A short overview of the mitochondria aka "POWER HOUSE OF THE CELL" the topic is the part o the cell biology, cellular and molecular pharmacology.

1. TEERTHANKAR MAHAVEER COLLEGE OF PHARMACY
TMU, MORADABAD
MITOCHONDRIA
A
PRESENTATION
COURSE CODE :- MPL106
FOR PARTIAL
FULLFILMENT OF
MASTER OF PHARMACY
(PHARMACOLOGY)
PRESENTED BY:-
MOHIT PANDEY
M.PHARM 1 SEM
(PHARMACOLOGY)
PRESENTED TO:-
DR. MAYUR PORWAL
PROFESSOR
PHARMACOLOGY

2. MITOCHONDRIA
EUKARYOTIC CELL

3. INTRODUCTION
• Double membrane bound organelle.
• known as the “ POWER HOUSE OF THE CELL’’.
• Mitochondria contain their own genetic system.
• Mitochondrial genomes are usually circular DNA molecules like those of
bacteria.
• They lived within larger cells (endo-symbiosis).

4. HISTORY OF MITOCHONDRIA
Discovered by -
Albert von
Kölliker (1857)
Term mitochondria
coined by - Carl
Benda (1898)
The "powerhouse of
the cell", a phrase
coined by Philip
Siekevitz (1957).

5. MITOCHONDRIA

6. PARTS OF MITOCHONDRIA
INNER
MEMBRANE
SPACE
MATRIX
OUTER
MEMBRANE

7. INNER MEMBRANE
• Inner membrane forms several infoldings, known as cristae.
• The number of cristae is three times greater in the mitochondrion of a
cardiac muscle cell than in the mitochondrion of a liver cell.
• Site of ATP production(ETS).
• It contains ATP SYNTHASE which generates ATP in the matrix

8. SPACE MATRIX
• Space matrix contains many mitochondrial enzymes.
• Site for cellular aerobic respiration.
• Oxidation of pyruvate molecule.
• Site for kerb's cycle/TCA cycle.
• Contains circular DNA & ribosomes.

9. OUTER MEMBRANE
• Made up of lipid.
• Contains porins,, which allow movement of ions into and out of the
mitochondrion.
• Act as a selective membrane.
• Enzymes involved in the elongation of fatty acids and the oxidation of
adrenaline can also be found on the outer membrane.

10. FUNCTION OF MITOCHONDRIA
• Generate ATP through reactions of aerobic cellular respiration.
• Site for Krebs cycle and ETS.
• Role in APOPTOSIS ( PROGRAMMED CELL DEATH ).

11. REFERENCES
1) Cooper M Geoffrey ‘’The Cell, A Molecular Approach’’, eighth
edition.
2) Alberts - Molecular Biology of the Cell.
3) Derrickson-Bryan-H._-Tortora-Gerard-J.“Principles-of-anatomy-and-
physiology’’-

12. THANK
YOU