • 32. Autosomal Dominant + Severe mental retardation in 50% + benign growths in various body parts ? 16a BADRAWY notes MRCP
  • 34. a young ♀ pt é depression , Chronic liver disease Ss, Golden yellow ring at iris periphery both eyes + low serum copper, Dx ? 17a BADRAWY notes MRCP
  • 35. Wilson's Disease defect in incorporating copper into ceruloplasmin / Kayser Fleischer ring almost always present / Rx by Penicillamine 17b BADRAWY notes MRCP
  • 36. A pt é HOCM (arrested during a rugby match & died + postmortem biopsy ➜ LV & asymmetric septal hypertrophy) , underlying pathology ? 18a BADRAWY notes MRCP
  • 37. Beta myosin heavy chain mutation a better choice than troponin mutation (also occur in HOCM) 18b BADRAWY notes MRCP
  • 38. Chronic Hepatitis B , ↑ risk of ? 19a BADRAWY notes MRCP
  • 39. HCC ≅ 100 fold ↑ risk 19b BADRAWY notes MRCP
  • 40. Hypoglossal nerve paralysis Lt side, outcome ? 2 a BADRAWY notes MRCP
  • 41. All intrinsic muscles of the Lt side tongue are paralysed supplies all ms of the tongue , none of the palate / only motor, no sensory. 2 b BADRAWY notes MRCP
  • 42. Primary Sclerosing Cholangitis, correct statment ? 21a BADRAWY notes MRCP
  • 43. Cholangiocarcinoma occurs in ≅ 20% of pts (75 % associated with IBD / Age of onset is 40 y / Men 70 % / associated with HLA A1-B8- DR3) 21b BADRAWY notes MRCP
  • 44. A 79 y pt é dull abdominal pain radiating to back, Anorexia, cachexia, normo normo Anemia, mild ↑ LFTs, ↑↑↑ bilirubin & ALP, U/S abdomen ➜ bile duct obstruction & epigastric mass , Dx ? 22a BADRAWY notes MRCP
  • 45. Pancreatic Carcinoma back pain partially relieved by sitting fwd / jaundice late & presenting Symptom /± associated with thrombophlebitis migrans / ± thromboembolic phenomena / CA 19- 9 22b BADRAWY notes MRCP
  • 46. Causative factor for obesity in the majority of pts ? 23a BADRAWY notes MRCP
  • 47. Energy intake in excess of expenditure Not genetic predisposition ( may be in some pts but not the majority) 23b BADRAWY notes MRCP
  • 48. A pt é AIDS seroconversion (living in Thailand, FEW WEEKS of night sweat , diarrhea, lymphadenopathy é -ve stool for cysts & ova), Dx ? 24a BADRAWY notes MRCP
  • 49. mycobacterium avium intracellulare Not CMV ( > acute onset of presentation), Not cryptosporidium ( no ova or cysts in the stool) 24b BADRAWY notes MRCP
  • 50. A 32 y pt é paroxysmal SVT ,failed valsalva & carotid sinus massage , Rx ? 25a BADRAWY notes MRCP
  • 51. IV Adenosine a better option than verapamil dt > rapid onset & shorter duration of action. 25b BADRAWY notes MRCP
  • 52. The greatest absolute risk reduction from the choices ? 26a BADRAWY notes MRCP
  • 53. 15 % relative risk reduction vs a placebo event rate of 3.5 % absolute risk reduction = 3.5 x 0.15 = 0.525 % (other options are less) 26b BADRAWY notes MRCP
  • 54. A pt é LQT1 syndrome collapsed dt VT & improved after cardioversion, most important initial intervention to prevent recurrence ? 27a BADRAWY notes MRCP
  • 55. Atenolol Not permenant pacemaker if no response ➜ stellate ganglionectomy. ICD is 1st choices in LQT2 & LQT3 dt > incidence é sudden death. 27b BADRAWY notes MRCP
  • 56. A 79 y pt é dyspnea, facial swelling , ? bronchial neoplasm.. suspect SVC obstruction, look for ? 28a BADRAWY notes MRCP
  • 57. Venous dilatation over the anterior chest wall SVC obst. is 70 % dt lung cancer, oncological emmergency ➜ rapid Rx é CST. 28b BADRAWY notes MRCP
