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H1N1                                                                       HIV




     MRSA                                                                       Bacillus anthracis




http://www.hsph.harvard.edu/academics/public-health-practice/; http://commons.wikimedia.org/wiki/File:HIV-1_Transmission_electron_micrograph_AIDS02bbb_lores.jpg; http://registrarism.files.wordpress.com/2009/07/swine-
flu.jpg; http://www.mrsablog.com/uploads/image/MRSa.jpg; http://uk.reuters.com/article/idUKTRE6203MF20100301; http://www.stoptherobbery.com/HealthGuide.html;
http://en.wikipedia.org/wiki/Penicillin; http://aps.unmc.edu/AP/main.php;
http://biosingularity.wordpress.com/2008/08/31/antibody-engineering-cuts-the-collateral-damage-of-cancer-drugs/
vs.




Mammen et al., 1998
http://www.nwfsc.noaa.gov/hab/habs_toxins/marine_biotoxins/detection/elisa.html; http://www.antibodyresearch.com/; http://bookbuilder.cast.org/view_print.php?book=28086
Polyvalent Therapeutics
Linker
Core




 Peptides
http://news.bbc.co.uk/2/hi/health/8021958.stm; http://www.youtube.com/watch?v=KMT1FLzEn9I
http://travel.nationalgeographic.com/places/gallery/china_great-wall-jinshanling.html
β-Defensin                                                                                Magainin-2                                                       Protegrin-1




                                                                Penicillin                                                                                                 Methicillin

Wang et al., Nucleic Acids Research 32, Database Issue D590-D592, 2004; Ganze et al. Nature Reviews Immunology 3, 710-720, 2003; Yang et al. Biochemistry, 42, 4669, 2003; wikipedia
Bacterial Cell



                                                                                                                          Pi




                                                                                                                        Cell Lysis




Nature Reviews Microbiology 3 238-250 (March 2005); www.istockphoto.com; http://cbsuapps.tc.cornell.edu/index.aspx
Fischbach et al.,                   S. aureus           S. simulans   Lysostaphin
                Science, 2009




                                                       Peptidoglycan
                                                       layer
                                       Cytoplasm
                                                       Cytoplasmic
                                                       membrane




www.toons4biz.com; www.clipartof.com
Pi

                    Pi




Effective Coatings against MRSA Strains
Iron Man, 2008; www.turbosquid.com
www.turbosquid.com
Why not change the world?

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