This document contains notes from Dr. Sherif Badrawy's MRCP examination. It includes multiple choice questions on various medical topics, with the correct answer provided for each. The notes cover areas such as rheumatology, endocrinology, hepatology, infectious diseases, cardiology and respiratory medicine. For each question, the rationale for the correct answer over other choices is also included to help explain the clinical reasoning.
8. On standing for ≥ 1 minute,
physiological change ?
4a
BADRAWY notes MRCP
9. Decreased UOP
↓ SBP is immediately after standing
& only transient
COP , HR , Peripheral vascular
resistance all increase.
4b
BADRAWY notes MRCP
10. 64 y ♀ Osteoporosis lumbar
spine (T score - 2.6,long term
inhaled CST), Rx ?
5a
BADRAWY notes MRCP
11. Alendronate ➜ 1st line Rx
a better choice than Denosumab ( a
rank ligand inhibitor given for 6
months SC injection, limited use dt
cost)
5b
BADRAWY notes MRCP
12. A pt é Ankylosing Spondylitis
(sacroiliac & back pain 8
months,limited lat. flexion & chest
expansion, sacroilitis in x ray, ↑
ESR) + failed Rx é 2 NSAIDS, Rx ?
6a
BADRAWY notes MRCP
14. A pt é Porphyrea Cutanea Tarda
(hyperpigmentation ,hypertrichosis,
blistering scarring eruptions in
dorsum of hand,worsen in summer,
alcoholic pt) , Dx (IN THE CLINIC)
by ?
7a
BADRAWY notes MRCP
15. Check urine é UV light
pink fluorescence under Wood's
lamp
for the CLINIC sitting this is a better
choice than urine porphyrins &
serum porphyrins.
7b
BADRAWY notes MRCP
16. A pt é truncal obesity, insulin
resistance, dyslipidemia ,
what do you expect more to
see ?
8a
BADRAWY notes MRCP
20. A pt é Essential Tremors (low
amplitude tremors, FH of
father affection , head
nodding, no bradykinesia, no
rigidity) , Rx ?
1 a
BADRAWY notes MRCP
22. A 30 ♂ pt é psychological instability
(fired from job,custody dispute for
his children, Hx of episodes of
breathlessness when adolescent) c/o
of blindness inspite of normal
medical & neuro. examination, what
psychiatric Dx ?
11a
BADRAWY notes MRCP
23. Conversion Disorder
neurological symptoms ( ex.
Blindness, Deafness, loss of feelings
& physical immobility) with normal
examination
Rx by CBT (Cognitive Behavioral
Therapy).
11b
BADRAWY notes MRCP
24. A pt é Dermatitis
Herpitiformis with skin
biopsy, Igs to be found ?
12a
BADRAWY notes MRCP
25. IgA
present in dermal papillae ,
revealed on immunostaining.
Rx by Dapsone & Gluten free
diet
12b
BADRAWY notes MRCP
27. Serotonin receptors
5HT1A receptors, Short term Rx of
anxiety, effect may be delayed up to
2 wks , no dependance or abuse
potential.
13b
BADRAWY notes MRCP
28. a ♀ not affected by cystic fibrosis (
normal CXR) with a sister died by
the disease wants to calculate her
risk of having a child with cystic
fibrosis ( the carrier frequency in
population is 1 in 25) ?
14a
BADRAWY notes MRCP
29. 1 in 150
this ♀ risk is 2 in 3 to be a carrier (as she's not
affected) + the partner from the population with
the risk of 1 in 23 + the chance of having affected
child if both are carriers is 1 in 4 ➜ overall
chance is 2/3 x 1/25 x 1/4 = 1/150.
the key to answer this is that in AR conditions the
risk of being a carrier is 2/3 not 2/4 (i.e 1/2) as
she's not affected.
14b
BADRAWY notes MRCP
30. A pt é Primary biliary cirrhosis (
♀,middle
age,jaundice,hepatosplenomegaly,FH),
Dx Abs ?
15a
BADRAWY notes MRCP
31. Anti-Mitochondrial Abs
against the components of pyruvate
dehydrogenase complex (E2 binding
protein & E3 binding protein)
appears long before Sx & before liver
function abnormalities.
