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Myasthenia Gravis - Pathophysiology, Cl. Features, DD

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Stanley Medical College, Department of Medicine
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PATHOPHYSIOLOGY CLINICAL FEATURES AND DIFFERENTIAL DIAGNOSES Myasthenia gravis Dr JISHANTH M Prof Dr A Gowrishankar’s Unit Dept. of Internal Medicine
INTRODUCTION ,[object Object],[object Object],[object Object]
THE NEUROMUSCULAR JUNCTION
PATHOPHYSIOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Myasthenia Gravis ,[object Object],Antibodies Simplified Motor Endplates
PATHOLOGY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THYMIC AND OTHER ASSOCIATED DISORDERS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathologic Features of the Thymus ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
CLINICAL FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object]
CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
OSSERMAN Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PROGRESSION OF DISEASE ,[object Object],[object Object],[object Object],[object Object]
REMISSIONS ,[object Object],[object Object],[object Object],[object Object]
BASIC PHYSICAL EXAMINATION ,[object Object],[object Object],[object Object]
CLINICAL PRESENTATION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bulbar Muscles
1. OCULAR MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2. FACIAL MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object]
3. BULBAR MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
4. LIMB MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],Upper Extremities Deltoids Wrist extensors Finger extensors Triceps > Biceps Lower Extremities Hip flexors (most common) Quadriceps Hamstrings Foot dorsiflexors Plantar flexors
5. RESPIRATORY MUSCLE WEAKNESS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CO-EXISTING AUTOIMMUNE DISEASES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MYASTHENIC CRISIS ,[object Object],[object Object],[object Object],[object Object],[object Object]
NEUROLOGIC CONDITIONS MIMICKING MYASTHENIA GRAVIS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LAMBERT-EATON SYNDROME ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
DRUGS PRECIPITATING MYASTHENIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
Prognosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Differential diagnoses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Myasthenia Gravis - Pathophysiology, Cl. Features, DD

Notes de l'éditeur

  1. Onset from mild to maximal weakness is less than 36 months in 83% of patients