More Related Content Similar to T herapy of hypertension1 Similar to T herapy of hypertension1 (20) More from MD Specialclass More from MD Specialclass (20) 6. Normal Regulation of Blood Pressure ABP = cardiac output x peripheral vascular resistance Regulating the volume of intravascular fluid Baroreflexes, act in combination with RAAS Local release of vasoactive substances from vascular endothelium 24. Sympatholytic Agents – β - Adrenergic Receptor Antagonists BETA – ADRENOCEPTOR BLOCKING DRUGS Nonselective Selective With alpha-blocking ability Nadolol Propranolol Timolol Sotalol Tetralol Pindolol Penbutolol Carteolol Alprenolol Dilevatol Oxyprenolol Atenolol Esmolol Metoprolol Bevantolol Bisoprolol Betaxolol Acebutolol (Practolol) Celiprolol Labetalol Bucindolol Carvedilol 59. Angiotensin-Converting Enzyme Inhibitors 3-7 hours perindoprilat 75% / 35% * perindoprilat Perindopril 1.5 hours 13% Moexiprilat Moexipril 1 hour / 3 hours Ramiprilat Pamipril 2 hours / 25 hours 1hour / 2 hours Quinaprilat Quinapril 4-10 hours trandolaprilat 10% / 70% Trandolaprilat Trandolapril 11.5 hours Fosinoprilat 3 hours Fosinoprilat Fosinoprilat Glucoronide conjugate Fosinopril 10-11 hours benazeprilat 0.5-1 hr / 1-2 hours 35% Benazeprilat Glucuronide conjugates Benazepril 12 hours 7 hours 25% * Lisinopril-lysine analog of enalaprilat 1.3 hrs / 11 hrs 1 hrs / 3-4hrs 60% * Enalaprilat Enalapril 2 hours 1 hour 75% Disulfide dimers & cysteine disulfide Captopril Half-life Peak Plasma Concentration Bioavailability Metabolites Drugs 65. AT 1 Angiotensin II Receptor Antagonists liver 9 hours 2-4 hoours Valsartan Biliary 24 hours 0.5-1 hour Telmisartan Renal & biliary Olmesartan Between 10 & 15 hours 1.4-2.8 hours Olmesartan medoxomil Renal & hepatic EXP 3174 2.5 & 9 hours 1-3 hours Losartan Renal & biliary Glucuronide conjugate 11-15 hours 1.5-2 hours Irbisartan Renal & biliary Glucuronide conjugate 5-9 hours 1-2 hours Eprosartan Renal & biliary Candesartan 9 hours 3-4 hours Candesartan Cilexetil Elimination Metabolite Plasma Half-life Peak Plasma Concentration Drugs 86. Calcium Channel Blocking Drugs Hypotension, cardiac depression, edema 75-150ug/kg IV 80-160mg q 8 hrs angina, HTN, arrhythmia, migraine, CMP Verapamil Dizziness, flushing, nausea 75-150ug/kg IV 30-80mg q 6 hrs Angina, HTN Diltiazem Arrhythmia, nausea, dizziness 200-400mg od angina Misc. Bepridil Same as nifedipine 20mg od/bid angina Niterndipine Same as nifedipine 20-40mg q 8 h HTN Nisoldipine Headache, LBM 60mg q 4 hrs SAH, migraine Nimodipine Hypotension, dizziness, flushing, edema, nausea, Constipation, 20-40mg q 8 hrs Angina, HTN, migraine, CMP, Raynaud’s phenomenon Nifedipine Peripheral edema, HA, dizziness 20-40mg Angina, HTN, CHF Nicardipine HA, fatigue 2.5-10mg HTN Isradipine HA, dizziness 5-10mg HTN, CHF Felodipine HA, peripheral edema 5-10mg Angina, HTN Amlodipine Dihydropyridine group Toxicity Dose Indication Drugs