  • 58. A correct statment regarding ppt factors of DKA ? 29a BADRAWY notes MRCP
  • 59. Non compliance to Rx is the cause in 25 % of cases other ppt factors ➜ Infection 30-40 %,Chge insulin dose 13 %,Newly Dx DM 10-20 %,MI <1 %. 29b BADRAWY notes MRCP
  • 60. What suggests Graves' disease as the cause of hyperthyroidism ? 3 a BADRAWY notes MRCP
  • 61. Pretibial myxoedema a better choice than lid lag & goitre. 3 b BADRAWY notes MRCP
  • 62. Should be considered in Rx of Hemophilia A ? 31a BADRAWY notes MRCP
  • 63. Desmopressin may be useful mild to moderate hemophilia respond to desmopressin to cover minor procedures such as tooth extraction. vWF levels are normal in hemophilia A. 31b BADRAWY notes MRCP
  • 64. a young ♀ pt é Sx of hypothyroidism postpartum, Dx ? 32a BADRAWY notes MRCP
  • 65. Postpartum thyroiditis Transient,self limiting, may be associated é hyperthyroidism. Iodine deficiency is no rare. 32b BADRAWY notes MRCP
  • 66. Aquaporin 2 gene mutation causes ? 33a BADRAWY notes MRCP
  • 68. A pt é RA diffusely red eye, gritty, painful + preserved visual acuity,Normal schirmer test, Dx ? 34a BADRAWY notes MRCP
  • 69. Episcleritis Not Scleritis. preserved visual acuity points towards episcleritis + scleritis associated é ≫ severe eye pain worse at night & at moving the eye. 34b BADRAWY notes MRCP
  • 72. Adisonian Crisis é random BS 3.4 mmol/l ,1st priority Rx ? 36a BADRAWY notes MRCP
  • 73. Resuscitation é IV NS + Hydrocortisone Given simultaneously é immediate priority to fluid resuscitation. Not IV Hydrocortisone alone,not IV glucose. 36b BADRAWY notes MRCP
  • 74. AIDS pt on HAART ➜ improved CD4 from 50 to 800 ,c/o reduced vision + slight eye discomfort, Dx ? 37a BADRAWY notes MRCP
  • 75. Immune reconstitution Uveitis Not CMV retinitis,not Toxoplasma (associated é very low CD4 count) 37b BADRAWY notes MRCP
  • 76. Tamoxifen, a correct statment ? 38a BADRAWY notes MRCP
  • 77. functions as a SERM no need for PAP smear (no risk of Cx canecr) / ↓ risk of IHD dt ↓ LDL cholesterol / much ↓ effect on estrogen receptor -ve tumors. 38b BADRAWY notes MRCP
  • 78. Recurrent Pneumonia + pleural effusion,Quieckest way to decide the need for drainage ? 39a BADRAWY notes MRCP
  • 79. Pleural fluid pH < 7.2 suggests parapneumonic effusion requiring drainage Not pleural fluid culture ➜ takes sometime for a useful result. 39b BADRAWY notes MRCP
  • 80. HLA associated é RA ? 4 a BADRAWY notes MRCP
  • 81. HLA DR4 4 b BADRAWY notes MRCP
  • 82. A 24 y immigrant pt é several months fever,wt loss,night sweats,chronic cough ± hemoptysis,calcified hilar LNs, normo normo anemia, +ve AFB 6 months ago, Dx ? 41a BADRAWY notes MRCP
  • 85. Renal vasoconstriction definitive Rx is transplantation. 42b BADRAWY notes MRCP
  • 86. A COPD pt é recurrent exacerbations & hospital admissions é FEV1 < 50 %, Rx ? 43a BADRAWY notes MRCP
  • 87. Combination high dose inhaled CST + LABA 43b BADRAWY notes MRCP
  • 88. A 24 y pt é dusky blue nodular rash over shin, intermittent diarrhea ± blood,proctoscopy ➜ moderate rectal inflammation + normo normo anemia + ↑ CRP , Dx ? 44a BADRAWY notes MRCP
  • 89. Ulcerative Colitis a better choice than Crohn's disease as predominant lower GI Sx é proctitis are > suggestive of ulcerative colitis. 44b BADRAWY notes MRCP
