Systems Engineering and Software Engineering develop side-by-side for several decades, starting from a need for coping with increasing complexity of physical engineering and computation, both struggling separately to become accepted disciplines. Strangely, there is little collaboration. In reality, software-system problem is similar to the body-mind problem. As a mind cannot exist without a body, software cannot exist without a system it embedded in. Software is a Ghost in the Machine. Increasing complexity blurs boundaries between engineering, computation and management and fuses them into unified Integrative Engineering. Practically, we have single engineering, looking for technological solutions for human problems. The Academy keeps exact sciences worlds apart from human and social studies. The applied disciplines of engineering and management follow the lead of the theoretical studies. In practice, mediating professions of systems engineers, business analysts, IT implementers and systems integrators emerged to bridge the gap. Mediator business is intrinsically risky, and their practice is in dire need for scientific support. This emerging socio-technical science must realize that engineered artifacts are not the same as perceived artifacts. As a map is not the territory it describes, the technology as engineered is not the tool as used. The engineered artifacts actually disappear when used - engineers make technology, people use tools, and the mediators much guide the transformation of the technology in the lab to the tools in the field. Design is never complex, people and nature make technology complex. The mediators must manage and limit the complexity emerging from human-nature-technology interactions. How should we proceed? By understanding that systems are wholes - there is no Mind-Body-Hardware-Software problem. By teaching one unified Engineering - multiple technologies do not multiple "engineerings" make.By focusing on both development and use of technology. By developing "mediation science" and "integrative engineering", starting with exploring how people "put system to use".