15b
BADRAWY notes MRCP
32. Autosomal Dominant +
Severe mental retardation in
50% + benign growths in
various body parts ?
16a
BADRAWY notes MRCP
34. a young ♀ pt é depression ,
Chronic liver disease Ss,
Golden yellow ring at iris
periphery both eyes + low
serum copper, Dx ?
17a
BADRAWY notes MRCP
35. Wilson's Disease
defect in incorporating copper into
ceruloplasmin / Kayser Fleischer
ring almost always present / Rx by
Penicillamine
17b
BADRAWY notes MRCP
36. A pt é HOCM (arrested during a
rugby match & died + postmortem
biopsy ➜ LV & asymmetric septal
hypertrophy) , underlying pathology
?
18a
BADRAWY notes MRCP
37. Beta myosin heavy chain
mutation
a better choice than troponin
mutation (also occur in
HOCM)
18b
BADRAWY notes MRCP
41. All intrinsic muscles of the Lt side
tongue are paralysed
supplies all ms of the tongue , none
of the palate / only motor, no
sensory.
2 b
BADRAWY notes MRCP
43. Cholangiocarcinoma occurs in ≅
20% of pts
(75 % associated with IBD / Age of
onset is 40 y / Men 70 % /
associated with HLA A1-B8- DR3)
21b
BADRAWY notes MRCP
44. A 79 y pt é dull abdominal pain
radiating to back, Anorexia,
cachexia, normo normo Anemia,
mild ↑ LFTs, ↑↑↑ bilirubin & ALP,
U/S abdomen ➜ bile duct
obstruction & epigastric mass , Dx ?
22a
BADRAWY notes MRCP
45. Pancreatic Carcinoma
back pain partially relieved by sitting
fwd / jaundice late & presenting
Symptom /± associated with
thrombophlebitis migrans / ±
thromboembolic phenomena / CA 19-
9
22b
BADRAWY notes MRCP
47. Energy intake in excess
of expenditure
Not genetic predisposition (
may be in some pts but not
the majority)
23b
BADRAWY notes MRCP
48. A pt é AIDS seroconversion (living
in Thailand, FEW WEEKS of night
sweat , diarrhea, lymphadenopathy
é -ve stool for cysts & ova), Dx ?
24a
BADRAWY notes MRCP
53. 15 % relative risk reduction vs a
placebo event rate of 3.5 %
absolute risk reduction = 3.5 x 0.15
= 0.525 % (other options are less)
26b
BADRAWY notes MRCP
54. A pt é LQT1 syndrome
collapsed dt VT & improved
after cardioversion, most
important initial intervention
to prevent recurrence ?
27a
BADRAWY notes MRCP
55. Atenolol
Not permenant pacemaker
if no response ➜ stellate
ganglionectomy.
ICD is 1st choices in LQT2 & LQT3
dt > incidence é sudden death.
27b
BADRAWY notes MRCP
56. A 79 y pt é dyspnea, facial
swelling , ? bronchial
neoplasm.. suspect SVC
obstruction, look for ?
28a
BADRAWY notes MRCP
57. Venous dilatation over the
anterior chest wall
SVC obst. is 70 % dt lung cancer,
oncological emmergency ➜ rapid Rx
é CST.
28b
BADRAWY notes MRCP
58. A correct statment regarding
ppt factors of DKA ?
29a
BADRAWY notes MRCP
59. Non compliance to Rx is the cause
in 25 % of cases
other ppt factors ➜ Infection 30-40
%,Chge insulin dose 13 %,Newly Dx
DM 10-20 %,MI <1 %.
29b
BADRAWY notes MRCP
63. Desmopressin may be useful
mild to moderate hemophilia
respond to desmopressin to cover
minor procedures such as tooth
extraction.
vWF levels are normal in hemophilia
A.
31b
BADRAWY notes MRCP
64. a young ♀ pt é Sx of
hypothyroidism postpartum,
Dx ?
32a
BADRAWY notes MRCP
68. A pt é RA diffusely red eye,
gritty, painful + preserved
visual acuity,Normal
schirmer test, Dx ?