  • 90. A 45 y pt contact tracing program referral dt sitting beside a man later found to be +ve in a flight to pakistan,no Hx of TB, no BCG vaccine, normal examination, next step ? 45a BADRAWY notes MRCP
  • 91. Mantoux test a very useful initial screening tool. Not Chest X-ray (next step after mantoux), Not prophylactic Anti-TB Rx. 45b BADRAWY notes MRCP
  • 92. A 48 y pt blurring Lt eye, Angioid streaks,macular edema,skin folds é yellow striations & puckering in the neck & flexor aspect of joints, Dx ? 46a BADRAWY notes MRCP
  • 94. A 61 y pt DM, COPD on ↑ dose seretide inhaler + multiple toe nail fungal infections, Rx ? 47a BADRAWY notes MRCP
  • 95. Oral Terbinafine Topical is ineffective in fungal nail infection, oral Terbinafine is better than oral Itraconazole esp. in a COPD pt é possibility of macrolide Rx for exacerbation ( ↑ risk of QT prolongation in this combination). 47b BADRAWY notes MRCP
  • 96. Acquired lipodystrophy (young ♀ pt, loss of fat around the face & upper body, creatinine 110), which complement deficiency ? 48a BADRAWY notes MRCP
  • 97. C3 Acquired lipodystrophy ➜ no metabolic abnormalities Congenital lipodystrophy ➜ metabolic abnormalities. 48b BADRAWY notes MRCP
  • 98. A 12 y boy é gradually progressive plaque on his buttock for 3 years with crusting and induration at the periphery and scarring at the centre annular, Dx ? 49a BADRAWY notes MRCP
  • 99. Lupus vulgaris Not Tinea corporis A lesion with central scarring is suggestive of lupus vulgaris commonest manifestation of cutaneous TB, slightly itchy, asymmetrical scaly Tinea corporis has central clearing and an advanced scaly raised edge 49b BADRAWY notes MRCP
  • 100. A pt é cirrhosis secondary to hepatitis C, progressive deterioration over 6 months, Hx of IV heroin abuse & alcoholism, weight loss and worsening ascites, ↑ alpha-fetoprotein,Dx ? 5 a BADRAWY notes MRCP
  • 101. HCC definitive Dx by U/S folloed by CT guided biopsy, Rx usu palliative. 5 b BADRAWY notes MRCP
  • 102. a young ♀ é Sx of pulmonary HTN (Exertional dyspnea,LL oedema),best Ix to exclude 2ndry pulmonary HTN ? 51a BADRAWY notes MRCP
  • 103. CT pulmonary Angio a better choice than ECHO & V/Q scan 51b BADRAWY notes MRCP
  • 104. clinical phase-ll study in oncology, testing a new chemotherapy in patients with a malignant tumour Which statistical test is most appropriate to compare the survival times? 52a BADRAWY notes MRCP
  • 106. a young pt é aplastic anemia (BM biopsy ↓ hematopoeitic cells, fatty BM), most effective long term Rx ? 53a BADRAWY notes MRCP
  • 107. Hematopoeitic stem cell transplantation a better choice than chemotherapy Children & young adults ➜ BM transplantation is 1st choice Rx of severe aplastic anemia. 53b BADRAWY notes MRCP
  • 108. Anti-epileptic drug causing SIADH (hyponatremia & ↓ plasma osmolality) ? 54a BADRAWY notes MRCP
  • 110. an old pt not DM é Lt lateral hip pain, ↑ é abduction against resistance, Dx ? 55a BADRAWY notes MRCP
  • 111. Trochanteric bursitis Not Osteoarthritis ( limitation with the full range of movement + deeper pain within the joint) / not iliopsoas bursitis (medial pain over femoral triangle). 55b BADRAWY notes MRCP
  • 112. a elderly DM pt é Hx of extensive psoriasis, hot swollen Lt knee joint, limited mobility, ↑ESR, WBCs, Creatinine, knee x ray ➜ osteoarthritis with large effusion, next best step ? 56a BADRAWY notes MRCP
