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RESPIRATORY DISEASE
Chronic obstructive pulmonary disease. 
COPD is the disease of respiratory tract that produce 
an obstruction to airflow & ultimately can effect both 
the mechanical function of the lung & gas exchange 
capability of the lung. 
It is a preventable & treatable disease. 
Two distinct processes are involved 
- Emphysema 
-Chronic bronchitis 
Usually progressive & is associated with inflammation 
of the lungs as they respond to noxious particles or 
gases.
20% of adult males have COPD 
15% of COPD patients are severely 
symptomatic 
4 th leading cause of death (USA) 
Mortality rate still rising 
prevalence in low birth weight and low 
socioeconomic status 
Tuberculosis in smokers predisposes to 
COPD
Chronic bronchitis 
Chronic inflammation and excess mucus 
production 
Presence of chronic productive cough 
Emphysema 
Damage to the small, sac-like units of the 
lung that deliver oxygen into the lung and 
remove the carbon dioxide 
Chronic cough
Chronic Bronchitis 
Chronic cough 
Shortness of breath 
Increased mucus 
Frequent clearing of throat 
Emphysema 
Chronic cough 
Shortness of breath 
Limited activity level
Long-term smoking is responsible for 80-90 % 
of cases 
○ Smoker, compared to non-smoker, is 10 times 
more likely to die of COPD 
Second-hand smoke, 
Industrial smoke, 
Chemical gases, vapors, mists & fumes 
Dusts from grains, minerals & other materials 
-Alpha-1 antitrypsin(AAT) deficiency
RISK FACTOR FOR COPD 
History of childhood respiratory infections 
Genetic makeup 
Increasing age
Anticholinergics 
Ipratropium(Ipramid- 
Beximco) 
Tiiotropium ( Norvent-sq.) 
Oral & IV antibiotics 
Cephalosporin 
Antipsedomonal penicillin 
Aminoglycoside 
Fluoroquinolones 
Bronchodilators 
Short-acting b2-agonist – 
Salbutamol(Sultolin-sq.) 
Long-acting b2-agonist - 
Salmeterol (Bexitrol- 
Beximco)and 
Formoterol(Symbion-Beximco) 
Methylxanthines – 
Theophylline(Asmanyl-sq.) 
Steroids 
Oral – Prednisolone 
Inhaled – 
Fluticasone(Perinase- 
Beximco), 
Budesonide(Aeronoid- 
Beximco)
THANK YOU

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COPD

  • 2. Chronic obstructive pulmonary disease. COPD is the disease of respiratory tract that produce an obstruction to airflow & ultimately can effect both the mechanical function of the lung & gas exchange capability of the lung. It is a preventable & treatable disease. Two distinct processes are involved - Emphysema -Chronic bronchitis Usually progressive & is associated with inflammation of the lungs as they respond to noxious particles or gases.
  • 3. 20% of adult males have COPD 15% of COPD patients are severely symptomatic 4 th leading cause of death (USA) Mortality rate still rising prevalence in low birth weight and low socioeconomic status Tuberculosis in smokers predisposes to COPD
  • 4.
  • 5. Chronic bronchitis Chronic inflammation and excess mucus production Presence of chronic productive cough Emphysema Damage to the small, sac-like units of the lung that deliver oxygen into the lung and remove the carbon dioxide Chronic cough
  • 6. Chronic Bronchitis Chronic cough Shortness of breath Increased mucus Frequent clearing of throat Emphysema Chronic cough Shortness of breath Limited activity level
  • 7. Long-term smoking is responsible for 80-90 % of cases ○ Smoker, compared to non-smoker, is 10 times more likely to die of COPD Second-hand smoke, Industrial smoke, Chemical gases, vapors, mists & fumes Dusts from grains, minerals & other materials -Alpha-1 antitrypsin(AAT) deficiency
  • 8. RISK FACTOR FOR COPD History of childhood respiratory infections Genetic makeup Increasing age
  • 9.
  • 10. Anticholinergics Ipratropium(Ipramid- Beximco) Tiiotropium ( Norvent-sq.) Oral & IV antibiotics Cephalosporin Antipsedomonal penicillin Aminoglycoside Fluoroquinolones Bronchodilators Short-acting b2-agonist – Salbutamol(Sultolin-sq.) Long-acting b2-agonist - Salmeterol (Bexitrol- Beximco)and Formoterol(Symbion-Beximco) Methylxanthines – Theophylline(Asmanyl-sq.) Steroids Oral – Prednisolone Inhaled – Fluticasone(Perinase- Beximco), Budesonide(Aeronoid- Beximco)
  • 11.