34a
BADRAWY notes MRCP
69. Episcleritis
Not Scleritis. preserved visual acuity
points towards episcleritis + scleritis
associated é ≫ severe eye pain
worse at night & at moving the eye.
34b
BADRAWY notes MRCP
72. Adisonian Crisis é random
BS 3.4 mmol/l ,1st priority
Rx ?
36a
BADRAWY notes MRCP
73. Resuscitation é IV NS +
Hydrocortisone
Given simultaneously é immediate
priority to fluid resuscitation.
Not IV Hydrocortisone alone,not IV
glucose.
36b
BADRAWY notes MRCP
74. AIDS pt on HAART ➜
improved CD4 from 50 to
800 ,c/o reduced vision +
slight eye discomfort, Dx ?
37a
BADRAWY notes MRCP
77. functions as a SERM
no need for PAP smear (no risk of
Cx canecr) / ↓ risk of IHD dt ↓ LDL
cholesterol / much ↓ effect on
estrogen receptor -ve tumors.
38b
BADRAWY notes MRCP
88. A 24 y pt é dusky blue nodular rash
over shin, intermittent diarrhea ±
blood,proctoscopy ➜ moderate
rectal inflammation + normo normo
anemia + ↑ CRP , Dx ?
44a
BADRAWY notes MRCP
89. Ulcerative Colitis
a better choice than Crohn's disease
as predominant lower GI Sx é
proctitis are > suggestive of
ulcerative colitis.
44b
BADRAWY notes MRCP
90. A 45 y pt contact tracing program
referral dt sitting beside a man later
found to be +ve in a flight to
pakistan,no Hx of TB, no BCG
vaccine, normal examination, next
step ?
45a
BADRAWY notes MRCP
91. Mantoux test
a very useful initial screening tool.
Not Chest X-ray (next step after
mantoux), Not prophylactic Anti-TB
Rx.
45b
BADRAWY notes MRCP
92. A 48 y pt blurring Lt eye, Angioid
streaks,macular edema,skin folds é
yellow striations & puckering in the
neck & flexor aspect of joints, Dx ?
46a
BADRAWY notes MRCP
94. A 61 y pt DM, COPD on ↑ dose seretide
inhaler + multiple toe nail fungal
infections, Rx ?
47a
BADRAWY notes MRCP
95. Oral Terbinafine
Topical is ineffective in fungal nail
infection, oral Terbinafine is better
than oral Itraconazole esp. in a COPD
pt é possibility of macrolide Rx for
exacerbation ( ↑ risk of QT
prolongation in this combination).
47b
BADRAWY notes MRCP
96. Acquired lipodystrophy
(young ♀ pt, loss of fat
around the face & upper
body, creatinine 110), which
complement deficiency ?
48a
BADRAWY notes MRCP
98. A 12 y boy é gradually progressive
plaque on his buttock for 3 years
with crusting and induration at the
periphery and scarring at the centre
annular, Dx ?
49a
BADRAWY notes MRCP
99. Lupus vulgaris
Not Tinea corporis
A lesion with central scarring is suggestive
of lupus vulgaris
commonest manifestation of cutaneous
TB, slightly itchy, asymmetrical scaly
Tinea corporis has central clearing and an
advanced scaly raised edge
49b
BADRAWY notes MRCP
100. A pt é cirrhosis secondary to
hepatitis C, progressive
deterioration over 6 months, Hx of
IV heroin abuse & alcoholism,
weight loss and worsening ascites, ↑
alpha-fetoprotein,Dx ?
5 a
BADRAWY notes MRCP
101. HCC
definitive Dx by U/S folloed
by CT guided biopsy, Rx usu
palliative.
5 b
BADRAWY notes MRCP
102. a young ♀ é Sx of pulmonary
HTN (Exertional dyspnea,LL
oedema),best Ix to exclude
2ndry pulmonary HTN ?
51a
BADRAWY notes MRCP
104. clinical phase-ll study in oncology,
testing a new chemotherapy in
patients with a malignant tumour
Which statistical test is most
appropriate to compare the survival
times?