  • 113. Orthopedic referral for aspiration & washout. a better choice than IV Flucloxacilline ➜ Abiotics without aspiration & washout of the joint can cause permenant joint damage. 56b BADRAWY notes MRCP
  • 114. a middle age ♂ with wt loss, night sweats,mild asthma, Dyspnea,cough, nosebleed, ↑ESR, ↑Creatinine,cANCA +ve, Dx ? 57a BADRAWY notes MRCP
  • 115. Wegener's granulomatosis Not churg strauss syndrome. 57b BADRAWY notes MRCP
  • 116. a 16 y ♀ é B/L renal cortical scarring,Hx of recurrent UTIs with antibiotis in childhood but no UTIs since 5 y., HTN (180/104), Creatinine 186 , how to prevent further kidney damage ? 58a BADRAWY notes MRCP
  • 117. ACE Inhibitors a better choice than Surgical re-insertion of ureters imaging + Hx of recurrent UTIs in childhood ➜ Chronic reflux nephropathy. ∵ no recent UTIs ➜ recurrent infections are over ➜ little benefit of Surgical re- insertion of ureters. 58b BADRAWY notes MRCP
  • 118. An elderly pt é Polymyositis ( proximal ms weakness + shoulder pain + ↑↑ CK) , initial Rx of choice ? 59a BADRAWY notes MRCP
  • 120. Organism seen in the sputum of HIV infected pt ? 6 a BADRAWY notes MRCP
  • 121. Cryptococcus Not Cryptosporidium (causes Diarrhea not pneumonia) Dx of Cryptococcus by India Ink stain, in Meningitis do Ag titre Rx by IV Amphotrecin B or Fluconazole. 6 b BADRAWY notes MRCP
  • 122. Hemophilia B mode of inheritance ? 61a BADRAWY notes MRCP
  • 123. X-linked recessive Also Hemophilia A. 61b BADRAWY notes MRCP
  • 124. trials a new drug for lowering lipid levels.2 groups, one receiving the drug and the other placebo. What is the best statistical test for comparing mean cholesterols between the two groups? 62a BADRAWY notes MRCP
  • 126. For what metabolic process Riboflavin is required ? 63a BADRAWY notes MRCP
  • 127. Hydrogen-transfer chain in the mitochondria 63b BADRAWY notes MRCP
  • 128. An 58 pt Uncontrolled DM1 é 5 units bloot transfusion 2 wks earlier, you want to do Hb A1c to assess him,how long to wait to check Hb A1c ? 64a BADRAWY notes MRCP
  • 129. 6 months Not 3 months Lifespan of RBCs about 4 months & the transfusion is large amount (5 units) ➜ wait 6 months before measuring Hb A1c. 64b BADRAWY notes MRCP
  • 130. An elderly pt é large stroke ( Lt hemiparesis, homonymous hemianopia, left sided neglect, receptive dysphasia, and poor left sided co-ordination) what is most likely to hinder further progress in rehabilitation? 65a BADRAWY notes MRCP
  • 131. Receptive dysphasia dt difficulties complying with rehabilitation Rx recovery from neglect is excellent + function of the affected limb usu improve. homonymous hemianopia will affect driving but no effect on daily living. 65b BADRAWY notes MRCP
  • 132. a pt é Porphyria Cutanea tarda (hyperpigmentation ,hypertrichosis, blistering scarring eruptions in dorsum of hand,worsen in summer, alcoholic & smoker,urine & stool +ve for porphyrins),most successful to ↓ severity ? 66a BADRAWY notes MRCP
  • 133. Avoidance of Alcohol Not avoidance of smoking 66b BADRAWY notes MRCP
  • 134. a pt é CAP + reactivation of Cold sore, Causative Organism ? 67a BADRAWY notes MRCP
  • 136. a 43 y pt é frequent Headaches worse in the morning,HTN ,K 3.1,Normal BMI, Creatinine 112, Test will get the Dx ? 68a BADRAWY notes MRCP
  • 137. Renin Aldosterone ratio Not Urinary metanephrines , Not 24 urinary free cortisol Hypokalemia + HTN + Normal BMI + no Cushing's features ➜ Conn's syndrome. 68b BADRAWY notes MRCP
