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敏雄 福岡
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Pharmacokinetics icu setting_2007_nagoya
1.
/
/
2.
/
/
3.
3
4.
4
5.
5
6.
6
7.
7
8.
8
9.
9 L
10.
10
L 100mg 2μg/ml(=2mg/L) 100(mg)/2(mg/L)=50L 1kg 1L
11.
11
12.
12 (L)=
(mg)/ (mg/L) Vd (L/kg) 0.3 0.5-1 >1
13.
13
14.
14
15.
15
16.
16
1-1.5mg/kg 17mg/kg
17.
17
1.5mg/kg × 10 50kg Vd ×Vd 50kg×1.1L/kg L kg×1.5mg/kg× mg mg / L mg/L =μg/ml
18.
18
1.5mg/kg × 50kg Vd Vd=1.1L/kg ×Vd 50kg×1.1L/kg 55 L kg×1.5mg/kg× 150 mg 150 mg / 55 L 2.7 mg/L =μg/ml 2-5μg/ml
19.
19
17mg/kg 3.6 30 50kg Vd ×Vd 50kg×1.9L/kg L kg×17mg/kg mg mg / L mg/L =μg/ml
20.
20
17mg/kg 50kg Vd Vd=1.9L/kg ×Vd 50kg×1.9L/kg 95 L kg×17mg/kg 850 mg 850 mg / 95 L 8.95 mg/L =μg/ml 4-10μg/ml
21.
21
50kg 250mg 50kg Vd ×Vd 50kg×0.5L/kg L 250mg mg / L mg/L =μg/ml →
22.
22
50kg 250mg 50kg Vd Vd=0.5L/kg ×Vd 50kg×0.5L/kg 25 L 250mg 250 mg / 25 L 10 mg/L =μg/ml 5-15μg/ml >20μg/ml → 10μg/ml 20μg/ml
23.
23
1-1.5mg/kg 17mg/kg
24.
24
25.
25
26.
26
(CCB) loading dose
27.
27
28.
28 4
5
29.
29 4
5 95%
30.
30
31.
31 H2 blocker
iatrogenic
32.
32
4 iatrogenic