52a
BADRAWY notes MRCP
106. a young pt é aplastic anemia
(BM biopsy ↓ hematopoeitic
cells, fatty BM), most
effective long term Rx ?
53a
BADRAWY notes MRCP
107. Hematopoeitic stem cell
transplantation
a better choice than chemotherapy
Children & young adults ➜ BM
transplantation is 1st choice Rx of
severe aplastic anemia.
53b
BADRAWY notes MRCP
110. an old pt not DM é Lt lateral
hip pain, ↑ é abduction
against resistance, Dx ?
55a
BADRAWY notes MRCP
111. Trochanteric bursitis
Not Osteoarthritis ( limitation with
the full range of movement + deeper
pain within the joint) / not iliopsoas
bursitis (medial pain over femoral
triangle).
55b
BADRAWY notes MRCP
112. a elderly DM pt é Hx of extensive
psoriasis, hot swollen Lt knee joint,
limited mobility, ↑ESR, WBCs,
Creatinine, knee x ray ➜
osteoarthritis with large effusion,
next best step ?
56a
BADRAWY notes MRCP
113. Orthopedic referral for aspiration
& washout.
a better choice than IV
Flucloxacilline ➜ Abiotics without
aspiration & washout of the joint
can cause permenant joint damage.
56b
BADRAWY notes MRCP
114. a middle age ♂ with wt loss,
night sweats,mild asthma,
Dyspnea,cough, nosebleed,
↑ESR, ↑Creatinine,cANCA
+ve, Dx ?
57a
BADRAWY notes MRCP
116. a 16 y ♀ é B/L renal cortical
scarring,Hx of recurrent UTIs with
antibiotis in childhood but no UTIs
since 5 y., HTN (180/104),
Creatinine 186 , how to prevent
further kidney damage ?
58a
BADRAWY notes MRCP
117. ACE Inhibitors
a better choice than Surgical re-insertion
of ureters
imaging + Hx of recurrent UTIs in
childhood ➜ Chronic reflux nephropathy.
∵ no recent UTIs ➜ recurrent infections
are over ➜ little benefit of Surgical re-
insertion of ureters.
58b
BADRAWY notes MRCP
118. An elderly pt é Polymyositis (
proximal ms weakness +
shoulder pain + ↑↑ CK) ,
initial Rx of choice ?
59a
BADRAWY notes MRCP
124. trials a new drug for lowering lipid
levels.2 groups, one receiving the
drug and the other placebo. What is
the best statistical test for
comparing mean cholesterols
between the two groups?
62a
BADRAWY notes MRCP
128. An 58 pt Uncontrolled DM1 é 5
units bloot transfusion 2 wks earlier,
you want to do Hb A1c to assess
him,how long to wait to check Hb
A1c ?
64a
BADRAWY notes MRCP
129. 6 months
Not 3 months
Lifespan of RBCs about 4 months & the
transfusion is large amount (5 units)
➜ wait 6 months before measuring
Hb A1c.
64b
BADRAWY notes MRCP
130. An elderly pt é large stroke ( Lt
hemiparesis, homonymous
hemianopia, left sided neglect,
receptive dysphasia, and poor left
sided co-ordination) what is most
likely to hinder further progress in
rehabilitation?
65a
BADRAWY notes MRCP
131. Receptive dysphasia
dt difficulties complying with
rehabilitation Rx
recovery from neglect is excellent +
function of the affected limb usu improve.
homonymous hemianopia will affect
driving but no effect on daily living.
65b
BADRAWY notes MRCP
132. a pt é Porphyria Cutanea tarda
(hyperpigmentation ,hypertrichosis,
blistering scarring eruptions in
dorsum of hand,worsen in summer,
alcoholic & smoker,urine & stool +ve
for porphyrins),most successful to ↓
severity ?
66a
BADRAWY notes MRCP
136. a 43 y pt é frequent
Headaches worse in the
morning,HTN ,K 3.1,Normal
BMI, Creatinine 112, Test will
get the Dx ?
68a
BADRAWY notes MRCP
137. Renin Aldosterone ratio
Not Urinary metanephrines , Not 24
urinary free cortisol
Hypokalemia + HTN + Normal BMI
+ no Cushing's features ➜ Conn's
syndrome.