  • 138. a 30 y pt é jaundice, anemia & splenomegaly, reticulocytosis + osmotic fragility, Dx ? 69a BADRAWY notes MRCP
  • 140. Muscle control PIP joint flexion ? 7 a BADRAWY notes MRCP
  • 141. Flexor Digitorum superficialis Not Flexor Digitorum profundus ➜ flexion at wrist, metacarpophalangeal & interphalangeal joints. Lumbricals ➜ flexion at metacarpophalangeal & extension at interphalangeal joints. 7 b BADRAWY notes MRCP
  • 142. most important physiologic mechanism that prevents reflux ? 71a BADRAWY notes MRCP
  • 143. parasympathetic stimulation of the lower circular smooth ms fibers of the oesophagus No true anatomical sphincter 71b BADRAWY notes MRCP
  • 144. MOA of Allopurinol ? 72a BADRAWY notes MRCP
  • 145. Inhibits xanthine oxidase Colchicine Inhibits microtubule polymerization ➜ ↓ inflammatory activity. Rasburicase is a recombinent urate oxidase inhibitor ➜ ↓ tumor lysis syndrome with chemotherapy. 72b BADRAWY notes MRCP
  • 146. a pt é GBS + desatting on lying flat + unable to perform spirometry ? 73a BADRAWY notes MRCP
  • 147. ITU review for consideration of ventilation 73b BADRAWY notes MRCP
  • 148. HF despite maximal medical Rx, a decision for pacemaker ,type ? 74a BADRAWY notes MRCP
  • 149. biventricular pacemaker Not Dual chamber pacemaker 74b BADRAWY notes MRCP
  • 150. a 17 y ♀ é Collapse after strenuous exercise,felt weak and faint afterwards, father died suddenly at a young age ,normal examination, Dx ? 75a BADRAWY notes MRCP
  • 151. Cardiac syncope Not Seizures MCC is HOCM but lack of physical signs is against that. Long QT syndrome & Brugada syndrome are possibilities 75b BADRAWY notes MRCP
  • 152. Which is most consistent with a diagnosis of Bell's palsy? 76a BADRAWY notes MRCP
  • 153. Hyperacusis Not Loss of sensation loss of lacrimation in lesions before the geniculate ganglion. Loss of taste to the anterior 2/3 of the tongue in severe cases. 76b BADRAWY notes MRCP
  • 154. a pt é Headache + 3rd nerve palsy ,Dx ? 77a BADRAWY notes MRCP
  • 156. a pt é CAP, most useful in predicting outcome ? 78a BADRAWY notes MRCP
  • 158. CLL pt é recurrent infections ,Etiology ? 79a BADRAWY notes MRCP
  • 159. Immunoglobulin deficiency Not T cell dysfunction 79b BADRAWY notes MRCP
  • 160. DOCH to control BP in pheochromocytoma ? 8 a BADRAWY notes MRCP
  • 161. Phenoxybenzamine if going for surgery start it 7- 10 days before 8 b BADRAWY notes MRCP
  • 162. Long term prognosis of HSP ? 81a BADRAWY notes MRCP
  • 163. Complete recovery with no long term sequelae 81b BADRAWY notes MRCP
  • 164. Route of Adrenaline adminestration in anaphylactic shock ? 82a BADRAWY notes MRCP
  • 165. Intramuscular Not IV as Intramuscular is the most predictable profile on absorption & clinical effect. 82b BADRAWY notes MRCP
  • 166. Post-needle stick injury from a pt with known hepatitis C +ve ? 83a BADRAWY notes MRCP
  • 167. Monthly hepatitis C PCR 83b BADRAWY notes MRCP
  • 168. Bullous impetigo with systemic Sx (fever, ↑ WBCs, ↑CRP) , Rx ? 84a BADRAWY notes MRCP
  • 169. IV Co-Amoxiclav a better choice than oral flucloxacillin dt > range of action. 84b BADRAWY notes MRCP
  • 170. Chronic alcoholic,Generalized weakness + tremors + hypokalemia + hypocalcemia, Etiology ? 85a BADRAWY notes MRCP
  • 171. Hypomagnesemia dt malnutrition and alcohol related diuresis 85b BADRAWY notes MRCP