68b
BADRAWY notes MRCP
138. a 30 y pt é jaundice, anemia
& splenomegaly,
reticulocytosis + osmotic
fragility, Dx ?
69a
BADRAWY notes MRCP
150. a 17 y ♀ é Collapse after
strenuous exercise,felt weak
and faint afterwards, father
died suddenly at a young age
,normal examination, Dx ?
75a
BADRAWY notes MRCP
151. Cardiac syncope
Not Seizures
MCC is HOCM but lack of physical
signs is against that.
Long QT syndrome & Brugada
syndrome are possibilities
75b
BADRAWY notes MRCP
152. Which is most consistent
with a diagnosis of Bell's
palsy?
76a
BADRAWY notes MRCP
153. Hyperacusis
Not Loss of sensation
loss of lacrimation in lesions before
the geniculate ganglion.
Loss of taste to the anterior 2/3 of
the tongue in severe cases.
76b
BADRAWY notes MRCP
154. a pt é Headache + 3rd nerve
palsy ,Dx ?
77a
BADRAWY notes MRCP
172. the strongest pointer towards
a diagnosis of Type 1
diabetes?
86a
BADRAWY notes MRCP
173. Ketonuria
Not Anti-GAD antibodies
Single autoantibody +ve is not indicative
of a diagnosis of DM1
2 or 3 antibody positivity being a much
stronger pointer towards significant
autoimmune beta cell destruction
86b
BADRAWY notes MRCP
174. VF in a controlled
enviroment (CCU), Rx of
choice ?
87a
BADRAWY notes MRCP
179. 2b3a inhibitor
Platelet function returns to baseline
within eight hours after
discontinuation.
contraindicated in hepatic
dysfunction
89b
BADRAWY notes MRCP
181. The wheal size resulting from the skin
prick test is an excellent predictor of a
positive food challenge to peanuts
The severity of the next allergic reaction
cannot be predicted by skin prick test or
specific lgE,depends on other factors
(amount consumed and intercurrent viral
infections).
9 b
BADRAWY notes MRCP
183. Nystagmus
a better choice than coma
Nystagmus is the commonest
eye sign in wernicke's
91b
BADRAWY notes MRCP
184. Pain in Rt Knee ,Sx of
Reactive Arthritis,Rt Knee
aspirate showed no
organisms, Rx ?
92a
BADRAWY notes MRCP
185. Intra-articular CST injection
a better choice than Diclofenac or
Doxycycline
Systemic NSAIDS are the mainstay of
Rx but in MONOARTHRITIS ➜
Intra-articular CST after ensuring -ve
aspirate from the joint is better.
92b
BADRAWY notes MRCP
192. A 34-y ♀ non-smoker moderate
hypoxaemia,Lung function tests
normal lung volumes but a reduced
Tlco at 45%
PCO2 of 7.9 kPa ?
96a
BADRAWY notes MRCP
193. Pulmonary arteriovenous
malformation
right-to-left shunts, so reducing Tlco
values and provoking
hypoxaemia.Emphysema can cause ↓Tlco
but is usually associated with ↑residual
volume and would be unusual in a young
non-smoker.
96b
BADRAWY notes MRCP
194. A 72-y ♀ left total hip
replacement ,Routine Ix
(WBC 22.5, Lymphocytes 19)
most appropriate Rx ?
97a
BADRAWY notes MRCP
195. Go ahead with the surgery
but keep her under
haematology follow-up
Mostly CLL & doesn't require
Rx now
97b
BADRAWY notes MRCP
196. Lyme disease (tick bite 3
months ago + rash) with
sudden collapse,cause ?
98a
BADRAWY notes MRCP
200. A 16-y ♂ abdominal pain and
vomiting , ↓Power distally
ankle and knee reOexes
absent,sister has similar condition
+basophilic stippling +Urinary D-
ALA +ve, Dx ?
1 a
BADRAWY notes MRCP
201. Lead poisoning
Not Acute intermittent
porphyria (dt basophilic
stippling isn't in AIP)
1 b
BADRAWY notes MRCP