  • 172. the strongest pointer towards a diagnosis of Type 1 diabetes? 86a BADRAWY notes MRCP
  • 173. Ketonuria Not Anti-GAD antibodies Single autoantibody +ve is not indicative of a diagnosis of DM1 2 or 3 antibody positivity being a much stronger pointer towards significant autoimmune beta cell destruction 86b BADRAWY notes MRCP
  • 174. VF in a controlled enviroment (CCU), Rx of choice ? 87a BADRAWY notes MRCP
  • 175. Defibrillate Not precordial thumb (only give if defibrillator is unavailable) 87b BADRAWY notes MRCP
  • 176. HIT, most common complication ? (IgG Abs against PF4- heparin coplex) 88a BADRAWY notes MRCP
  • 179. 2b3a inhibitor Platelet function returns to baseline within eight hours after discontinuation. contraindicated in hepatic dysfunction 89b BADRAWY notes MRCP
  • 180. Peanut allergy,correct statment ? 9 a BADRAWY notes MRCP
  • 181. The wheal size resulting from the skin prick test is an excellent predictor of a positive food challenge to peanuts The severity of the next allergic reaction cannot be predicted by skin prick test or specific lgE,depends on other factors (amount consumed and intercurrent viral infections). 9 b BADRAWY notes MRCP
  • 182. Wernicke's encephalopathy (thiamine deficiency in Alcoholic),what do you expect to see ? 91a BADRAWY notes MRCP
  • 183. Nystagmus a better choice than coma Nystagmus is the commonest eye sign in wernicke's 91b BADRAWY notes MRCP
  • 184. Pain in Rt Knee ,Sx of Reactive Arthritis,Rt Knee aspirate showed no organisms, Rx ? 92a BADRAWY notes MRCP
  • 185. Intra-articular CST injection a better choice than Diclofenac or Doxycycline Systemic NSAIDS are the mainstay of Rx but in MONOARTHRITIS ➜ Intra-articular CST after ensuring -ve aspirate from the joint is better. 92b BADRAWY notes MRCP
  • 186. a 23 ♂ pt é anal discharge + dysuria + urethral smear ➜ intracellular diplococci, Dx ? 93a BADRAWY notes MRCP
  • 188. Central Chest pain ECG reveals Twave inversion in V5 and V6 finding on angiography? 94a BADRAWY notes MRCP
  • 189. Critical stenosis of the left circumOex artery 94b BADRAWY notes MRCP
  • 190. Acute Pericareditis, ECG finding ? 95a BADRAWY notes MRCP
  • 192. A 34-y ♀ non-smoker moderate hypoxaemia,Lung function tests normal lung volumes but a reduced Tlco at 45% PCO2 of 7.9 kPa ? 96a BADRAWY notes MRCP
  • 193. Pulmonary arteriovenous malformation right-to-left shunts, so reducing Tlco values and provoking hypoxaemia.Emphysema can cause ↓Tlco but is usually associated with ↑residual volume and would be unusual in a young non-smoker. 96b BADRAWY notes MRCP
  • 194. A 72-y ♀ left total hip replacement ,Routine Ix (WBC 22.5, Lymphocytes 19) most appropriate Rx ? 97a BADRAWY notes MRCP
  • 195. Go ahead with the surgery but keep her under haematology follow-up Mostly CLL & doesn't require Rx now 97b BADRAWY notes MRCP
  • 196. Lyme disease (tick bite 3 months ago + rash) with sudden collapse,cause ? 98a BADRAWY notes MRCP
  • 198. Wegner's Granulomatosis, findings in renal Biopsy ? 99a BADRAWY notes MRCP
  • 199. Necrotizing GN without complement or Ig deposition 99b BADRAWY notes MRCP
  • 200. A 16-y ♂ abdominal pain and vomiting , ↓Power distally ankle and knee reOexes absent,sister has similar condition +basophilic stippling +Urinary D- ALA +ve, Dx ? 1 a BADRAWY notes MRCP
  • 201. Lead poisoning Not Acute intermittent porphyria (dt basophilic stippling isn't in AIP) 1 b BADRAWY notes MRCP